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Adapting ADME and Pharmacokinetic Analysis to the Next Generation of Therapeutic Modalities

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.35-41

Hochman, Jerome H.

2021

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RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice

Molecular pharmacology, 2011-06, Vol.79 (6), p.953-963

2011

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Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys

Biochemical pharmacology, 2009-09, Vol.78 (6), p.642-647

2009

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Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.4057-4061

2007

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First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates

The Journal of pharmacology and experimental therapeutics, 2009-01, Vol.328 (1), p.131-140

2009

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Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin

Pharmaceutical research, 2004-09, Vol.21 (9), p.1686-1691

2004

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In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results

The Journal of pharmacology and experimental therapeutics, 2001-03, Vol.296 (3), p.723

2001

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Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein

Current drug metabolism, 2002-06, Vol.3 (3), p.257-273

2002

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Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4

The Journal of pharmacology and experimental therapeutics, 2000-01, Vol.292 (1), p.310

2000

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Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1788-1792

2007

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Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.5831-5835

2007

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Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (24), p.6165-6169

2006

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P-glycoprotein-mediated efflux of indinavir metabolites in Caco-2 cells expressing cytochrome P450 3A4

The Journal of pharmacology and experimental therapeutics, 2001-07, Vol.298 (1), p.323

2001

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Development and characterization of LLC-PK1 cells containing Sprague–Dawley rat Abcb1a ( Mdr1a): Comparison of rat P-glycoprotein transport to human and mouse

Journal of pharmacological and toxicological methods, 2006-07, Vol.54 (1), p.78-89

2006

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Acyl glucuronidation and glucosidation of a new and selective endothelin ET(A) receptor antagonist in human liver microsomes

Drug metabolism and disposition, 2003-01, Vol.31 (1), p.37-45

2003

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Comparison of imidazole- and 2-methyl imidazole-containing farnesyl-protein transferase inhibitors: interaction with and metabolism by rat hepatic cytochrome P450s

Drug metabolism and disposition, 2000-06, Vol.28 (6), p.680

2000

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Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells

Drug metabolism and disposition, 1996-06, Vol.24 (6), p.634

1996

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Establishment of P‐Glycoprotein Structure–Transport Relationships to Optimize CNS Exposure in Drug Discovery

Blood‐Brain Barrier in Drug Discovery, 2015, p.113-124

2015

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Simultaneous in vitro measurement of intestinal tissue permeability and transepithelial electrical resistance (TEER) using sweetana-grass diffusion cells

Pharmaceutical research, 1992-03, Vol.9 (3), p.316-319

1992

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Preface

Advanced drug delivery reviews, 1996-11, Vol.22 (1-2), p.1

1996

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Cultured rat hepatocytes

Pharmaceutical biotechnology, 1996, Vol.8, p.121

1996

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Cell cultures to assess drug transport and metabolism

Advanced drug delivery reviews, 1996, Vol.22 (1-2)

1996

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Endocytosis and dissociation of class I MHC molecules labeled with fluorescent beta-2 microglobulin

The Journal of immunology (1950), 1991-03, Vol.146 (6), p.1862-1867

1991

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Species and organ differences in first-pass metabolism of the ester prodrug L-751,164 in dogs and monkeys. In vivo and in vitro studies

Drug metabolism and disposition, 1996-11, Vol.24 (11), p.1263

1996

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Adapting ADME and Pharmacokinetic Analysis to the Next Generation of Therapeutic Modalities

RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates

Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin

In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results

Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein

siRNA-Mediated Knockdown of P450 Oxidoreductase in Rats: A Tool to Reduce Metabolism by CYPs and Increase Exposure of High Clearance Compounds

Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation

Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors

Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists

P-glycoprotein-mediated efflux of indinavir metabolites in Caco-2 cells expressing cytochrome P450 3A4

Development and characterization of LLC-PK1 cells containing Sprague–Dawley rat Abcb1a ( Mdr1a): Comparison of rat P-glycoprotein transport to human and mouse

Acyl glucuronidation and glucosidation of a new and selective endothelin ET(A) receptor antagonist in human liver microsomes

Comparison of imidazole- and 2-methyl imidazole-containing farnesyl-protein transferase inhibitors: interaction with and metabolism by rat hepatic cytochrome P450s

Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells

Establishment of P‐Glycoprotein Structure–Transport Relationships to Optimize CNS Exposure in Drug Discovery

Simultaneous in vitro measurement of intestinal tissue permeability and transepithelial electrical resistance (TEER) using sweetana-grass diffusion cells

Preface

Cultured rat hepatocytes

Cell cultures to assess drug transport and metabolism

Endocytosis and dissociation of class I MHC molecules labeled with fluorescent beta-2 microglobulin

Species and organ differences in first-pass metabolism of the ester prodrug L-751,164 in dogs and monkeys. In vivo and in vitro studies

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