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Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.6876-6897

2020

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Novel potent and highly selective DDR1 inhibitors from integrated lead finding

Medicinal chemistry research, 2023-07, Vol.32 (7), p.1400-1425

2023

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Analysis of Current DNA Encoded Library Screening Data Indicates Higher False Negative Rates for Numerically Larger Libraries

ACS combinatorial science, 2017-04, Vol.19 (4), p.234-238

2017

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Melting of a DNA helix terminus within the active site of a DNA polymerase

Biochemistry (Easton), 1994-10, Vol.33 (39), p.11971-11979

1994

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β‑Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

Journal of medicinal chemistry, 2013-05, Vol.56 (10), p.3980-3995

2013

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Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors

Angewandte Chemie (International ed.), 2014-02, Vol.53 (6), p.1704-1708

2014

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Discovery of Orally Available and Brain Penetrant AEP Inhibitors

Journal of medicinal chemistry, 2023-12, Vol.66 (24), p.17026-17043

2023

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Dynamics of mismatched base pairs in DNA

Biochemistry (Easton), 1991-04, Vol.30 (13), p.3271-3279

1991

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Proofreading DNA: Recognition of Aberrant DNA Termini by the Klenow Fragment of DNA Polymerase I

Proceedings of the National Academy of Sciences - PNAS, 1994-10, Vol.91 (22), p.10670-10674

1994

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SiLA: Basic Standards for Rapid Integration in Laboratory Automation

Journal of Laboratory Automation, 2012-04, Vol.17 (2), p.86-95

2012

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Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of [beta]-Secretase (BACE1) Inhibitors

Angewandte Chemie International Edition, 2014-02, Vol.53 (6), p.1704

International ed. in English, 2014

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Inside Cover: Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors (Angew. Chem. Int. Ed. 6/2014)

Angewandte Chemie (International ed.), 2014-02, Vol.53 (6), p.1452-1452

2014

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Inside Cover: Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of [beta]-Secretase (BACE1) Inhibitors (Angew. Chem. Int. Ed. 6/2014)

Angewandte Chemie International Edition, 2014-02, Vol.53 (6), p.1452

International ed. in English, 2014

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Synthesis and biological evaluation of 3-aryltyramines as fragments binding to BACE-1 and BACE-2

Tetrahedron letters, 2012-04, Vol.53 (17), p.2189-2194

2012

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Nahtlose Integration von Dosis-Wirkungs-basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur-Aktivitäts-Beziehungen von [beta]-Sekretase(BACE1)-Hemmern

Angewandte Chemie, 2014-02, Vol.126 (6), p.1730

2014

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Innentitelbild: Nahtlose Integration von Dosis-Wirkungs-basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur-Aktivitäts-Beziehungen von β-Sekretase(BACE1)-Hemmern (Angew. Chem. 6/2014)

Angewandte Chemie, 2014-02, Vol.126 (6), p.1476-1476

2014

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Nahtlose Integration von Dosis-Wirkungs-basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur-Aktivitäts-Beziehungen von β-Sekretase(BACE1)-Hemmern

Angewandte Chemie, 2014-02, Vol.126 (6), p.1730-1735

2014

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Interaction of DNA with the Klenow fragment of DNA polymerase I studied by time-resolved fluorescence spectroscopy

Biochemistry (Easton), 1991-09, Vol.30 (36), p.8759-8770

1991

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High-Resolution Capillary Tube NMR. A Miniaturized 5-μL High-Sensitivity TXI Probe for Mass-Limited Samples, Off-Line LC NMR, and HT NMR

Analytical chemistry (Washington), 2002-09, Vol.74 (17), p.4464-4471

2002

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Biosensors in Biomedical Research: Development and Applications of Gene Chips

Chimia, 1999-01, Vol.53 (3), p.57

1999

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Characterization of amino acid side chain dynamics in a zinc-finger peptide using carbon-13 NMR spectroscopy and time-resolved fluorescence spectroscopy

Journal of the American Chemical Society, 1993-07, Vol.115 (14), p.6333-6345

1993

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Distance distribution in a dye-linked oligonucleotide determined by time-resolved fluorescence energy transfer

Biophysical chemistry, 1992-12, Vol.45 (2), p.133-141

1992

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Tris-benzimidazole derivatives : Design, synthesis and DNA sequence recognition

Bioorganic & medicinal chemistry, 2001-11, Vol.9 (11), p.2905-2919

2001

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High-resolution capillary tube NMR. A miniaturized 5-muL high-sensitivity TXI probe for mass-limited samples, off-line LC NMR, and HT NMR

Analytical chemistry (Washington), 2002-09, Vol.74 (17), p.4464

2002

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DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome

Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Novel potent and highly selective DDR1 inhibitors from integrated lead finding

Analysis of Current DNA Encoded Library Screening Data Indicates Higher False Negative Rates for Numerically Larger Libraries

Melting of a DNA helix terminus within the active site of a DNA polymerase

β‑Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors

Discovery of Orally Available and Brain Penetrant AEP Inhibitors

Dynamics of mismatched base pairs in DNA

Proofreading DNA: Recognition of Aberrant DNA Termini by the Klenow Fragment of DNA Polymerase I

SiLA: Basic Standards for Rapid Integration in Laboratory Automation

Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of [beta]-Secretase (BACE1) Inhibitors

Inside Cover: Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors (Angew. Chem. Int. Ed. 6/2014)

Inside Cover: Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of [beta]-Secretase (BACE1) Inhibitors (Angew. Chem. Int. Ed. 6/2014)

Synthesis and biological evaluation of 3-aryltyramines as fragments binding to BACE-1 and BACE-2

Nahtlose Integration von Dosis-Wirkungs-basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur-Aktivitäts-Beziehungen von [beta]-Sekretase(BACE1)-Hemmern

Innentitelbild: Nahtlose Integration von Dosis-Wirkungs-basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur-Aktivitäts-Beziehungen von β-Sekretase(BACE1)-Hemmern (Angew. Chem. 6/2014)

Nahtlose Integration von Dosis-Wirkungs-basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur-Aktivitäts-Beziehungen von β-Sekretase(BACE1)-Hemmern

Interaction of DNA with the Klenow fragment of DNA polymerase I studied by time-resolved fluorescence spectroscopy

High-Resolution Capillary Tube NMR. A Miniaturized 5-μL High-Sensitivity TXI Probe for Mass-Limited Samples, Off-Line LC NMR, and HT NMR

Biosensors in Biomedical Research: Development and Applications of Gene Chips

Characterization of amino acid side chain dynamics in a zinc-finger peptide using carbon-13 NMR spectroscopy and time-resolved fluorescence spectroscopy

Distance distribution in a dye-linked oligonucleotide determined by time-resolved fluorescence energy transfer

Tris-benzimidazole derivatives : Design, synthesis and DNA sequence recognition

High-resolution capillary tube NMR. A miniaturized 5-muL high-sensitivity TXI probe for mass-limited samples, off-line LC NMR, and HT NMR

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