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Targeting the nucleotide metabolism of Trypanosoma brucei and other trypanosomatids

FEMS microbiology reviews, 2023-05, Vol.47 (3), p.1

Hofer, Anders

2023

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Nucleoside-catabolizing Enzymes in Mycoplasma-infected Tumor Cell Cultures Compromise the Cytostatic Activity of the Anticancer Drug Gemcitabine

The Journal of biological chemistry, 2014-05, Vol.289 (19), p.13054-13065

2014

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Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

Nature communications, 2019-12, Vol.10 (1), p.5564-11, Article 5564

2019

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DNA building blocks: keeping control of manufacture

Critical reviews in biochemistry and molecular biology, 2012-01, Vol.47 (1), p.50-63

2012

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Regulation of Mammalian Ribonucleotide Reduction and dNTP Pools after DNA Damage and in Resting Cells

The Journal of biological chemistry, 2006-03, Vol.281 (12), p.7834-7841

2006

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PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction

Molecular microbiology, 2018-08, Vol.109 (3), p.291-305

2018

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Enzymatically Active Mammalian Ribonucleotide Reductase Exists Primarily as an α6β2 Octamer

The Journal of biological chemistry, 2006-09, Vol.281 (38), p.27705-27711

2006

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Phytochemical Analysis and Trypanocidal Activity of Marrubium incanum Desr

Molecules (Basel, Switzerland), 2020-07, Vol.25 (14), p.3140

2020

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Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit

eLife, 2018-02, Vol.7

2018

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Biological Activities of the Essential Oil from Erigeron floribundus

Molecules (Basel, Switzerland), 2016-08, Vol.21 (8), p.1065

2016

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Oligomerization Status Directs Overall Activity Regulation of the Escherichia coli Class Ia Ribonucleotide Reductase

The Journal of biological chemistry, 2008-12, Vol.283 (51), p.35310-35318

2008

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An overlooked horticultural crop, Smyrnium olusatrum , as a potential source of compounds effective against African trypanosomiasis

Parasitology international, 2017-04, Vol.66 (2), p.146-151

2017

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14-3-3 Activated Bacterial Exotoxins AexT and ExoT Share Actin and the SH2 Domains of CRK Proteins as Targets for ADP-Ribosylation

Pathogens (Basel), 2022-12, Vol.11 (12), p.1497

2022

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Expression, Purification, Characterization, and in Vivo Targeting of Trypanosome CTP Synthetase for Treatment of African Sleeping Sickness

The Journal of biological chemistry, 2007-04, Vol.282 (16), p.11858-11865

2007

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Biochemical Characterization of the Split Class II Ribonucleotide Reductase from Pseudomonas aeruginosa

PloS one, 2015-07, Vol.10 (7), p.e0134293-e0134293

2015

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Antitrypanosomal Activity of Anthriscus Nemorosa Essential Oils and Combinations of Their Main Constituents

Antibiotics (Basel), 2021-11, Vol.10 (11), p.1413

2021

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Substrate kinetics and substrate effects on the quaternary structure of barley UDP-glucose pyrophosphorylase

Phytochemistry (Oxford), 2012-07, Vol.79, p.39-45

2012

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Adenosine Kinase Mediates High Affinity Adenosine Salvage in Trypanosoma brucei

The Journal of biological chemistry, 2008-02, Vol.283 (9), p.5380-5388

2008

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Quantification of all 12 canonical ribonucleotides by real-time fluorogenic in vitro transcription

Nucleic acids research, 2024-01, Vol.52 (1), p.e6

2024

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Cryo-EM Reveals Promoter DNA Binding and Conformational Flexibility of the General Transcription Factor TFIID

Structure (London), 2009-11, Vol.17 (11), p.1442-1452

2009

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The Ribonucleotide Reductase R1 Homolog of Murine Cytomegalovirus Is Not a Functional Enzyme Subunit but Is Required for Pathogenesis

Journal of Virology, 2004-04, Vol.78 (8), p.4278-4288

2004

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Trypanosoma brucei CTP Synthetase: A Target for the Treatment of African Sleeping Sickness

Proceedings of the National Academy of Sciences - PNAS, 2001-05, Vol.98 (11), p.6412-6416

2001

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Isocratic HPLC analysis for the simultaneous determination of dNTPs, rNTPs and ADP in biological samples

Nucleic acids research, 2022-02, Vol.50 (3), p.e18

2022

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Mosquito control with green nanopesticides: towards the One Health approach? A review of non-target effects

Environmental science and pollution research international, 2018-04, Vol.25 (11), p.10184-10206

2018

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Metabolic Fate of Oxidized Guanine Ribonucleotides in Mammalian Cells

Biochemistry (Easton), 1999-03, Vol.38 (12), p.3610-3614

1999

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Targeting the nucleotide metabolism of Trypanosoma brucei and other trypanosomatids

Nucleoside-catabolizing Enzymes in Mycoplasma-infected Tumor Cell Cultures Compromise the Cytostatic Activity of the Anticancer Drug Gemcitabine

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

DNA building blocks: keeping control of manufacture

Regulation of Mammalian Ribonucleotide Reduction and dNTP Pools after DNA Damage and in Resting Cells

PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction

Enzymatically Active Mammalian Ribonucleotide Reductase Exists Primarily as an α6β2 Octamer

Phytochemical Analysis and Trypanocidal Activity of Marrubium incanum Desr

Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit

Biological Activities of the Essential Oil from Erigeron floribundus

Oligomerization Status Directs Overall Activity Regulation of the Escherichia coli Class Ia Ribonucleotide Reductase

An overlooked horticultural crop, Smyrnium olusatrum , as a potential source of compounds effective against African trypanosomiasis

14-3-3 Activated Bacterial Exotoxins AexT and ExoT Share Actin and the SH2 Domains of CRK Proteins as Targets for ADP-Ribosylation

Expression, Purification, Characterization, and in Vivo Targeting of Trypanosome CTP Synthetase for Treatment of African Sleeping Sickness

Biochemical Characterization of the Split Class II Ribonucleotide Reductase from Pseudomonas aeruginosa

Antitrypanosomal Activity of Anthriscus Nemorosa Essential Oils and Combinations of Their Main Constituents

Substrate kinetics and substrate effects on the quaternary structure of barley UDP-glucose pyrophosphorylase

Adenosine Kinase Mediates High Affinity Adenosine Salvage in Trypanosoma brucei

Quantification of all 12 canonical ribonucleotides by real-time fluorogenic in vitro transcription

Cryo-EM Reveals Promoter DNA Binding and Conformational Flexibility of the General Transcription Factor TFIID

The Ribonucleotide Reductase R1 Homolog of Murine Cytomegalovirus Is Not a Functional Enzyme Subunit but Is Required for Pathogenesis

Trypanosoma brucei CTP Synthetase: A Target for the Treatment of African Sleeping Sickness

Isocratic HPLC analysis for the simultaneous determination of dNTPs, rNTPs and ADP in biological samples

Mosquito control with green nanopesticides: towards the One Health approach? A review of non-target effects

Metabolic Fate of Oxidized Guanine Ribonucleotides in Mammalian Cells

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