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Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical

PloS one, 2016-09, Vol.11 (9), p.e0163821

2016

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Synthesis and Chemical and Biological Comparison of Nitroxyl- and Nitric Oxide-Releasing Diazeniumdiolate-Based Aspirin Derivatives

Journal of medicinal chemistry, 2013-10, Vol.56 (20), p.7804-7820

2013

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Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs

Bioorganic & medicinal chemistry, 2012-05, Vol.20 (9), p.3094-3099

2012

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Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance

Redox biology, 2013-01, Vol.1 (1), p.115-124

2013

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O2‑Functionalized Methylamine Diazeniumdiolates: Evidence for E ⇄ Z Equilibration in an Acyclic System

Journal of organic chemistry, 2012-12, Vol.77 (23), p.10804-10810

2012

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The nitric oxide prodrug JS-K is effective against non-small-cell lung cancer cells in vitro and in vivo: involvement of reactive oxygen species

The Journal of pharmacology and experimental therapeutics, 2011-02, Vol.336 (2), p.313-320

2011

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Hepatoselective Nitric Oxide (NO) Donors, V-PYRRO/NO and V-PROLI/NO, in Nonalcoholic Fatty Liver Disease: A Comparison of Antisteatotic Effects with the Biotransformation and Pharmacokinetics

Drug metabolism and disposition, 2015-07, Vol.43 (7), p.1028-1036

2015

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The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet

Biochemical pharmacology, 2015-02, Vol.93 (3), p.389-400

2015

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Nitric Oxide (NO) Releasing Poly ADP-ribose Polymerase 1 (PARP-1) Inhibitors Targeted to Glutathione S‑Transferase P1-Overexpressing Cancer Cells

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2292-2302

2014

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Direct Reaction of Amides with Nitric Oxide To Form Diazeniumdiolates

Journal of organic chemistry, 2014-10, Vol.79 (19), p.9389-9393

2014

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PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells

Bioorganic & medicinal chemistry, 2015-08, Vol.23 (15), p.4980-4988

2015

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Decoding Nitric Oxide Release Rates of Amine-Based Diazeniumdiolates

The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory, 2013-08, Vol.117 (30), p.6671-6677

2013

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Enzymatic generation of the NO/HNO-releasing IPA/NO anion at controlled rates in physiological media using β-galactosidase

Nitric oxide, 2013-11, Vol.35, p.131-136

2013

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Aminolysis of an N‑Diazeniumdiolated Amidine as an Approach to Diazeniumdiolated Ammonia

Journal of organic chemistry, 2014-05, Vol.79 (10), p.4512-4516

2014

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Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells

Leukemia research, 2014-03, Vol.38 (3), p.377-382

2014

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“Click” Reaction in Conjunction with Diazeniumdiolate Chemistry: Developing High-Load Nitric Oxide Donors

Organic letters, 2010-10, Vol.12 (19), p.4256-4259

2010

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Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate

PloS one, 2016-09, Vol.11 (9), p.e0163821

2016

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Cancer Cell-Directed Drug Delivery and Chemopotentiating Effects by GSTP1-Activated Nitric Oxide (NO)-Releasing Prodrug

Biophysical journal, 2016-02, Vol.110 (3), p.541a-541a

2016

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O 2 -Functionalized Methylamine Diazeniumdiolates: Evidence for E ⇄ Z Equilibration in an Acyclic System

Journal of organic chemistry, 2012-12, Vol.77 (23), p.10804-10810

2012

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Cross-Linking Protein Glutathionylation Mediated by O 2 -Arylated Bis-Diazeniumdiolate “Double JS-K”

Chemical research in toxicology, 2012-12, Vol.25 (12), p.2670-2677

2012

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Abstract 3334: GSTP1-activated nitric oxide-releasing/PARP inhibitor hybrid prodrugs induce cancer cell death through ROS/RNS, DNA damage, ER stress, and apoptosis

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.3334-3334

2013

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Abstract 2922: Stoichiometric depletion of glutathione by anticancer agent JS-K

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.2922-2922

2013

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Abstract C180: The effect of JS-K, a lead O2-arylated diazeniumdiolate anticancer agent, on the cellular glutathione status

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.C180-C180

2011

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Cross-Linking Protein Glutathionylation Mediated by O2‑Arylated Bis-Diazeniumdiolate “Double JS-K”

Chemical research in toxicology, 2012-12, Vol.25 (12), p.2670-2677

2012

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Cross-Linking Protein Glutathionylation Mediated by O super(2)-Arylated Bis-Diazeniumdiolate "Double JS-K"

Chemical research in toxicology, 2012-12, Vol.25 (12), p.2670-2677-2670-2677

2012

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Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical

Synthesis and Chemical and Biological Comparison of Nitroxyl- and Nitric Oxide-Releasing Diazeniumdiolate-Based Aspirin Derivatives

Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs

Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance

O2‑Functionalized Methylamine Diazeniumdiolates: Evidence for E ⇄ Z Equilibration in an Acyclic System

The nitric oxide prodrug JS-K is effective against non-small-cell lung cancer cells in vitro and in vivo: involvement of reactive oxygen species

Hepatoselective Nitric Oxide (NO) Donors, V-PYRRO/NO and V-PROLI/NO, in Nonalcoholic Fatty Liver Disease: A Comparison of Antisteatotic Effects with the Biotransformation and Pharmacokinetics

The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet

Nitric Oxide (NO) Releasing Poly ADP-ribose Polymerase 1 (PARP-1) Inhibitors Targeted to Glutathione S‑Transferase P1-Overexpressing Cancer Cells

Direct Reaction of Amides with Nitric Oxide To Form Diazeniumdiolates

PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells

Decoding Nitric Oxide Release Rates of Amine-Based Diazeniumdiolates

Enzymatic generation of the NO/HNO-releasing IPA/NO anion at controlled rates in physiological media using β-galactosidase

Aminolysis of an N‑Diazeniumdiolated Amidine as an Approach to Diazeniumdiolated Ammonia

Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells

“Click” Reaction in Conjunction with Diazeniumdiolate Chemistry: Developing High-Load Nitric Oxide Donors

Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate

Cancer Cell-Directed Drug Delivery and Chemopotentiating Effects by GSTP1-Activated Nitric Oxide (NO)-Releasing Prodrug

O 2 -Functionalized Methylamine Diazeniumdiolates: Evidence for E ⇄ Z Equilibration in an Acyclic System

Cross-Linking Protein Glutathionylation Mediated by O 2 -Arylated Bis-Diazeniumdiolate “Double JS-K”

Abstract 3334: GSTP1-activated nitric oxide-releasing/PARP inhibitor hybrid prodrugs induce cancer cell death through ROS/RNS, DNA damage, ER stress, and apoptosis

Abstract 2922: Stoichiometric depletion of glutathione by anticancer agent JS-K

Abstract C180: The effect of JS-K, a lead O2-arylated diazeniumdiolate anticancer agent, on the cellular glutathione status

Cross-Linking Protein Glutathionylation Mediated by O2‑Arylated Bis-Diazeniumdiolate “Double JS-K”

Cross-Linking Protein Glutathionylation Mediated by O super(2)-Arylated Bis-Diazeniumdiolate "Double JS-K"

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