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Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker

The Journal of pharmacology and experimental therapeutics, 2012-11, Vol.343 (2), p.342-350

2012

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(R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors

The Journal of pharmacology and experimental therapeutics, 2008-04, Vol.325 (1), p.175-182

2008

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Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives

The Journal of pharmacology and experimental therapeutics, 2004-11, Vol.311 (2), p.502-509

2004

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8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes

Journal of medicinal chemistry, 2007-12, Vol.50 (26), p.6450-6453

2007

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Sequential C–H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD‑1 Inhibitor

Journal of the American Chemical Society, 2016-11, Vol.138 (47), p.15473-15481

2016

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Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes

European journal of pharmacology, 2015-01, Vol.746, p.50-55

2015

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Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor

Bioorganic & medicinal chemistry, 2017-07, Vol.25 (14), p.3649-3657

2017

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SGLT6 - A pharmacological target for the treatment of obesity?

Adipocyte, 2018-01, Vol.7 (4), p.277-284

2018

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3,5-Dihydro-imidazo[4,5- d]pyridazin-4-ones: A class of potent DPP-4 inhibitors

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3158-3162

2008

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Synthesis of 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one and 3-alkyl-2-bromo-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one and their selective elaboration

Tetrahedron letters, 2008-03, Vol.49 (12), p.1931-1934

2008

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Profound and sustained inhibition of platelet aggregation by fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men

Circulation (New York, N.Y.), 1997-08, Vol.96 (4), p.1130-1138

1997

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The use of the p-nitrophenylethoxycarbonyl group for amino protection in cytidine and adenosine chemistry

Tetrahedron letters, 1983, Vol.24 (34), p.3583-3586

1983

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Nucleosides. Part LI The 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) and 2-(2,4-dinitrophenyl)ethoxycarbonyl (dnpeoc) groups for protection of hydroxy functions in ribonucleosides and 2′ -deoxyribonucleosides

Helvetica chimica acta, 1993-02, Vol.76 (1), p.385-401

1993

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The p-nitrophenylethyl (NPE) group : A versatile new blocking group for phosphate and aglycone protection in nucleosides and nucleotides

Tetrahedron, 1984, Vol.40 (1), p.59-72

1984

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SGLT6 - A pharmacological target for the treatment of obesity?

Adipocyte, 2018, Vol.7 (4), p.277-284

2018

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Synthesis of new modified 2′,5′-adenylate trimers carrying 3′-amino-3′-deoxyadenosine at the 2′-terminus

Bioorganic & medicinal chemistry letters, 1994-04, Vol.4 (8), p.1047-1052

1994

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Nucleotides, Part LXIII, New 2-(4-Nitrophenyl)ethyl(Npe)- and 2-(4-Nitrophenyl)ethoxycarbonyl(Npeoc)-Protected 2′-Deoxyribonucleosides and Their 3′-Phosphoramidites - Versatile Building Blocks for Oligonucleotide Synthesis

Helvetica chimica acta, 1999-12, Vol.82 (12), p.2172-2185

1999

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Antagonism of the GPIIb/IIIa Receptor with the Nonpeptidic Molecule BIBU52: Inhibition of Platelet Aggregation In Vitro and Antithrombotic Efficacy In Vivo

Journal of cardiovascular pharmacology, 1997-08, Vol.30 (2), p.261-272

1997

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DESIGN OF HIGHLY POTENT NONPEPTIDIC FIBRINOGEN RECEPTOR ANTAGONISTS

European journal of medicinal chemistry, 1995, Vol.30, p.243s-254s

1995

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Nucleotides. Part XXVII Bis[2-(p-nitrophenyl)ethyl] Phosphorochloridate, a New Versatile Phosphorylating Agent in Nucleotide Chemistry

Helvetica chimica acta, 1987-08, Vol.70 (5), p.1286-1295

1987

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A comparative cell-based high throughput screening strategy for the discovery of selective tyrosine kinase inhibitors with anticancer activity

Anti-cancer drug design, 1999-10, Vol.14 (5), p.393

1999

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Nucleotides. Part XXVIII. Chemical syntheses of the 2′-5′-cordycepin-trimer core

Helvetica chimica acta, 1987-12, Vol.70 (8), p.2028-2038

1987

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Bis-(p-nitrophenylethyl)phosphoromonochloridate, a new versatile phosphorylating agent

Tetrahedron letters, 1982, Vol.23 (46), p.4793-4796

1982

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ChemInform Abstract: 3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: A Class of Potent DPP-4 Inhibitors

ChemInform, 2008-10, Vol.39 (42), p.no-no

2008

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The p-nitrophenylethyl (NPE) group

Tetrahedron, 1984-01, Vol.40 (1), p.59-72

1984

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Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker

(R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors

Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives

8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes

Sequential C–H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD‑1 Inhibitor

Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes

Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor

SGLT6 - A pharmacological target for the treatment of obesity?

3,5-Dihydro-imidazo[4,5- d]pyridazin-4-ones: A class of potent DPP-4 inhibitors

Synthesis of 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one and 3-alkyl-2-bromo-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one and their selective elaboration

Profound and sustained inhibition of platelet aggregation by fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men

The use of the p-nitrophenylethoxycarbonyl group for amino protection in cytidine and adenosine chemistry

Nucleosides. Part LI The 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) and 2-(2,4-dinitrophenyl)ethoxycarbonyl (dnpeoc) groups for protection of hydroxy functions in ribonucleosides and 2′ -deoxyribonucleosides

The p-nitrophenylethyl (NPE) group : A versatile new blocking group for phosphate and aglycone protection in nucleosides and nucleotides

SGLT6 - A pharmacological target for the treatment of obesity?

Synthesis of new modified 2′,5′-adenylate trimers carrying 3′-amino-3′-deoxyadenosine at the 2′-terminus

Nucleotides, Part LXIII, New 2-(4-Nitrophenyl)ethyl(Npe)- and 2-(4-Nitrophenyl)ethoxycarbonyl(Npeoc)-Protected 2′-Deoxyribonucleosides and Their 3′-Phosphoramidites - Versatile Building Blocks for Oligonucleotide Synthesis

Antagonism of the GPIIb/IIIa Receptor with the Nonpeptidic Molecule BIBU52: Inhibition of Platelet Aggregation In Vitro and Antithrombotic Efficacy In Vivo

DESIGN OF HIGHLY POTENT NONPEPTIDIC FIBRINOGEN RECEPTOR ANTAGONISTS

Nucleotides. Part XXVII Bis[2-(p-nitrophenyl)ethyl] Phosphorochloridate, a New Versatile Phosphorylating Agent in Nucleotide Chemistry

A comparative cell-based high throughput screening strategy for the discovery of selective tyrosine kinase inhibitors with anticancer activity

Nucleotides. Part XXVIII. Chemical syntheses of the 2′-5′-cordycepin-trimer core

Bis-(p-nitrophenylethyl)phosphoromonochloridate, a new versatile phosphorylating agent

ChemInform Abstract: 3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: A Class of Potent DPP-4 Inhibitors

The p-nitrophenylethyl (NPE) group

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