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Discovery of small molecule cancer drugs: Successes, challenges and opportunities

Molecular oncology, 2012-04, Vol.6 (2), p.155-176

2012

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Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7346-7359

2012

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Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

Journal of medicinal chemistry, 2013-10, Vol.56 (20), p.8073-8088

2013

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High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers

Molecular cancer therapeutics, 2019-10, Vol.18 (10), p.1696-1707

2019

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Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches

Scientific reports, 2020-09, Vol.10 (1), p.16000-16000, Article 16000

2020

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Structure‐Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1

Chemistry : a European journal, 2017-07, Vol.23 (40), p.9577-9584

2017

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Structure-Based Design of Orally Bioavailable 1H‑Pyrrolo[3,2‑c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10045-10065

2013

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Structure of the Epigenetic Oncogene MMSET and Inhibition by N‑Alkyl Sinefungin Derivatives

ACS chemical biology, 2016-11, Vol.11 (11), p.3093-3105

2016

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Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane

Journal of organic chemistry, 2010-01, Vol.75 (1), p.11-15

2010

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An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

Molecular cell, 2009-11, Vol.36 (4), p.560-570

2009

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NMR Characterization of Kinase p38 Dynamics in Free and Ligand-Bound Forms

Angewandte Chemie (International ed.), 2006-01, Vol.45 (6), p.993-997

2006

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Design of Potent and Selective Hybrid Inhibitors of the Mitotic Kinase Nek2: Structure–Activity Relationship, Structural Biology, and Cellular Activity

Journal of medicinal chemistry, 2012-04, Vol.55 (7), p.3228-3241

2012

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Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization

Journal of medicinal chemistry, 2010-11, Vol.53 (21), p.7682-7698

2010

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Synthesis of amino-substituted indoles using the Bartoli reaction

Organic & biomolecular chemistry, 2012-06, Vol.10 (22), p.4441-4447

2012

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Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2

PloS one, 2013-06, Vol.8 (6), p.e65689-e65689

2013

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Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain‑4 (BRD4) by Tuning Kinase Selectivity

Journal of medicinal chemistry, 2019-03, Vol.62 (5), p.2618-2637

2019

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Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure–Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept

Journal of medicinal chemistry, 2018-08, Vol.61 (16), p.7261-7272

2018

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Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2553-2559

2015

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Expanding the scope of fused pyrimidines as kinase inhibitor scaffolds: synthesis and modification of pyrido[3,4-d]pyrimidines

Organic & biomolecular chemistry, 2015-01, Vol.13 (3), p.893-904

2015

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Fragment-based hit identification: thinking in 3D

Drug discovery today, 2013-12, Vol.18 (23-24), p.1221-1227

2013

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Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders

Journal of medicinal chemistry, 2020-04, Vol.63 (8), p.4047-4068

2020

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Determination of Ligand-Binding Affinity (K d) Using Transverse Relaxation Rate (R 2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery

Journal of medicinal chemistry, 2023-08, Vol.66 (15), p.10617-10627

2023

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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

Immunity (Cambridge, Mass.), 2024-07, Vol.57 (7), p.1514-1532.e15

2024

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Determination of Ligand-Binding Affinity ( K d ) Using Transverse Relaxation Rate ( R 2 ) in the Ligand-Observed 1 H NMR Experiment and Applications to Fragment-Based Drug Discovery

Journal of medicinal chemistry, 2023-08, Vol.66 (15), p.10617-10627

2023

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Discovery of small molecule cancer drugs: Successes, challenges and opportunities

Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers

Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches

Structure‐Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1

Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays

Structure-Based Design of Orally Bioavailable 1H‑Pyrrolo[3,2‑c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Structure of the Epigenetic Oncogene MMSET and Inhibition by N‑Alkyl Sinefungin Derivatives

Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

NMR Characterization of Kinase p38 Dynamics in Free and Ligand-Bound Forms

Design of Potent and Selective Hybrid Inhibitors of the Mitotic Kinase Nek2: Structure–Activity Relationship, Structural Biology, and Cellular Activity

Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization

Synthesis of amino-substituted indoles using the Bartoli reaction

Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2

Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain‑4 (BRD4) by Tuning Kinase Selectivity

Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure–Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept

Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B

Expanding the scope of fused pyrimidines as kinase inhibitor scaffolds: synthesis and modification of pyrido[3,4-d]pyrimidines

Fragment-based hit identification: thinking in 3D

Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders

Determination of Ligand-Binding Affinity (K d) Using Transverse Relaxation Rate (R 2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery

A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

Determination of Ligand-Binding Affinity ( K d ) Using Transverse Relaxation Rate ( R 2 ) in the Ligand-Observed 1 H NMR Experiment and Applications to Fragment-Based Drug Discovery

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