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The ontogeny of drug metabolism enzymes and implications for adverse drug events

Pharmacology & therapeutics (Oxford), 2008-05, Vol.118 (2), p.250-267

Hines, Ronald N

2008

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Ontogeny of human hepatic cytochromes P450

Journal of Biochemical and Molecular Toxicology, 2007-08, Vol.21 (4), p.169-175

Hines, Ronald N.

2007

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A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing

Environmental health perspectives, 2019-01, Vol.127 (1), p.14501-14501

2019

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Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans

Toxicological sciences, 2020-01, Vol.173 (1), p.86-99

2020

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Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny

Drug metabolism and disposition, 2016-07, Vol.44 (7), p.959-966

2016

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Developmental Expression of the Cytosolic Sulfotransferases in Human Liver

Drug metabolism and disposition, 2019-06, Vol.47 (6), p.592-600

2019

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Human hepatic UGT2B15 developmental expression

Toxicological sciences, 2014-09, Vol.141 (1), p.292-299

2014

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The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes

The Journal of pharmacology and experimental therapeutics, 2002-02, Vol.300 (2), p.355

2002

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Ontogeny of plasma proteins, albumin and binding of diazepam, cyclosporine, and deltamethrin

Pediatric research, 2016-03, Vol.79 (3), p.409-415

2016

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The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms

The Journal of pharmacology and experimental therapeutics, 2002-02, Vol.300 (2), p.361

2002

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Developmental expression of the major human hepatic CYP3A enzymes

The Journal of pharmacology and experimental therapeutics, 2003-11, Vol.307 (2), p.573

2003

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Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver

Drug metabolism and disposition, 2016-07, Vol.44 (7), p.999-1004

2016

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Developmental changes in human liver CYP2D6 expression

Drug metabolism and disposition, 2008-08, Vol.36 (8), p.1587

2008

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Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards

Toxicological sciences, 2016-07, Vol.152 (1), p.230-243

2016

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Developmental expression of human hepatic CYP2C9 and CYP2C19

The Journal of pharmacology and experimental therapeutics, 2004-03, Vol.308 (3), p.965

2004

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Risk assessment in the 21st century: Roadmap and matrix

Critical reviews in toxicology, 2014-08, Vol.44 (S3), p.6-16

2014

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A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes

Chemical research in toxicology, 2019-08, Vol.32 (8), p.1707-1721

2019

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Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages

Drug metabolism and disposition, 2017-05, Vol.45 (5), p.468-475

2017

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A 21st century roadmap for human health risk assessment

Critical reviews in toxicology, 2014-08, Vol.44 (S3), p.1-5

2014

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The NFKB1 (g.-24519delATTG) Variant is Associated with Necrotizing Enterocolitis (NEC) in Premature Infants

The Journal of surgical research, 2011-07, Vol.169 (1), p.e51-e57

2011

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Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids

Toxicological sciences, 2020-08, Vol.176 (2), p.460-469

2020

Volltextzugriff (PDF)

The Impact of Scaling Factor Variability on Risk-Relevant Pharmacokinetic Outcomes in Children: A Case Study Using Bromodichloromethane (BDCM)

Toxicological sciences, 2019-02, Vol.167 (2), p.347-359

2019

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Human hepatic CYP2B6 developmental expression: The impact of age and genotype

Biochemical pharmacology, 2009-07, Vol.78 (2), p.184-190

2009

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Epirubicin glucuronidation and UGT2B7 developmental expression

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.2097

2006

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Hepatic differentiation of amniotic epithelial cells

Hepatology (Baltimore, Md.), 2011-05, Vol.53 (5), p.1719-1729

2011

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The ontogeny of drug metabolism enzymes and implications for adverse drug events

Ontogeny of human hepatic cytochromes P450

A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing

Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans

Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny

Developmental Expression of the Cytosolic Sulfotransferases in Human Liver

Human hepatic UGT2B15 developmental expression

The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes

Ontogeny of plasma proteins, albumin and binding of diazepam, cyclosporine, and deltamethrin

The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms

Developmental expression of the major human hepatic CYP3A enzymes

Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver

Developmental changes in human liver CYP2D6 expression

Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards

Developmental expression of human hepatic CYP2C9 and CYP2C19

Risk assessment in the 21st century: Roadmap and matrix

A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes

Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages

A 21st century roadmap for human health risk assessment

The NFKB1 (g.-24519delATTG) Variant is Associated with Necrotizing Enterocolitis (NEC) in Premature Infants

Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids

The Impact of Scaling Factor Variability on Risk-Relevant Pharmacokinetic Outcomes in Children: A Case Study Using Bromodichloromethane (BDCM)

Human hepatic CYP2B6 developmental expression: The impact of age and genotype

Epirubicin glucuronidation and UGT2B7 developmental expression

Hepatic differentiation of amniotic epithelial cells

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