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Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic

Current biology, 2024-09, Vol.34 (18), p.4170-4183.e9

2024

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Structure of a Bag/Hsc70 Complex: Convergent Functional Evolution of Hsp70 Nucleotide Exchange Factors

Science (American Association for the Advancement of Science), 2001-02, Vol.291 (5508), p.1553-1557

2001

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Pathophysiology of protein aggregation and extended phenotyping in filaminopathy

Brain (London, England : 1878), 2012-09, Vol.135 (Pt 9), p.2642-2660

2012

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BAG3-mediated proteostasis at a glance

Journal of cell science, 2017-09, Vol.130 (17), p.2781-2788

2017

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BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes

Autophagy, 2019-07, Vol.15 (7), p.1199-1213

2019

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The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover

Cell, 2017-04, Vol.169 (3), p.470-482.e13

2017

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Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle

Autophagy, 2015-01, Vol.11 (3), p.538-546

2015

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BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP

Molecular biology of the cell, 2005-12, Vol.16 (12), p.5891-5900

2005

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Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy

Nature communications, 2021-06, Vol.12 (1), p.1-17, Article 3575

2021

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Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

Current biology, 2010-01, Vol.20 (2), p.143-148

2010

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Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

Science (American Association for the Advancement of Science), 2010-08, Vol.329 (5993), p.805-810

2010

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The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator

Molecular biology of the cell, 2004-09, Vol.15 (9), p.4003-4010

2004

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The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

Nature cell biology, 2001-01, Vol.3 (1), p.93-96

2001

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The Chaperone-associated Ubiquitin Ligase CHIP Is Able to Target p53 for Proteasomal Degradation

The Journal of biological chemistry, 2005-07, Vol.280 (29), p.27443-27448

2005

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Chaperone-assisted degradation: multiple paths to destruction

Biological chemistry, 2010-05, Vol.391 (5), p.481-489

2010

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ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation

Human mutation, 2010-04, Vol.31 (4), p.466-476

2010

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From the cradle to the grave: molecular chaperones that may choose between folding and degradation

EMBO reports, 2001-10, Vol.2 (10), p.885-890

2001

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The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy

Biochimica et biophysica acta. Molecular cell research, 2019-10, Vol.1866 (10), p.1556-1566

2019

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Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

Current biology, 2001-10, Vol.11 (20), p.1569-1577

2001

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Protein quality control: U-box-containing E3 ubiquitin ligases join the fold

Trends in Biochemical Sciences, 2002-07, Vol.27 (7), p.368-375

2002

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UCHL1 regulates ubiquitination and recycling of the neural cell adhesion molecule NCAM

The FEBS journal, 2012-12, Vol.279 (23), p.4398-4409

2012

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Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis

Journal of the American Society of Nephrology, 2020-03, Vol.31 (3), p.544-559

2020

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The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1

Biochimica et biophysica acta. Molecular cell research, 2017-01, Vol.1864 (1), p.62-75

2017

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HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis

Molecular biology of the cell, 2014-08, Vol.25 (15), p.2260-2271

2014

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Identification of the Mitochondrial MSRB2 as a Binding Partner of LG72

Cellular and molecular neurobiology, 2014-11, Vol.34 (8), p.1123-1130

2014

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Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic

Structure of a Bag/Hsc70 Complex: Convergent Functional Evolution of Hsp70 Nucleotide Exchange Factors

Pathophysiology of protein aggregation and extended phenotyping in filaminopathy

BAG3-mediated proteostasis at a glance

BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes

The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover

Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle

BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP

Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

The Chaperone-associated Ubiquitin Ligase CHIP Is Able to Target p53 for Proteasomal Degradation

Chaperone-assisted degradation: multiple paths to destruction

ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation

From the cradle to the grave: molecular chaperones that may choose between folding and degradation

The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy

Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

Protein quality control: U-box-containing E3 ubiquitin ligases join the fold

UCHL1 regulates ubiquitination and recycling of the neural cell adhesion molecule NCAM

Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis

The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1

HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis

Identification of the Mitochondrial MSRB2 as a Binding Partner of LG72

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