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Synthesis and functional characterization of substituted isoquinolinones as MT2-selective melatoninergic ligands

PloS one, 2014-12, Vol.9 (12), p.e113638-e113638

2014

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Characterization of substituted phenylpropylamides as highly selective agonists at the melatonin MT2 receptor

Current medicinal chemistry, 2013, Vol.20 (2), p.289-300

2013

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Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types

Planta medica, 2012-01, Vol.78 (2), p.115-121

2012

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Pharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats

Xenobiotica, 2012-11, Vol.42 (11), p.1138-1150

2012

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In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator

DRUG METABOLISM AND PHARMACOKINETICS, 2010-01, Vol.25 (5), p.477-486

2010

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Gα14 links a variety of Gi‐ and Gs‐coupled receptors to the stimulation of phospholipase C

British journal of pharmacology, 2001-04, Vol.132 (7), p.1431-1440

2001

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Characterization of Substituted Phenylpropylamides as Highly Selective Agonists at the Melatonin MT2 Receptor

Current medicinal chemistry, 2012-12, Vol.20 (2), p.289-300

2012

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3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic properties

Xenobiotica, 2011-01, Vol.41 (1), p.35-45

2011

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Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT2-selective melatonin ligands

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2582-2585

2010

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Expression of Gα(z) in C2C12 cells restrains myogenic differentiation

Cellular signalling, 2011-02, Vol.23 (2), p.389-397

2011

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Gz signaling: emerging divergence from Gi signaling

Oncogene, 2001-03, Vol.20 (13), p.1615-1625

2001

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In search of novel and therapeutically significant melatoninergic ligands

Recent patents on CNS drug discovery, 2007-11, Vol.2 (3), p.241-245

2007

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Synthesis and Functional Characterization of Substituted Isoquinolinones as MT.sub.2-Selective Melatoninergic Ligands

PloS one, 2014-12, Vol.9 (12)

2014

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Identification of a stretch of six divergent amino acids on the alpha5 helix of Galpha16 as a major determinant of the promiscuity and efficiency of receptor coupling

Biochemical journal, 2004-06, Vol.380 (Pt 2), p.361-369

2004

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Gz signaling: emerging divergence from Gi signaling

Oncogene, 2001-03, Vol.20 (13), p.1615-1625

2001

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Gα 14 links a variety of G i ‐ and G s ‐coupled receptors to the stimulation of phospholipase C

British journal of pharmacology, 2009-01, Vol.132 (7), p.1431-1440

2009

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Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT sub(2)-selective melatonin ligands

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2582-2585

2010

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Mutations on the Switch III region and the alpha3 helix of Galpha16 differentially affect receptor coupling and regulation of downstream effectors

Journal of molecular signaling, 2008-11, Vol.3 (1), p.17-17

2008

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A Hematopoietic Perspective on the Promiscuity and Specificity of G alpha 16 Signaling

Neuro-Signals, 2009-02, Vol.17 (1), p.71-81

2009

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Ga sub(16) activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS)

Cellular signalling, 2010-10, Vol.22 (10), p.1448-1458

2010

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A hematopoietic perspective on the promiscuity and specificity of Galpha16 signaling

Neuro-Signals, 2009, Vol.17 (1), p.71-81

2009

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Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2582-2585

2010

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G[alpha].sub.16 interacts with tetratricopeptide repeat 1

BMC structural biology, 2011-04, Vol.11, p.17

2011

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G[alpha].sub.16 interacts with tetratricopeptide repeat 1 through its [beta]3 region to activate Ras independently of phospholipase C[beta] signaling

BMC structural biology, 2011-04, Vol.11, p.17

2011

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The beta6/alpha5 regions of Galphai2 and GalphaoA increase the promiscuity of Galpha16 but are insufficient for pertussis toxin-catalyzed ADP-ribosylation

European journal of pharmacology, 2003-07, Vol.473 (2-3), p.105-115

2003

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Synthesis and functional characterization of substituted isoquinolinones as MT2-selective melatoninergic ligands

Characterization of substituted phenylpropylamides as highly selective agonists at the melatonin MT2 receptor

Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types

Pharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats

In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator

Gα14 links a variety of Gi‐ and Gs‐coupled receptors to the stimulation of phospholipase C

Characterization of Substituted Phenylpropylamides as Highly Selective Agonists at the Melatonin MT2 Receptor

3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic properties

Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT2-selective melatonin ligands

Expression of Gα(z) in C2C12 cells restrains myogenic differentiation

Gz signaling: emerging divergence from Gi signaling

In search of novel and therapeutically significant melatoninergic ligands

Synthesis and Functional Characterization of Substituted Isoquinolinones as MT.sub.2-Selective Melatoninergic Ligands

Identification of a stretch of six divergent amino acids on the alpha5 helix of Galpha16 as a major determinant of the promiscuity and efficiency of receptor coupling

Gz signaling: emerging divergence from Gi signaling

Gα 14 links a variety of G i ‐ and G s ‐coupled receptors to the stimulation of phospholipase C

Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT sub(2)-selective melatonin ligands

Mutations on the Switch III region and the alpha3 helix of Galpha16 differentially affect receptor coupling and regulation of downstream effectors

A Hematopoietic Perspective on the Promiscuity and Specificity of G alpha 16 Signaling

Ga sub(16) activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS)

A hematopoietic perspective on the promiscuity and specificity of Galpha16 signaling

Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands

G[alpha].sub.16 interacts with tetratricopeptide repeat 1

G[alpha].sub.16 interacts with tetratricopeptide repeat 1 through its [beta]3 region to activate Ras independently of phospholipase C[beta] signaling

The beta6/alpha5 regions of Galphai2 and GalphaoA increase the promiscuity of Galpha16 but are insufficient for pertussis toxin-catalyzed ADP-ribosylation

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