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Engineering the next generation of cell-based therapeutics

Nature reviews. Drug discovery, 2022-09, Vol.21 (9), p.655-675

2022

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CRISPR/Cas-Based Epigenome Editing: Advances, Applications, and Clinical Utility

Trends in biotechnology (Regular ed.), 2021-07, Vol.39 (7), p.678-691

2021

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Editing the epigenome: technologies for programmable transcription and epigenetic modulation

Nature methods, 2016-02, Vol.13 (2), p.127-137

2016

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Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions

Nucleic acids research, 2022-08, Vol.50 (14), p.7842-7855

2022

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Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector

Nucleic acids research, 2014-10, Vol.42 (19), p.e147-e147

2014

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Enabling functional genomics with genome engineering

Genome research, 2015-10, Vol.25 (10), p.1442-1455

2015

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Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase

Nature communications, 2021-02, Vol.12 (1), p.896-896, Article 896

2021

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Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

Nature biotechnology, 2015-05, Vol.33 (5), p.510-517

2015

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CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Nature biotechnology, 2017-06, Vol.35 (6), p.561-568

2017

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Tuning neurodegeneration-linked gene expression, one (edited) base at a time

Molecular therapy, 2022-12, Vol.30 (12), p.3512-3514

2022

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Harnessing CRISPR-Cas9 for Epigenetic Engineering

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2518, p.237

2022

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Engineering the next generation of cell-based therapeutics

Nature reviews. Drug discovery, 2022-05, Vol.21 (9), p.655-675

2022

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Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells

ACS synthetic biology, 2022-10, Vol.11 (10), p.3239-3250

2022

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Transgenic mice for in vivo epigenome editing with CRISPR-based systems

Nature methods, 2021-08, Vol.18 (8), p.965-974

2021

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Multiplex Base-Editing Enables Combinatorial Epigenetic Regulation for Genome Mining of Fungal Natural Products

Journal of the American Chemical Society, 2023-01, Vol.145 (1), p.413-421

2023

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Reversing Post-Infectious Epigenetic-Mediated Immune Suppression

Frontiers in immunology, 2021-06, Vol.12, p.688132-688132

2021

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mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (7), p.2235-2246

2013

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Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control

Nature methods, 2023-11, Vol.20 (11), p.1716-1728

2023

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Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects

Science advances, 2020-07, Vol.6 (29), p.eaba1773-eaba1773

2020

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The Open Chromatin Landscape of Kaposi's Sarcoma-Associated Herpesvirus

Journal of Virology, 2013-11, Vol.87 (21), p.11831-11842

2013

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Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas

Journal of Virology, 2010-04, Vol.84 (8), p.3898-3908

2010

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The sound of silence: Transgene silencing in mammalian cell engineering

Cell systems, 2022-12, Vol.13 (12), p.950-973

2022

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Persistent tailoring of MSC activation through genetic priming

Molecular therapy. Methods & clinical development, 2024-09, Vol.32 (3), p.101316, Article 101316

2024

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Quantitative Analysis of the Bidirectional Viral G-Protein-Coupled Receptor and Lytic Latency-Associated Nuclear Antigen Promoter of Kaposi's Sarcoma-Associated Herpesvirus

Journal of Virology, 2012-09, Vol.86 (18), p.9683-9695

2012

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Combining compact human protein domains with CRISPR systems for robust gene activation

Nature methods, 2023-11, Vol.20 (11), p.1635-1636

2023

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Engineering the next generation of cell-based therapeutics

CRISPR/Cas-Based Epigenome Editing: Advances, Applications, and Clinical Utility

Editing the epigenome: technologies for programmable transcription and epigenetic modulation

Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions

Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector

Enabling functional genomics with genome engineering

Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Tuning neurodegeneration-linked gene expression, one (edited) base at a time

Harnessing CRISPR-Cas9 for Epigenetic Engineering

Engineering the next generation of cell-based therapeutics

Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells

Transgenic mice for in vivo epigenome editing with CRISPR-based systems

Multiplex Base-Editing Enables Combinatorial Epigenetic Regulation for Genome Mining of Fungal Natural Products

Reversing Post-Infectious Epigenetic-Mediated Immune Suppression

mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis

Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control

Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects

The Open Chromatin Landscape of Kaposi's Sarcoma-Associated Herpesvirus

Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas

The sound of silence: Transgene silencing in mammalian cell engineering

Persistent tailoring of MSC activation through genetic priming

Quantitative Analysis of the Bidirectional Viral G-Protein-Coupled Receptor and Lytic Latency-Associated Nuclear Antigen Promoter of Kaposi's Sarcoma-Associated Herpesvirus

Combining compact human protein domains with CRISPR systems for robust gene activation

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