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Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

Genome research, 2014-12, Vol.24 (12), p.1918-1931

2014

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Introduction: thymus development and function in health and disease

Seminars in immunopathology, 2021-02, Vol.43 (1), p.1-3

Holländer, Georg A.

2021

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Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells

The EMBO journal, 2020-01, Vol.39 (1), p.e101828-n/a

2020

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Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells

Nature immunology, 2016-10, Vol.17 (10), p.1206-1215

2016

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Delta-like 4 is indispensable in thymic environment specific for T cell development

The Journal of experimental medicine, 2008-10, Vol.205 (11), p.2507-2513

2008

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The role of thymic tolerance in CNS autoimmune disease

Nature reviews. Neurology, 2018-12, Vol.14 (12), p.723-734

2018

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Comment on "Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells"

The Journal of immunology (1950), 2019-11, Vol.203 (9), p.2355-2355

2019

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Ageing compromises mouse thymus function and remodels epithelial cell differentiation

eLife, 2020-08, Vol.9

2020

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Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells

Nature communications, 2023-07, Vol.14 (1), p.4071-4071, Article 4071

2023

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A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla

Nature immunology, 2014-06, Vol.15 (6), p.554-561

2014

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GLI3 Constrains Digit Number by Controlling Both Progenitor Proliferation and BMP-Dependent Exit to Chondrogenesis

Developmental cell, 2012-04, Vol.22 (4), p.837-848

2012

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RBFOX splicing factors contribute to a broad but selective recapitulation of peripheral tissue splicing patterns in the thymus

Genome research, 2021-11, Vol.31 (11), p.2022-2034

2021

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RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy

Nature (London), 2021-01, Vol.589 (7842), p.442-447

2021

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

Nature, 2006-12, Vol.444 (7120), p.724-729

2006

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Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (24), p.9885-9890

2013

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Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis

The Journal of immunology (1950), 2018-07, Vol.201 (2), p.524-532

2018

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Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging

Blood, 2007-03, Vol.109 (6), p.2529-2537

2007

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Generation of a complete thymic microenvironment by MTS24 + thymic epithelial cells

Nature immunology, 2002-07, Vol.3 (7), p.635-642

2002

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A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice

Blood, 2017-12, Vol.130 (23), p.2504-2515

2017

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Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens

Frontiers in immunology, 2019-01, Vol.9, p.2902-2902

2019

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Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Nature communications, 2021-06, Vol.12 (1), p.3933-19, Article 3933

2021

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Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development

Frontiers in immunology, 2018-09, Vol.9, p.2120-2120

2018

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Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells

Blood, 2007-05, Vol.109 (9), p.3803-3811

2007

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Autoimmune Polyendocrine Syndrome Type 1 and NALP5, a Parathyroid Autoantigen

The New England journal of medicine, 2008-03, Vol.358 (10), p.1018-1028

2008

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In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering

Nature communications, 2017-12, Vol.8 (1), p.2109-17, Article 2109

2017

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Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

Introduction: thymus development and function in health and disease

Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells

Delta-like 4 is indispensable in thymic environment specific for T cell development

The role of thymic tolerance in CNS autoimmune disease

Comment on "Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells"

Ageing compromises mouse thymus function and remodels epithelial cell differentiation

Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla

GLI3 Constrains Digit Number by Controlling Both Progenitor Proliferation and BMP-Dependent Exit to Chondrogenesis

RBFOX splicing factors contribute to a broad but selective recapitulation of peripheral tissue splicing patterns in the thymus

RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells

Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis

Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging

Generation of a complete thymic microenvironment by MTS24 + thymic epithelial cells

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice

Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells

Autoimmune Polyendocrine Syndrome Type 1 and NALP5, a Parathyroid Autoantigen

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering

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