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Pharma challenges to adoption of microphysiological system in drug research and development, especially safety assessment

Folia Pharmacologica Japonica, 2023, Vol.158(2), pp.187-192

Naraoka, Hitoshi

2023

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Usefulness of a humanized tricellular static transwell blood–brain barrier model as a microphysiological system for drug development applications. - A case study based on the benchmark evaluations of blood-brain barrier microphysiological system

Regenerative therapy, 2023-03, Vol.22, p.192-202

2023

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Progression process and safety assessment adaptation of endometrial lesions in ENU-induced 2-stage uterine carcinogenicity in a Tg-rasH2 mouse model

Journal of Toxicologic Pathology, 2018, Vol.31(1), pp.35-41

2018

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Metabolic Profiling to Identify Potential Serum Biomarkers for Gastric Ulceration Induced by Nonsteroid Anti-Inflammatory Drugs

Journal of proteome research, 2013-03, Vol.12 (3), p.1399-1407

2013

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Cardiotoxicity evaluation using three-dimensional cardiac tissues consisting of human iPS cell-derived cardiomyocytes and fibroblasts by cell coating technique

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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Metabolomic analysis of the effects of omeprazole and famotidine on aspirin-induced gastric injury

Metabolomics, 2014-10, Vol.10 (5), p.995-1004

2014

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Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin

Biomarker Insights, 2014-01, Vol.2014 (9), p.61-66

2014

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医薬品研究開発におけるMicrophysiological systems（MPS）研究の現状―安全性評価を中心に

日本薬理学雑誌, 2023, Vol.158(2), pp.187-192

奈良岡, 準

2023

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Evaluation of H-FABP as a marker of ongoing myocardial damage using hGH transgenic mice

Clinica chimica acta, 2005-11, Vol.361 (1), p.159-166

2005

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Analysis of Gender Difference of Cardiac Risk Biomarkers Using hGH-Transgenic Mice

Experimental Animals, 2006, Vol.55(1), pp.1-9

2006

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Investigation of Mechanisms for MK-801-Induced Neurotoxicity Utilizing Metabolomic Approach

Toxicological sciences, 2015-08, Vol.146 (2), p.344-353

2015

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S6-3. MPS development based on End-user's Needs

Alternatives to Animal Testing and Experimentation, 2021-12, Vol.26 (suppl), p.102-102

Hitoshi Naraoka

2021

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Consideration for the validation of clinical laboratory methods in nonclinical fields

Bioanalysis, 2022-11, Vol.14 (21), p.1337-1348

2022

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[18F]FDG-PET as an imaging biomarker to NMDA receptor antagonist-induced neurotoxicity

Toxicological sciences, 2013-05, Vol.133 (1), p.13-21

2013

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Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin

Biomarker insights, 2014-01, Vol.9

2014

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WS1-6 Investigation of Toxicological Biomarker Discovery by Imaging Mass Spectolometry

Journal of Toxicologic Pathology, 2009, Vol.22 (suppl), p.5-5

2009

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Role of biomarkers in toxicity treatment "metabonomics" as a new biomarker discovery method

Rinsho byori. The Japanese journal of clinical pathology, 2008-04, Vol.56 (4), p.335

2008

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P-71. Cardiotoxicity and drug response evaluation using LbL-3D Heart composed of human iPS cell-derived cardiomyocyte

Alternatives to Animal Testing and Experimentation, 2018-12, Vol.23 (suppl), p.144-144

2018

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Efficiency improvement of fluorescent blue device by molecular orientation of blue dopant

Journal of the Society for Information Display, 2014-01, Vol.22 (1), p.76-82

2014

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Molecular-isotopic stratigraphy of long-chain n-alkanes in Lake Baikal Holocene and glacial age sediments

Organic geochemistry, 2000-04, Vol.31 (4), p.287-294

2000

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37.2: Efficiency Improvement of Fluorescent Blue Device by Molecular Orientation of Blue Dopant

SID International Symposium Digest of technical papers, 2013-06, Vol.44 (1), p.515-518

2013

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56.4: New Deep Blue Fluorescent Materials and Their Application to High Performance OLEDs

SID International Symposium Digest of technical papers, 2011-06, Vol.42 (1), p.829-832

2011

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Pharma challenges to adoption of microphysiological system in drug research and development, especially safety assessment

Usefulness of a humanized tricellular static transwell blood–brain barrier model as a microphysiological system for drug development applications. - A case study based on the benchmark evaluations of blood-brain barrier microphysiological system

Progression process and safety assessment adaptation of endometrial lesions in ENU-induced 2-stage uterine carcinogenicity in a Tg-rasH2 mouse model

Metabolic Profiling to Identify Potential Serum Biomarkers for Gastric Ulceration Induced by Nonsteroid Anti-Inflammatory Drugs

Cardiotoxicity evaluation using three-dimensional cardiac tissues consisting of human iPS cell-derived cardiomyocytes and fibroblasts by cell coating technique

Metabolomic analysis of the effects of omeprazole and famotidine on aspirin-induced gastric injury

Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin

医薬品研究開発におけるMicrophysiological systems（MPS）研究の現状―安全性評価を中心に

Evaluation of H-FABP as a marker of ongoing myocardial damage using hGH transgenic mice

Analysis of Gender Difference of Cardiac Risk Biomarkers Using hGH-Transgenic Mice

Investigation of Mechanisms for MK-801-Induced Neurotoxicity Utilizing Metabolomic Approach

S6-3. MPS development based on End-user's Needs

Consideration for the validation of clinical laboratory methods in nonclinical fields

[18F]FDG-PET as an imaging biomarker to NMDA receptor antagonist-induced neurotoxicity

Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin

WS1-6 Investigation of Toxicological Biomarker Discovery by Imaging Mass Spectolometry

Role of biomarkers in toxicity treatment "metabonomics" as a new biomarker discovery method

P-71. Cardiotoxicity and drug response evaluation using LbL-3D Heart composed of human iPS cell-derived cardiomyocyte

Efficiency improvement of fluorescent blue device by molecular orientation of blue dopant

Molecular-isotopic stratigraphy of long-chain n-alkanes in Lake Baikal Holocene and glacial age sediments

37.2: Efficiency Improvement of Fluorescent Blue Device by Molecular Orientation of Blue Dopant

56.4: New Deep Blue Fluorescent Materials and Their Application to High Performance OLEDs

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