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Emerging RUNX2-Mediated Gene Regulatory Mechanisms Consisting of Multi-Layered Regulatory Networks in Skeletal Development

International journal of molecular sciences, 2023-02, Vol.24 (3), p.2979

Hojo, Hironori

2023

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Understanding paraxial mesoderm development and sclerotome specification for skeletal repair

Experimental and Molecular Medicine, 2020, 52(0), , pp.1-12

2020

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Sp7 Action in the Skeleton: Its Mode of Action, Functions, and Relevance to Skeletal Diseases

International journal of molecular sciences, 2022-05, Vol.23 (10), p.5647

2022

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Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

Nature communications, 2021-11, Vol.12 (1), p.6271-6271, Article 6271

2021

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A neomorphic variant in SP7 alters sequence specificity and causes a high-turnover bone disorder

Nature communications, 2022-02, Vol.13 (1), p.700-700, Article 700

2022

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Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte

Cell reports (Cambridge), 2015-07, Vol.12 (2), p.229-243

2015

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Generation of orthotopically functional salivary gland from embryonic stem cells

Nature communications, 2018-10, Vol.9 (1), p.4216-13, Article 4216

2018

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Mesenchymal stromal cells in the bone marrow niche consist of multi-populations with distinct transcriptional and epigenetic properties

Scientific reports, 2021-08, Vol.11 (1), p.15811-15811, Article 15811

2021

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ChIP-Seq Assays from Mammalian Cartilage and Chondrocytes

Methods in molecular biology (Clifton, N.J.), 2021, Vol.2245, p.167

2021

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Practical Compass of Single-Cell RNA-Seq Analysis

Current osteoporosis reports, 2024-10, Vol.22 (5), p.433-440

2024

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Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development

Nature communications, 2022-10, Vol.13 (1), p.6187-6187, Article 6187

2022

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Unraveling the hidden complexity: Exploring dental tissues through single-cell transcriptional profiling

Regenerative therapy, 2024-12, Vol.27, p.218-229

2024

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Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

Arthritis research & therapy, 2019-11, Vol.21 (1), p.247-247, Article 247

2019

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The Progress of Stem Cell Technology for Skeletal Regeneration

International journal of molecular sciences, 2021-01, Vol.22 (3), p.1404

2021

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Runx2 Regulates Galnt3 and Fgf23 Expressions and Galnt3 Decelerates Osteoid Mineralization by Stabilizing Fgf23

International journal of molecular sciences, 2024-02, Vol.25 (4), p.2275

2024

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Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (28), p.11397-11402

2013

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Induction and expansion of human PRRX1 + limb-bud-like mesenchymal cells from pluripotent stem cells

Nature biomedical engineering, 2021-08, Vol.5 (8), p.926-940

2021

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Stem cell-based modeling and single-cell multiomics reveal gene-regulatory mechanisms underlying human skeletal development

Cell reports (Cambridge), 2023-04, Vol.42 (4), p.112276-112276, Article 112276

2023

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Conditional inactivation of the L‐type amino acid transporter LAT1 in chondrocytes models idiopathic scoliosis in mice

Journal of cellular physiology, 2022-11, Vol.237 (11), p.4292-4302

2022

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Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell–cell interactions underlying the bone repair process

Regenerative therapy, 2022-12, Vol.21, p.9-18

2022

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Nrf2 Negatively Regulates Osteoblast Differentiation via Interfering with Runx2-dependent Transcriptional Activation

The Journal of biological chemistry, 2006-06, Vol.281 (26), p.18015-18024

2006

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Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice

PloS one, 2014-10, Vol.9 (10), p.e109597-e109597

2014

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Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds

Stem cell reports, 2019-09, Vol.13 (3), p.530-544

2019

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Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages

Cell reports (Cambridge), 2022-09, Vol.40 (10), p.111315-111315, Article 111315

2022

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Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis

International journal of molecular sciences, 2020-03, Vol.21 (7), p.2425

2020

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Emerging RUNX2-Mediated Gene Regulatory Mechanisms Consisting of Multi-Layered Regulatory Networks in Skeletal Development

Understanding paraxial mesoderm development and sclerotome specification for skeletal repair

Sp7 Action in the Skeleton: Its Mode of Action, Functions, and Relevance to Skeletal Diseases

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

A neomorphic variant in SP7 alters sequence specificity and causes a high-turnover bone disorder

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte

Generation of orthotopically functional salivary gland from embryonic stem cells

Mesenchymal stromal cells in the bone marrow niche consist of multi-populations with distinct transcriptional and epigenetic properties

ChIP-Seq Assays from Mammalian Cartilage and Chondrocytes

Practical Compass of Single-Cell RNA-Seq Analysis

Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development

Unraveling the hidden complexity: Exploring dental tissues through single-cell transcriptional profiling

Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

The Progress of Stem Cell Technology for Skeletal Regeneration

Runx2 Regulates Galnt3 and Fgf23 Expressions and Galnt3 Decelerates Osteoid Mineralization by Stabilizing Fgf23

Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis

Induction and expansion of human PRRX1 + limb-bud-like mesenchymal cells from pluripotent stem cells

Stem cell-based modeling and single-cell multiomics reveal gene-regulatory mechanisms underlying human skeletal development

Conditional inactivation of the L‐type amino acid transporter LAT1 in chondrocytes models idiopathic scoliosis in mice

Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell–cell interactions underlying the bone repair process

Nrf2 Negatively Regulates Osteoblast Differentiation via Interfering with Runx2-dependent Transcriptional Activation

Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice

Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds

Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages

Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis

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