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Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development

Drug development research, 2023-09, Vol.84 (6), p.1085-1095

2023

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Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function

Annals of neurology, 2020-09, Vol.88 (3), p.513-525

2020

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Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Nature reviews. Neurology, 2018-03, Vol.14 (3), p.168

2018

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The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease

Alzheimer's & dementia, 2014-02, Vol.10 (1), p.S12-S25

2014

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Simufilam Reverses Aberrant Receptor Interactions of Filamin A in Alzheimer’s Disease

International journal of molecular sciences, 2023-09, Vol.24 (18), p.13927

2023

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mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia

Molecular psychiatry, 2020-04, Vol.25 (4), p.750-760

2020

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Prenatal Cocaine Exposure Upregulates BDNF-TrkB Signaling

PloS one, 2016-08, Vol.11 (8), p.e0160585

2016

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Brain insulin signaling and cerebrovascular disease in human postmortem brain

Alzheimer's & dementia, 2021-12, Vol.17, p.e052253-n/a

2021

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Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4

Molecular neurodegeneration, 2021-04, Vol.16 (1), p.1-26

2021

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Cortical Plasticity in Alzheimer’s Disease in Humans and Rodents

Biological psychiatry (1969), 2007-12, Vol.62 (12), p.1405-1412

2007

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Naloxone's pentapeptide binding site on filamin A blocks Mu opioid receptor-Gs coupling and CREB activation of acute morphine

PloS one, 2009-01, Vol.4 (1), p.e4282-e4282

2009

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Pathway analysis of glutamate-mediated, calcium-related signaling in glioma progression

Biochemical pharmacology, 2020-06, Vol.176, p.113814-113814, Article 113814

2020

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Isoflurane increases neuronal cell death vulnerability by downregulating miR-214

PloS one, 2013-02, Vol.8 (2), p.e55276-e55276

2013

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High-affinity naloxone binding to filamin a prevents mu opioid receptor-Gs coupling underlying opioid tolerance and dependence

PloS one, 2008-02, Vol.3 (2), p.e1554

2008

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Brain insulin signaling and cerebrovascular disease in human postmortem brain

Acta neuropathologica communications, 2021-04, Vol.9 (1), p.71-71, Article 71

2021

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Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer's disease patient lymphocytes

Frontiers in aging, 2023-06, Vol.4, p.1175601-1175601

2023

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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

The Journal of clinical investigation, 2012-04, Vol.122 (4), p.1316-1338

2012

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Prenatal cocaine exposure uncouples mGluR1 from Homer1 and Gq Proteins

PloS one, 2014-03, Vol.9 (3), p.e91671

2014

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The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses

PloS one, 2009-04, Vol.4 (4), p.e5251-e5251

2009

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PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis

Neurobiology of aging, 2017-07, Vol.55, p.99-114

2017

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Stimulated D1 dopamine receptors couple to multiple Gα proteins in different brain regions

Journal of neurochemistry, 2001-09, Vol.78 (5), p.981-990

2001

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Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis

Alzheimer's research & therapy, 2017-07, Vol.9 (1), p.1-17

2017

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A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling

Physiology & behavior, 2021-05, Vol.234, p.113286-113286, Article 113286

2021

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Stress Diminishes BDNF-stimulated TrkB Signaling, TrkB-NMDA Receptor Linkage and Neuronal Activity in the Rat Brain

Neuroscience, 2021-10, Vol.473, p.142-158

2021

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Prenatal cocaine exposure increases synaptic localization of a neuronal RasGEF, GRASP-1 via hyperphosphorylation of AMPAR anchoring protein, GRIP

PloS one, 2011-09, Vol.6 (9), p.e25019

2011

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Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development

Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease

Simufilam Reverses Aberrant Receptor Interactions of Filamin A in Alzheimer’s Disease

mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia

Prenatal Cocaine Exposure Upregulates BDNF-TrkB Signaling

Brain insulin signaling and cerebrovascular disease in human postmortem brain

Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4

Cortical Plasticity in Alzheimer’s Disease in Humans and Rodents

Naloxone's pentapeptide binding site on filamin A blocks Mu opioid receptor-Gs coupling and CREB activation of acute morphine

Pathway analysis of glutamate-mediated, calcium-related signaling in glioma progression

Isoflurane increases neuronal cell death vulnerability by downregulating miR-214

High-affinity naloxone binding to filamin a prevents mu opioid receptor-Gs coupling underlying opioid tolerance and dependence

Brain insulin signaling and cerebrovascular disease in human postmortem brain

Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer's disease patient lymphocytes

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Prenatal cocaine exposure uncouples mGluR1 from Homer1 and Gq Proteins

The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses

PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis

Stimulated D1 dopamine receptors couple to multiple Gα proteins in different brain regions

Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis

A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling

Stress Diminishes BDNF-stimulated TrkB Signaling, TrkB-NMDA Receptor Linkage and Neuronal Activity in the Rat Brain

Prenatal cocaine exposure increases synaptic localization of a neuronal RasGEF, GRASP-1 via hyperphosphorylation of AMPAR anchoring protein, GRIP

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