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Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease

The Journal of experimental medicine, 2015-03, Vol.212 (3), p.319-332

2015

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Pyridazine-derivatives Enhance Structural and Functional Plasticity of Tripartite Synapse Via Activation of Local Translation in Astrocytic Processes

Neuroscience, 2018-09, Vol.388, p.224-238

2018

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Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer's disease: a preclinical study in rTg4510 mice

Alzheimer's research & therapy, 2019-08, Vol.11 (1), p.75-19, Article 75

2019

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Restoring tripartite glutamatergic synapses: A potential therapy for mood and cognitive deficits in Gulf War illness

Neurobiology of stress, 2020-11, Vol.13, p.100240-100240, Article 100240

2020

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Nanotherapeutic approaches to overcome distinct drug resistance barriers in models of breast cancer

Nanophotonics (Berlin, Germany), 2021-09, Vol.10 (12), p.3063-3073

2021

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Small Molecules in Development for the Treatment of Spinal Muscular Atrophy

Journal of medicinal chemistry, 2016-11, Vol.59 (22), p.10067-10083

2016

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Barcoded viral tracing of single-cell interactions in central nervous system inflammation

Science (American Association for the Advancement of Science), 2021-04, Vol.372 (6540)

2021

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Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy

NPJ Parkinson's Disease, 2022-06, Vol.8 (1), p.74-74, Article 74

2022

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Identification of environmental factors that promote intestinal inflammation

Nature (London), 2022-11, Vol.611 (7937), p.801-809

2022

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Ethyl 2-Chlorooxazole-4-carboxylate: A Versatile Intermediate for the Synthesis of Substituted Oxazoles

Organic letters, 2002-08, Vol.4 (17), p.2905-2907

2002

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Discovery of N-(1-Ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98−2): An Orally Active Corticotropin Releasing Factor-1 (CRF-1) Receptor Antagonist

Journal of medicinal chemistry, 2011-06, Vol.54 (12), p.4187-4206

2011

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Inter- and intramolecular Mitsunobu reaction based approaches to 2-substituted chromans and chroman-4-ones

Tetrahedron, 2005-07, Vol.61 (28), p.6860-6870

Hodgetts, Kevin J.

2005

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Approaches to 2-substituted chroman-4-ones: synthesis of (−)-pinostrobin

Tetrahedron letters, 2001-05, Vol.42 (22), p.3763-3766

Hodgetts, Kevin J

2001

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Small Molecules in Development for the Treatment of Spinal Muscular Atrophy: Miniperspective

Journal of medicinal chemistry, 2016-11, Vol.59 (22), p.10067-10083

2016

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Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy

Journal of medicinal chemistry, 2017-06, Vol.60 (11), p.4594-4610

2017

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The design, synthesis and structure–activity relationships of 1-aryl-4-aminoalkylisoquinolines: A novel series of CRF-1 receptor antagonists

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.891-896

2008

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Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers

Bioorganic & medicinal chemistry letters, 2017-12, Vol.27 (23), p.5144-5148

2017

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Short-duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy

Life science alliance, 2021-01, Vol.4 (1), p.e202000889

2021

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Synthesis of 2-Aryl-oxazolo[4,5-c]quinoline-4(5H)-ones and 2-Aryl-thiazolo[4,5-c]quinoline-4(5H)-ones

Organic letters, 2003-08, Vol.5 (16), p.2911-2914

2003

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Discovery of Novel 6,6-Heterocycles as Transient Receptor Potential Vanilloid (TRPV1) Antagonists

Journal of medicinal chemistry, 2010-04, Vol.53 (8), p.3330-3348

2010

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Conjugate addition to 3-arylsulfinylchromones as a synthetic route to homochiral 2-substituted chromanones: scope and limitations

Tetrahedron, 2001-07, Vol.57 (31), p.6793-6804

2001

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Regiocontrolled Synthesis of Substituted Thiazoles

Organic letters, 2002-04, Vol.4 (8), p.1363-1365

2002

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Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (15), p.4359-4363

2010

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Aminoquinazolines as TRPV1 antagonists: Modulation of drug-like properties through the exploration of 2-position substitution

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (16), p.4573-4577

2008

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From arylureas to biarylamides to aminoquinazolines: Discovery of a novel, potent TRPV1 antagonist

Bioorganic & medicinal chemistry letters, 2006-10, Vol.16 (19), p.5217-5221

2006

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Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease

Pyridazine-derivatives Enhance Structural and Functional Plasticity of Tripartite Synapse Via Activation of Local Translation in Astrocytic Processes

Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer's disease: a preclinical study in rTg4510 mice

Restoring tripartite glutamatergic synapses: A potential therapy for mood and cognitive deficits in Gulf War illness

Nanotherapeutic approaches to overcome distinct drug resistance barriers in models of breast cancer

Small Molecules in Development for the Treatment of Spinal Muscular Atrophy

Barcoded viral tracing of single-cell interactions in central nervous system inflammation

Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy

Identification of environmental factors that promote intestinal inflammation

Ethyl 2-Chlorooxazole-4-carboxylate: A Versatile Intermediate for the Synthesis of Substituted Oxazoles

Discovery of N-(1-Ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98−2): An Orally Active Corticotropin Releasing Factor-1 (CRF-1) Receptor Antagonist

Inter- and intramolecular Mitsunobu reaction based approaches to 2-substituted chromans and chroman-4-ones

Approaches to 2-substituted chroman-4-ones: synthesis of (−)-pinostrobin

Small Molecules in Development for the Treatment of Spinal Muscular Atrophy: Miniperspective

Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy

The design, synthesis and structure–activity relationships of 1-aryl-4-aminoalkylisoquinolines: A novel series of CRF-1 receptor antagonists

Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers

Short-duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy

Synthesis of 2-Aryl-oxazolo[4,5-c]quinoline-4(5H)-ones and 2-Aryl-thiazolo[4,5-c]quinoline-4(5H)-ones

Discovery of Novel 6,6-Heterocycles as Transient Receptor Potential Vanilloid (TRPV1) Antagonists

Conjugate addition to 3-arylsulfinylchromones as a synthetic route to homochiral 2-substituted chromanones: scope and limitations

Regiocontrolled Synthesis of Substituted Thiazoles

Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites

Aminoquinazolines as TRPV1 antagonists: Modulation of drug-like properties through the exploration of 2-position substitution

From arylureas to biarylamides to aminoquinazolines: Discovery of a novel, potent TRPV1 antagonist

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