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Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions

Nucleic acids research, 2022-08, Vol.50 (14), p.7842-7855

2022

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Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase

Nature communications, 2021-02, Vol.12 (1), p.896-896, Article 896

2021

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Reversing Post-Infectious Epigenetic-Mediated Immune Suppression

Frontiers in immunology, 2021-06, Vol.12, p.688132-688132

2021

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mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (7), p.2235-2246

2013

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Engineering the next generation of cell-based therapeutics

Nature reviews. Drug discovery, 2022-09, Vol.21 (9), p.655-675

2022

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Editing the epigenome: technologies for programmable transcription and epigenetic modulation

Nature methods, 2016-02, Vol.13 (2), p.127-137

2016

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CRISPR/Cas-Based Epigenome Editing: Advances, Applications, and Clinical Utility

Trends in biotechnology (Regular ed.), 2021-07, Vol.39 (7), p.678-691

2021

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Engineering the next generation of cell-based therapeutics

Nature reviews. Drug discovery, 2022-05, Vol.21 (9), p.655-675

2022

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The Open Chromatin Landscape of Kaposi's Sarcoma-Associated Herpesvirus

Journal of Virology, 2013-11, Vol.87 (21), p.11831-11842

2013

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Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas

Journal of Virology, 2010-04, Vol.84 (8), p.3898-3908

2010

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Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector

Nucleic acids research, 2014-10, Vol.42 (19), p.e147-e147

2014

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Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

Nature biotechnology, 2015-05, Vol.33 (5), p.510-517

2015

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Enabling functional genomics with genome engineering

Genome research, 2015-10, Vol.25 (10), p.1442-1455

2015

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Persistent tailoring of MSC activation through genetic priming

Molecular therapy. Methods & clinical development, 2024-09, Vol.32 (3), p.101316, Article 101316

2024

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CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Nature biotechnology, 2017-06, Vol.35 (6), p.561-568

2017

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Tuning neurodegeneration-linked gene expression, one (edited) base at a time

Molecular therapy, 2022-12, Vol.30 (12), p.3512-3514

2022

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Quantitative Analysis of the Bidirectional Viral G-Protein-Coupled Receptor and Lytic Latency-Associated Nuclear Antigen Promoter of Kaposi's Sarcoma-Associated Herpesvirus

Journal of Virology, 2012-09, Vol.86 (18), p.9683-9695

2012

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Harnessing CRISPR-Cas9 for Epigenetic Engineering

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2518, p.237

2022

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Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells

ACS synthetic biology, 2022-10, Vol.11 (10), p.3239-3250

2022

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Multiplex Base-Editing Enables Combinatorial Epigenetic Regulation for Genome Mining of Fungal Natural Products

Journal of the American Chemical Society, 2023-01, Vol.145 (1), p.413-421

2023

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Transgenic mice for in vivo epigenome editing with CRISPR-based systems

Nature methods, 2021-08, Vol.18 (8), p.965-974

2021

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Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control

Nature methods, 2023-11, Vol.20 (11), p.1716-1728

2023

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Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects

Science advances, 2020-07, Vol.6 (29), p.eaba1773-eaba1773

2020

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The sound of silence: Transgene silencing in mammalian cell engineering

Cell systems, 2022-12, Vol.13 (12), p.950-973

2022

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Combining compact human protein domains with CRISPR systems for robust gene activation

Nature methods, 2023-11, Vol.20 (11), p.1635-1636

2023

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Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions

Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase

Reversing Post-Infectious Epigenetic-Mediated Immune Suppression

mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis

Engineering the next generation of cell-based therapeutics

Editing the epigenome: technologies for programmable transcription and epigenetic modulation

CRISPR/Cas-Based Epigenome Editing: Advances, Applications, and Clinical Utility

Engineering the next generation of cell-based therapeutics

The Open Chromatin Landscape of Kaposi's Sarcoma-Associated Herpesvirus

Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas

Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

Enabling functional genomics with genome engineering

Persistent tailoring of MSC activation through genetic priming

CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Tuning neurodegeneration-linked gene expression, one (edited) base at a time

Quantitative Analysis of the Bidirectional Viral G-Protein-Coupled Receptor and Lytic Latency-Associated Nuclear Antigen Promoter of Kaposi's Sarcoma-Associated Herpesvirus

Harnessing CRISPR-Cas9 for Epigenetic Engineering

Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells

Multiplex Base-Editing Enables Combinatorial Epigenetic Regulation for Genome Mining of Fungal Natural Products

Transgenic mice for in vivo epigenome editing with CRISPR-based systems

Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control

Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects

The sound of silence: Transgene silencing in mammalian cell engineering

Combining compact human protein domains with CRISPR systems for robust gene activation

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