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Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists

Journal of medicinal chemistry, 1998-07, Vol.41 (15), p.2709-2719

1998

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Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists

Bioorganic & medicinal chemistry letters, 1999-03, Vol.9 (5), p.647-652

1999

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LY303870, a centrally active neurokinin-1 antagonist with a long duration of action

The Journal of pharmacology and experimental therapeutics, 1997-02, Vol.280 (2), p.774

1997

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Acyl Sulfonamide Anti-Proliferatives: Benzene Substituent Structure−Activity Relationships for a Novel Class of Antitumor Agents

Journal of medicinal chemistry, 2004-10, Vol.47 (22), p.5367-5380

2004

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[3H]LY303870, a Novel Nonpeptide Radioligand for the NK‐1 Receptor

Journal of neurochemistry, 1996-03, Vol.66 (3), p.1095-1102

1996

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Structure-activity relationships of a series of benzothiophene-derived NPY Y1 antagonists: Optimization of the C-2 side chain

Bioorganic & medicinal chemistry letters, 1999-02, Vol.9 (3), p.475-480

1999

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Structure-activity relationships of a series of 1-substituted-4-methylbenzimidazole neuropeptide Y-1 receptor antagonists

Bioorganic & medicinal chemistry letters, 1998-03, Vol.8 (5), p.473-476

1998

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Potent and Selective 1,2,3-Trisubstituted Indole NPY Y-1 Antagonists

Journal of medicinal chemistry, 1997-11, Vol.40 (23), p.3712-3714

1997

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Neuropeptide Y receptor antagonists in obesity

Expert opinion on investigational drugs, 1997-12, Vol.6 (12), p.1827-1838

1997

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Characteristic Physical Properties and Structural Fragments of Marketed Oral Drugs

Journal of medicinal chemistry, 2004-01, Vol.47 (1), p.224-232

2004

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Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes

Experimental biology and medicine (Maywood, N.J.), 2003-03, Vol.228 (3), p.217-244

2003

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A novel cephalosporin dehydrothiazine ring cleavage mode

Tetrahedron letters, 1992-10, Vol.33 (42), p.6291-6294

1992

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Expedited discovery of second generation NK-1 antagonists: identification of a nonbasic aryloxy substituent

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (13), p.1643-1646

2001

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The non-peptide NK-1 receptor antagonist LY303870 inhibits neurogenic dural inflammation in guinea pigs

Life sciences (1973), 1997-03, Vol.60 (18), p.1553-1561

1997

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3-Aryl-1,2-diacetamidopropane Derivatives as Novel and Potent NK-1 Receptor Antagonists

Journal of medicinal chemistry, 1996-02, Vol.39 (3), p.736-748

1996

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Neuropeptide Y Antagonists: Clinical Promise and Recent Developments

Current pharmaceutical design, 1995-10, Vol.1 (3), p.295-304

1995

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Stress and central Urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptor

European journal of pharmacology, 2005-02, Vol.509 (2-3), p.145-153

2005

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Peripheral effects of three novel non-peptide tachykinin NK1 receptor antagonists in the anaesthetized rat

European journal of pharmacology, 1996-12, Vol.318 (2-3), p.377-385

1996

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Substance P Regulates PTH Secretion through the Neurokinin-1 Receptor

Biochemical and biophysical research communications, 2000-04, Vol.270 (1), p.230-234

2000

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Pharmacological characterization of LY303870: a novel, potent and selective nonpeptide substance P (neurokinin-1) receptor antagonist

The Journal of pharmacology and experimental therapeutics, 1995-11, Vol.275 (2), p.737

1995

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Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond

Alcohol (Fayetteville, N.Y.), 2009-11, Vol.43 (7), p.491-498

2009

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A total asymmetric synthesis of the isolactarane sesquiterpene (−)-merulidial

Tetrahedron letters, 1992-08, Vol.33 (32), p.4541-4544

1992

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NEUROPEPTIDEY (NPY) AND OBESITY: POTENT AND SELECTIVE NONPEPTIDEY1 RECEPTOR ANTAGONISTS REDUCE FOOD CONSUMPTION AND BODY WEIGHT IN RODENTS

Behavioural pharmacology, 1998-08, Vol.9 (1), p.S40-S40

1998

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NEUROPEPTIDEY (NPY) AND OBESITY: POTENT AND SELECTIVE NONPEPTIDEY1 RECEPTOR ANTAGONISTS REDUCE FOOD CONSUMPTION AND BODY WEIGHT IN RODENTS

Behavioural pharmacology, 1998-08, Vol.9 Suppl (Supplement), p.S40-S40

1998

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Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.617-620

2005

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Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists

Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists

LY303870, a centrally active neurokinin-1 antagonist with a long duration of action

Acyl Sulfonamide Anti-Proliferatives: Benzene Substituent Structure−Activity Relationships for a Novel Class of Antitumor Agents

[3H]LY303870, a Novel Nonpeptide Radioligand for the NK‐1 Receptor

Structure-activity relationships of a series of benzothiophene-derived NPY Y1 antagonists: Optimization of the C-2 side chain

Structure-activity relationships of a series of 1-substituted-4-methylbenzimidazole neuropeptide Y-1 receptor antagonists

Potent and Selective 1,2,3-Trisubstituted Indole NPY Y-1 Antagonists

Neuropeptide Y receptor antagonists in obesity

Characteristic Physical Properties and Structural Fragments of Marketed Oral Drugs

Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes

A novel cephalosporin dehydrothiazine ring cleavage mode

Expedited discovery of second generation NK-1 antagonists: identification of a nonbasic aryloxy substituent

The non-peptide NK-1 receptor antagonist LY303870 inhibits neurogenic dural inflammation in guinea pigs

3-Aryl-1,2-diacetamidopropane Derivatives as Novel and Potent NK-1 Receptor Antagonists

Neuropeptide Y Antagonists: Clinical Promise and Recent Developments

Stress and central Urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptor

Peripheral effects of three novel non-peptide tachykinin NK1 receptor antagonists in the anaesthetized rat

Substance P Regulates PTH Secretion through the Neurokinin-1 Receptor

Pharmacological characterization of LY303870: a novel, potent and selective nonpeptide substance P (neurokinin-1) receptor antagonist

Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond

A total asymmetric synthesis of the isolactarane sesquiterpene (−)-merulidial

NEUROPEPTIDEY (NPY) AND OBESITY: POTENT AND SELECTIVE NONPEPTIDEY1 RECEPTOR ANTAGONISTS REDUCE FOOD CONSUMPTION AND BODY WEIGHT IN RODENTS

NEUROPEPTIDEY (NPY) AND OBESITY: POTENT AND SELECTIVE NONPEPTIDEY1 RECEPTOR ANTAGONISTS REDUCE FOOD CONSUMPTION AND BODY WEIGHT IN RODENTS

Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives

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