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Oncogenic protein interfaces: small molecules, big challenges

Nature reviews. Cancer, 2014-04, Vol.14 (4), p.248

2014

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Mitochondrial fission – a drug target for cytoprotection or cytodestruction?

Pharmacology research & perspectives, 2016-06, Vol.4 (3), p.e00235-n/a

2016

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Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation

Journal of Virology, 2009-10, Vol.83 (20), p.10366-10373

2009

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Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster

Insect biochemistry and molecular biology, 2021-04, Vol.131, p.103547-103547, Article 103547

2021

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Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission

Cardiovascular research, 2022-01, Vol.118 (1), p.282-294

2022

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A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma

Oncogene, 2021-04, Vol.40 (13), p.2367-2381

2021

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TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members

PloS one, 2012-05, Vol.7 (5), p.e37470-e37470

2012

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Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability

Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (6), p.1

2022

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In Vitro Generation of Neuraminidase Inhibitor Resistance in A(H5N1) Influenza Viruses

Antimicrobial Agents and Chemotherapy, 2009-10, Vol.53 (10), p.4433-4440

2009

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Identification of RNA-Binding Proteins as Targetable Putative Oncogenes in Neuroblastoma

International journal of molecular sciences, 2020-07, Vol.21 (14), p.5098

2020

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Structural Analysis of the Complex of Human Transthyretin with 3′,5′-Dichlorophenylanthranilic Acid at 1.5 Å Resolution

Molecules (Basel, Switzerland), 2022-10, Vol.27 (21), p.7206

2022

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A novel small molecule inhibitor of human Drp1

Scientific reports, 2022-12, Vol.12 (1), p.21531-21531, Article 21531

2022

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A bias of Asparagine to Lysine mutations in SARS-CoV-2 outside the receptor binding domain affects protein flexibility

Frontiers in immunology, 2022-12, Vol.13, p.954435-954435

2022

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Structure of the Lectin Regulatory Domain of the Cholesterol-Dependent Cytolysin Lectinolysin Reveals the Basis for Its Lewis Antigen Specificity

Structure (London), 2012-02, Vol.20 (2), p.248-258

2012

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Oseltamivir Resistance and the H274Y Neuraminidase Mutation in Seasonal, Pandemic and Highly Pathogenic Influenza Viruses

Drugs (New York, N.Y.), 2009-01, Vol.69 (18), p.2523-2531

2009

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Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1)

PloS one, 2015-11, Vol.10 (11), p.e0141252

2015

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A Homodimer Model Can Resolve the Conundrum as to How Cytochrome P450 Oxidoreductase and Cytochrome b5 Compete for the Same Binding Site on Cytochrome P450c17

Current protein & peptide science, 2017-05, Vol.18 (5), p.515

2017

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Inhibitors of the Oncogenic PA2G4-MYCN Protein-Protein Interface

Cancers, 2023-03, Vol.15 (6), p.1822

2023

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Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding

Biochemical journal, 2015-01, Vol.465 (2), p.347-357

2015

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Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407

Frontiers in microbiology, 2017-08, Vol.8, p.1525-1525

2017

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Drug Discovery in Real Life: An Online Learning Activity for Bioinformatics Students

Journal of chemical education, 2023-02, Vol.100 (2), p.1053-1057

2023

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New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

Pharmacology & therapeutics (Oxford), 2020-09, Vol.213, p.107594-107594, Article 107594

2020

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Analysis of physicochemical properties of protein-protein interaction modulators suggests stronger alignment with the "rule of five"

RSC medicinal chemistry, 2021-10, Vol.12 (1), p.1731-1749

2021

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A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development

The Journal of infectious diseases, 2014-10, Vol.210 (8), p.1325-1338

2014

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Oncogenic protein interfaces: small molecules, big challenges

Mitochondrial fission – a drug target for cytoprotection or cytodestruction?

Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation

Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster

Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission

A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma

TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability

In Vitro Generation of Neuraminidase Inhibitor Resistance in A(H5N1) Influenza Viruses

Identification of RNA-Binding Proteins as Targetable Putative Oncogenes in Neuroblastoma

Structural Analysis of the Complex of Human Transthyretin with 3′,5′-Dichlorophenylanthranilic Acid at 1.5 Å Resolution

A novel small molecule inhibitor of human Drp1

A bias of Asparagine to Lysine mutations in SARS-CoV-2 outside the receptor binding domain affects protein flexibility

Structure of the Lectin Regulatory Domain of the Cholesterol-Dependent Cytolysin Lectinolysin Reveals the Basis for Its Lewis Antigen Specificity

Oseltamivir Resistance and the H274Y Neuraminidase Mutation in Seasonal, Pandemic and Highly Pathogenic Influenza Viruses

Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1)

A Homodimer Model Can Resolve the Conundrum as to How Cytochrome P450 Oxidoreductase and Cytochrome b5 Compete for the Same Binding Site on Cytochrome P450c17

Inhibitors of the Oncogenic PA2G4-MYCN Protein-Protein Interface

Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding

Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407

Drug Discovery in Real Life: An Online Learning Activity for Bioinformatics Students

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

Analysis of physicochemical properties of protein-protein interaction modulators suggests stronger alignment with the "rule of five"

A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development

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