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Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

Nature cell biology, 2014-09, Vol.16 (9), p.876-888

2014

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Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

Science advances, 2019-01, Vol.5 (1), p.eaau3333-eaau3333

2019

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Alzheimer's Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains

Journal of Alzheimer's disease, 2020-01, Vol.75 (4), p.1361-1376

2020

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Increased levels of phospho‐tau217 in neuron cultures and CVN mice infected with Porphyromonas gingivalis

Alzheimer's & dementia, 2021-12, Vol.17, p.e052438-n/a

2021

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Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model

Biochimie, 2010-11, Vol.92 (11), p.1618-1624

2010

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Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice

Mediators of inflammation, 2021, Vol.2021, p.6682657-10

2021

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Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine‐gingipain inhibitor COR388

Pharmacology research & perspectives, 2020-02, Vol.8 (1), p.e00562-n/a

2020

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The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)

Oncogene, 2002-10, Vol.21 (46), p.7067-7076

2002

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Extracellular domain dependence of PTPα transforming activity

Genes to cells : devoted to molecular & cellular mechanisms, 2010-06, Vol.15 (7), p.711-724

2010

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The Minimal Essential Core of a Cysteine-based Protein-tyrosine Phosphatase Revealed by a Novel 16-kDa VH1-like Phosphatase, VHZ

The Journal of biological chemistry, 2004-08, Vol.279 (34), p.35768-35774

2004

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VHY, a Novel Myristoylated Testis-restricted Dual Specificity Protein Phosphatase Related to VHX

The Journal of biological chemistry, 2004-07, Vol.279 (31), p.32586-32591

2004

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Phase 2 Study Design and New Data from the Phase 1 SAD/MAD Trial of LHP588, A Second‐Generation Gingipain Inhibitor for the Treatment of P. Gingivalis ‐ Positive Alzheimer Dementia

Alzheimer's & dementia, 2023-12, Vol.19 (S24), p.n/a

2023

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Signal Transduction in T Lymphocytes Using a Conditional Allele of Sos

Proceedings of the National Academy of Sciences - PNAS, 1995-10, Vol.92 (21), p.9810-9814

1995

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Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome

American journal of respiratory and critical care medicine, 2022-04, Vol.205 (7), p.769-782

2022

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COR388 for the Treatment of Alzheimer’s Disease (4098)

Neurology, 2020-04, Vol.94 (15_supplement)

2020

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Targeting of cathepsin S reduces cystic fibrosis-like lung disease

The European respiratory journal, 2019-03, Vol.53 (3), p.1801523

2019

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COR388, a novel gingipain inhibitor, decreases fragmentation of APOE in the central nervous system of Alzheimer’s disease patients: Human/Human trials: Other

Alzheimer's & dementia, 2020-12, Vol.16 (S9)

2020

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COR388, a novel gingipain inhibitor, decreases fragmentation of APOE in the central nervous system of Alzheimer’s disease patients

Alzheimer's & dementia, 2020-12, Vol.16, p.n/a

2020

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Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70

The EMBO journal, 1997-09, Vol.16 (18), p.5618-5628

1997

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Abstract PO3-26-04: Discovery of novel inhibitors of the epigenetic regulatory KAT6A histone acetyl transferase and their anti-tumor activity in breast cancer cells

Cancer research (Chicago, Ill.), 2024-05, Vol.84 (9_Supplement), p.PO3-26-04-PO3-26-04

2024

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Abstract 3217: Discovery of novel inhibitors of the epigenetic regulator Kat6a histone acetyl transferase and characterization of their anti-tumor activity

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.3217-3217

2024

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Targeting porphyromonas gingivalis to treat Alzheimer’s disease and comorbid cardiovascular disease: Developing topics

Alzheimer's & dementia, 2020-12, Vol.16 (S9)

2020

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Targeting porphyromonas gingivalis to treat Alzheimer’s disease and comorbid cardiovascular disease

Alzheimer's & dementia, 2020-12, Vol.16, p.n/a

2020

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Comprehensive Alzheimer’s pathology is induced by P. gingivalis infection: COR388 and other gingipain inhibitors protect against synaptic loss

Alzheimer's & dementia, 2020-12, Vol.16, p.n/a

2020

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Comprehensive Alzheimer’s pathology is induced by P. gingivalis infection: COR388 and other gingipain inhibitors protect against synaptic loss: Molecular and cell biology/synaptic disruption

Alzheimer's & dementia, 2020-12, Vol.16 (S3)

2020

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Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

Alzheimer's Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains

Increased levels of phospho‐tau217 in neuron cultures and CVN mice infected with Porphyromonas gingivalis

Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model

Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice

Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine‐gingipain inhibitor COR388

The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)

Extracellular domain dependence of PTPα transforming activity

The Minimal Essential Core of a Cysteine-based Protein-tyrosine Phosphatase Revealed by a Novel 16-kDa VH1-like Phosphatase, VHZ

VHY, a Novel Myristoylated Testis-restricted Dual Specificity Protein Phosphatase Related to VHX

Phase 2 Study Design and New Data from the Phase 1 SAD/MAD Trial of LHP588, A Second‐Generation Gingipain Inhibitor for the Treatment of P. Gingivalis ‐ Positive Alzheimer Dementia

Signal Transduction in T Lymphocytes Using a Conditional Allele of Sos

Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome

COR388 for the Treatment of Alzheimer’s Disease (4098)

Targeting of cathepsin S reduces cystic fibrosis-like lung disease

COR388, a novel gingipain inhibitor, decreases fragmentation of APOE in the central nervous system of Alzheimer’s disease patients: Human/Human trials: Other

COR388, a novel gingipain inhibitor, decreases fragmentation of APOE in the central nervous system of Alzheimer’s disease patients

Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70

Abstract PO3-26-04: Discovery of novel inhibitors of the epigenetic regulatory KAT6A histone acetyl transferase and their anti-tumor activity in breast cancer cells

Abstract 3217: Discovery of novel inhibitors of the epigenetic regulator Kat6a histone acetyl transferase and characterization of their anti-tumor activity

Targeting porphyromonas gingivalis to treat Alzheimer’s disease and comorbid cardiovascular disease: Developing topics

Targeting porphyromonas gingivalis to treat Alzheimer’s disease and comorbid cardiovascular disease

Comprehensive Alzheimer’s pathology is induced by P. gingivalis infection: COR388 and other gingipain inhibitors protect against synaptic loss

Comprehensive Alzheimer’s pathology is induced by P. gingivalis infection: COR388 and other gingipain inhibitors protect against synaptic loss: Molecular and cell biology/synaptic disruption

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