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Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease

PloS one, 2013-08, Vol.8 (8), p.e70274-e70274

2013

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The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

Trends in neurosciences (Regular ed.), 2017-06, Vol.40 (6), p.358-370

2017

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Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

Human molecular genetics, 2015-11, Vol.24 (21), p.6013-6028

2015

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Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model

PloS one, 2021-06, Vol.16 (6), p.e0252325-e0252325

2021

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Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

Neurobiology of disease, 2019-04, Vol.124 (C), p.276-288

2019

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RIT2 regulates autophagy lysosomal pathway induction and protects against α-synuclein pathology in a cellular model of Parkinson's disease

Neurobiology of disease, 2024-09, Vol.199, p.106568, Article 106568

2024

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Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase

The Journal of biological chemistry, 2014-05, Vol.289 (21), p.14569-14582

2014

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Evaluation of Strategies for Measuring Lysosomal Glucocerebrosidase Activity

Movement disorders, 2021-12, Vol.36 (12), p.2719-2730

2021

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Discovery and Preclinical Profiling of 3‑[4-(Morpholin-4-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor

Journal of medicinal chemistry, 2015-01, Vol.58 (1), p.419-432

2015

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G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons

The Journal of neuroscience, 2016-07, Vol.36 (28), p.7415-7427

2016

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Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons

PloS one, 2013-12, Vol.8 (12), p.e85815-e85815

2013

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Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson's Disease?

Frontiers in cell and developmental biology, 2021-01, Vol.8, p.608026-608026

2021

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Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration

The Journal of biological chemistry, 2015-08, Vol.290 (32), p.19433-19444

2015

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Nigrostriatal tau pathology in parkinsonism and Parkinson's disease

Brain (London, England : 1878), 2024-02, Vol.147 (2), p.444-457

2024

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DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites

The Journal of biological chemistry, 2016-01, Vol.291 (2), p.613-629

2016

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Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection

Journal of neurochemistry, 2017-08, Vol.142 (3), p.429-443

2017

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Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State

Cell chemical biology, 2018-11, Vol.25 (11), p.1389-1402.e9

2018

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Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease

NPJ Parkinson's Disease, 2021-07, Vol.7 (1), p.65-65, Article 65

2021

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Lysophosphatidylcholine acyltransferase 1 promotes pathology and toxicity in two distinct cell-based alpha-synuclein models

Neuroscience letters, 2022-02, Vol.772, p.136491-136491, Article 136491

2022

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Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif

PloS one, 2010-10, Vol.5 (10), p.e13672-e13672

2010

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An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2

Neurobiology of disease, 2019-07, Vol.127, p.512-526

2019

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Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice

Proceedings of the National Academy of Sciences - PNAS, 2021-08, Vol.118 (31), p.1

2021

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Neuronal influences are necessary to produce mitochondrial co‐localization with glutamate transporters in astrocytes

Journal of neurochemistry, 2014-09, Vol.130 (5), p.668-677

2014

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Mixed pathology as a rule, not exception: Time to reconsider disease nosology

Handbook of Clinical Neurology, 2023, Vol.192, p.57-71

2023

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The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

Frontiers in neuroscience, 2020-08, Vol.14, p.865-865

2020

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Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease

The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model

Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

RIT2 regulates autophagy lysosomal pathway induction and protects against α-synuclein pathology in a cellular model of Parkinson's disease

Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase

Evaluation of Strategies for Measuring Lysosomal Glucocerebrosidase Activity

Discovery and Preclinical Profiling of 3‑[4-(Morpholin-4-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor

G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons

Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons

Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson's Disease?

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration

Nigrostriatal tau pathology in parkinsonism and Parkinson's disease

DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites

Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection

Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State

Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease

Lysophosphatidylcholine acyltransferase 1 promotes pathology and toxicity in two distinct cell-based alpha-synuclein models

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif

An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2

Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice

Neuronal influences are necessary to produce mitochondrial co‐localization with glutamate transporters in astrocytes

Mixed pathology as a rule, not exception: Time to reconsider disease nosology

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

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