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Quantitative Structure–Activity Relationship Model for the Fetal–Maternal Blood Concentration Ratio of Chemicals in Humans

Biological and Pharmaceutical Bulletin, 2015/06/01, Vol.38(6), pp.930-934

2015

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Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse

Toxicological sciences, 2019-04, Vol.168 (2), p.572-596

2019

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Hand1-Luc Embryonic Stem Cell Test (Hand1-Luc EST): A novel rapid and highly reproducible in vitro test for embryotoxicity by measuring cytotoxicity and differentiation toxicity using engineered mouse ES cells

The Journal of Toxicological Sciences, 2015/04/01, Vol.40(2), pp.251-261

2015

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Metabolism and physiologically based pharmacokinetic modeling of flumioxazin in pregnant animals

Toxicology and applied pharmacology, 2014-06, Vol.277 (3), p.242-249

2014

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Flumioxazin metabolism in pregnant animals and cell-based protoporphyrinogen IX oxidase (PPO) inhibition assay of fetal metabolites in various animal species to elucidate the mechanism of the rat-specific developmental toxicity

Toxicology and applied pharmacology, 2018-01, Vol.339, p.34-41

2018

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Metabolism of (Z)‑(1R,3R)‑Profluthrin in Rats

Journal of agricultural and food chemistry, 2015-10, Vol.63 (39), p.8651-8661

2015

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Editor's Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes

Toxicological sciences, 2017-08, Vol.158 (2), p.412-430

2017

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Editor’s Highlight: Development of Novel Neural Embryonic Stem Cell Tests for High-Throughput Screening of Embryotoxic Chemicals

Toxicological sciences, 2017-09, Vol.159 (1), p.238-250

2017

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Mode of Action Analysis for the Synthetic Pyrethroid Metofluthrin-Induced Rat Liver Tumors: Evidence for Hepatic CYP2B Induction and Hepatocyte Proliferation

Toxicological sciences, 2009-03, Vol.108 (1), p.69-80

2009

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Identification and in silico prediction of metabolites of the model compound, tebufenozide by human CYP3A4 and CYP2C19

Bioorganic & medicinal chemistry, 2015-10, Vol.23 (20), p.6594-6601

2015

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Metabolism of Pyridalyl in Rats: Excretion, Distribution, and Biotransformation of Dichloropropenyl-Labeled Pyridalyl

Journal of agricultural and food chemistry, 2009-11, Vol.57 (22), p.10845-10851

2009

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Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes

Toxicology (Amsterdam), 2009-04, Vol.258 (1), p.64-69

2009

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Novel approach for verification of a human PBPK modeling strategy using chimeric mice in the health risk assessment of epyrifenacil

Toxicology and applied pharmacology, 2023-04, Vol.465, p.116439-116439, Article 116439

2023

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Metabolism of pyridalyl in rats

Drug metabolism and disposition, 2009-12, Vol.37 (12), p.2284

2009

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Metabolism of 2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl ether (pyridalyl) in rats after repeated oral administration and a simple physiologically based pharmacokinetic modeling in brown and white adipose tissues

Drug metabolism and disposition, 2010-05, Vol.38 (5), p.824

2010

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Prediction of the human pharmacokinetics of epyrifenacil and its major metabolite, S-3100-CA, by a physiologically based pharmacokinetic modeling using chimeric mice with humanized liver

Toxicology and applied pharmacology, 2022-03, Vol.439, p.115912-115912, Article 115912

2022

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Metabolism of Flufenpyr-ethyl in Rats and Mice

Journal of agricultural and food chemistry, 2009-06, Vol.57 (11), p.4872-4877

2009

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Combining Genomics To Identify the Pathways of Post-Transcriptional Nongenotoxic Signaling and Energy Homeostasis in Livers of Rats Treated with the Pregnane X Receptor Agonist, Pregnenolone Carbonitrile

Journal of proteome research, 2017-10, Vol.16 (10), p.3634-3645

2017

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Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver

Toxicological sciences, 2014-11, Vol.142 (1), p.137-157

2014

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Metabolism of metofluthrin in rats: I. Identification of metabolites

Xenobiotica, 2018-02, Vol.48 (2), p.157-169

2018

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Metabolism of metofluthrin in rats: II. Excretion, distribution and amount of metabolites

Xenobiotica, 2018-11, Vol.48 (11), p.1113-1127

2018

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Prediction of in vivo developmental toxicity by combination of Hand1-Luc embryonic stem cell test and metabolic stability test with clarification of metabolically inapplicable candidates

Toxicology letters, 2016-09, Vol.259, p.44-51

2016

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Identification of metabolites of propyrisulfuron in rats

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014-04, Vol.955-956, p.64-71

2014

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Metabolism of Furametpyr. 1. Identification of Metabolites and in Vitro Biotransformation in Rats and Humans

Journal of agricultural and food chemistry, 2000-11, Vol.48 (11), p.5754-5759

2000

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Metabolism of propyrisulfuron: 14C excretion, 14C concentration in plasma and tissues, and amount of metabolites in rats

Xenobiotica, 2014-10, Vol.44 (10), p.882-892

2014

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Quantitative Structure–Activity Relationship Model for the Fetal–Maternal Blood Concentration Ratio of Chemicals in Humans

Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse

Hand1-Luc Embryonic Stem Cell Test (Hand1-Luc EST): A novel rapid and highly reproducible in vitro test for embryotoxicity by measuring cytotoxicity and differentiation toxicity using engineered mouse ES cells

Metabolism and physiologically based pharmacokinetic modeling of flumioxazin in pregnant animals

Flumioxazin metabolism in pregnant animals and cell-based protoporphyrinogen IX oxidase (PPO) inhibition assay of fetal metabolites in various animal species to elucidate the mechanism of the rat-specific developmental toxicity

Metabolism of (Z)‑(1R,3R)‑Profluthrin in Rats

Editor's Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes

Editor’s Highlight: Development of Novel Neural Embryonic Stem Cell Tests for High-Throughput Screening of Embryotoxic Chemicals

Mode of Action Analysis for the Synthetic Pyrethroid Metofluthrin-Induced Rat Liver Tumors: Evidence for Hepatic CYP2B Induction and Hepatocyte Proliferation

Identification and in silico prediction of metabolites of the model compound, tebufenozide by human CYP3A4 and CYP2C19

Metabolism of Pyridalyl in Rats: Excretion, Distribution, and Biotransformation of Dichloropropenyl-Labeled Pyridalyl

Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes

Novel approach for verification of a human PBPK modeling strategy using chimeric mice in the health risk assessment of epyrifenacil

Metabolism of pyridalyl in rats

Metabolism of 2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl ether (pyridalyl) in rats after repeated oral administration and a simple physiologically based pharmacokinetic modeling in brown and white adipose tissues

Prediction of the human pharmacokinetics of epyrifenacil and its major metabolite, S-3100-CA, by a physiologically based pharmacokinetic modeling using chimeric mice with humanized liver

Metabolism of Flufenpyr-ethyl in Rats and Mice

Combining Genomics To Identify the Pathways of Post-Transcriptional Nongenotoxic Signaling and Energy Homeostasis in Livers of Rats Treated with the Pregnane X Receptor Agonist, Pregnenolone Carbonitrile

Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver

Metabolism of metofluthrin in rats: I. Identification of metabolites

Metabolism of metofluthrin in rats: II. Excretion, distribution and amount of metabolites

Prediction of in vivo developmental toxicity by combination of Hand1-Luc embryonic stem cell test and metabolic stability test with clarification of metabolically inapplicable candidates

Identification of metabolites of propyrisulfuron in rats

Metabolism of Furametpyr. 1. Identification of Metabolites and in Vitro Biotransformation in Rats and Humans

Metabolism of propyrisulfuron: 14C excretion, 14C concentration in plasma and tissues, and amount of metabolites in rats

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