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Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol

The Journal of biological chemistry, 2015-02, Vol.290 (8), p.4573-4589

2015

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Discovery of A‑971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders

Journal of medicinal chemistry, 2015-12, Vol.58 (23), p.9154-9170

2015

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The medicinal chemistry evolution of antibody-drug conjugates

RSC medicinal chemistry, 2024-03, Vol.15 (3), p.89-831

Hobson, Adrian D

2024

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Pushing the Envelope: Advancement of ADCs Outside of Oncology

Methods in molecular biology (Clifton, N.J.), 2020-01, Vol.2078, p.23

2020

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Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties

RSC medicinal chemistry, 2024-03, Vol.15 (3), p.832-838

2024

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Impact of drug-linker on method selection for analytical characterization and purification of antibody-drug conjugates

Analytical methods, 2024-06, Vol.16 (22), p.3492-353

2024

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Correction: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties

RSC medicinal chemistry, 2024-03, Vol.15 (3), p.172-172

2024

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Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads

Journal of medicinal chemistry, 2022-03, Vol.65 (6), p.4500-4533

2022

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Optimization of Drug-Linker to Enable Long-term Storage of Antibody–Drug Conjugate for Subcutaneous Dosing

Journal of medicinal chemistry, 2023-07, Vol.66 (13), p.9161-9173

2023

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Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody–Drug Conjugates

Bioconjugate chemistry, 2023-10, Vol.34 (10), p.1835-1850

2023

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Impact of atropisomerism on a non-steroidal glucocorticoid receptor agonist

RSC medicinal chemistry, 2024-07, Vol.15 (7), p.2357-2371

2024

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Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC)

Journal of medicinal chemistry, 2023-09, Vol.66 (17), p.12544-12558

2023

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Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate

Journal of medicinal chemistry, 2022-12, Vol.65 (23), p.15893-15934

2022

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An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases

Science translational medicine, 2024-03, Vol.16 (739), p.eadd8936

2024

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Impact of dipeptide on ADC physicochemical properties and efficacy identifies Ala-Ala as the optimal dipeptide

RSC medicinal chemistry, 2024-01, Vol.15 (1), p.355-365

2024

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Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.417-429

2021

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Correction to “Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads”

Journal of medicinal chemistry, 2023-04, Vol.66 (8), p.6011-6011

2023

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Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates

RSC medicinal chemistry, 2024-02, Vol.15 (2), p.612-622

2024

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Correction to “Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate”

Journal of medicinal chemistry, 2023-04, Vol.66 (8), p.6010-6010

2023

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Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design

Journal of medicinal chemistry, 2018-12, Vol.61 (24), p.11074-11100

2018

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Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate

Chembiochem : a European journal of chemical biology, 2018-03, Vol.19 (6), p.613-621

2018

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Corrigendum: Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate

Chembiochem : a European journal of chemical biology, 2018-04, Vol.19 (8), p.890-890

2018

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Lewis Acid Catalyzed Cyclizations of Epoxidized Baylis-Hillman Products: A Straightforward Synthesis of Octahydrobenzo[e]azulenes

European journal of organic chemistry, 2015-08, Vol.2015 (24), p.5453-5463

2015

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Highly diastereoselective 1,3-dipolar cycloaddition reactions of trans-2-methylene-1,3-dithiolane 1,3-dioxide with 3-oxidopyridinium and 3-oxidopyrylium betaines: a route to the tropane skeleton

Organic & biomolecular chemistry, 2003-06, Vol.1 (11), p.1884-1893

2003

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Stereoselective construction of quaternary centers at ambient temperature by the highly stereocontrolled migration of groups containing sp-, sp2-, and sp3-hybridized carbon atoms

Journal of organic chemistry, 1993-10, Vol.58 (22), p.5944-5951

1993

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Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol

Discovery of A‑971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders

The medicinal chemistry evolution of antibody-drug conjugates

Pushing the Envelope: Advancement of ADCs Outside of Oncology

Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties

Impact of drug-linker on method selection for analytical characterization and purification of antibody-drug conjugates

Correction: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties

Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads

Optimization of Drug-Linker to Enable Long-term Storage of Antibody–Drug Conjugate for Subcutaneous Dosing

Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody–Drug Conjugates

Impact of atropisomerism on a non-steroidal glucocorticoid receptor agonist

Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC)

Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate

An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases

Impact of dipeptide on ADC physicochemical properties and efficacy identifies Ala-Ala as the optimal dipeptide

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design

Correction to “Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads”

Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates

Correction to “Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate”

Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design

Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate

Corrigendum: Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate

Lewis Acid Catalyzed Cyclizations of Epoxidized Baylis-Hillman Products: A Straightforward Synthesis of Octahydrobenzo[e]azulenes

Highly diastereoselective 1,3-dipolar cycloaddition reactions of trans-2-methylene-1,3-dithiolane 1,3-dioxide with 3-oxidopyridinium and 3-oxidopyrylium betaines: a route to the tropane skeleton

Stereoselective construction of quaternary centers at ambient temperature by the highly stereocontrolled migration of groups containing sp-, sp2-, and sp3-hybridized carbon atoms

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