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Functional classification and validation of yeast prenylation motifs using machine learning and genetic reporters

PloS one, 2022-06, Vol.17 (6), p.e0270128-e0270128

2022

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Evaluating protein prenylation of human and viral CaaX sequences using a humanized yeast system

Disease models & mechanisms, 2024-05, Vol.17 (5)

2024

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MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase

International journal of molecular sciences, 2021-11, Vol.22 (21), p.12042

2021

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Library Screening, In Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences as Substrates for Protein Farnesyltransferase

International journal of molecular sciences, 2024-05, Vol.25 (10), p.5324

2024

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Protein Farnesyltransferase Catalyzes Unanticipated Farnesylation and Geranylgeranylation of Shortened Target Sequences

Biochemistry (Easton), 2020-03, Vol.59 (11), p.1149-1162

2020

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8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells

Bioorganic & medicinal chemistry, 2016-01, Vol.24 (2), p.160-178

2016

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Comprehensive analysis of CXXX sequence space reveals that Saccharomyces cerevisiae GGTase-I mainly relies on a2X substrate determinants

G3 : genes - genomes - genetics, 2024-08, Vol.14 (8)

2024

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Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome

The Journal of biological chemistry, 2018-02, Vol.293 (8), p.2770-2785

2018

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A comprehensive in vivo screen of yeast farnesyltransferase activity reveals broad reactivity across a majority of CXXX sequences

G3 : genes - genomes - genetics, 2023-07, Vol.13 (7)

2023

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Mice lacking ASIC2 and βENaC are protected from high-fat-diet-induced metabolic syndrome

Frontiers in endocrinology (Lausanne), 2024-08, Vol.15, p.1449344

2024

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Ste24p Mediates Proteolysis of Both Isoprenylated and Non-prenylated Oligopeptides

The Journal of biological chemistry, 2016-07, Vol.291 (27), p.14185-14198

2016

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A shunt pathway limits the CaaX processing of Hsp40 Ydj1p and regulates Ydj1p-dependent phenotypes

eLife, 2016-08, Vol.5

2016

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Targeted genetic and small molecule disruption of N-Ras CaaX cleavage alters its localization and oncogenic potential

Bioorganic chemistry, 2024-06, Vol.147, p.107316-107316, Article 107316

2024

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Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function

Microbiology spectrum, 2023-02, Vol.11 (1), p.e0269222-e0269222

2023

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Protein Isoprenylation in Yeast Targets COOH-Terminal Sequences Not Adhering to the CaaX Consensus

Genetics (Austin), 2018-12, Vol.210 (4), p.1301-1316

2018

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Bone marrow monocytes and macrophages from mice lacking βENaC and ASIC2 have a reduced chemotactic migration response and polarization

Physiological reports, 2024-07, Vol.12 (14), p.e16139-n/a

2024

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Topology of the Yeast Ras Converting Enzyme As Inferred from Cysteine Accessibility Studies

Biochemistry (Easton), 2013-09, Vol.52 (38), p.6601-6614

2013

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Homotetrameric Form of Cin8p, a Saccharomyces cerevisiae Kinesin-5 Motor, Is Essential for Its in Vivo Function

The Journal of biological chemistry, 2006-09, Vol.281 (36), p.26004-26013

2006

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Small-Molecule Inhibitors of the Rce1p CaaX Protease

Journal of biomolecular screening, 2007-10, Vol.12 (7), p.983-993

2007

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Mutational Analysis of the Ras Converting Enzyme Reveals a Requirement for Glutamate and Histidine Residues

The Journal of biological chemistry, 2006-02, Vol.281 (8), p.4596-4605

2006

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Mitotic motors in Saccharomyces cerevisiae

BBA - Molecular Cell Research, 2000-03, Vol.1496 (1), p.99-116

2000

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Freshly isolated bone marrow monocytes from mice lacking βENaC or ASIC2 have sex-linked reduced chemotactic migration responses

Physiology (Bethesda, Md.), 2024-05, Vol.39 (S1)

2024

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Chemical inhibition of CaaX protease activity disrupts yeast Ras localization

Yeast (Chichester, England), 2010-06, Vol.27 (6), p.327-343

2010

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Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones

Biochimica et biophysica acta, 2007-06, Vol.1773 (6), p.853-862

2007

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Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases

Bioorganic & medicinal chemistry, 2010-09, Vol.18 (17), p.6230-6237

2010

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Functional classification and validation of yeast prenylation motifs using machine learning and genetic reporters

Evaluating protein prenylation of human and viral CaaX sequences using a humanized yeast system

MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase

Library Screening, In Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences as Substrates for Protein Farnesyltransferase

Protein Farnesyltransferase Catalyzes Unanticipated Farnesylation and Geranylgeranylation of Shortened Target Sequences

8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells

Comprehensive analysis of CXXX sequence space reveals that Saccharomyces cerevisiae GGTase-I mainly relies on a2X substrate determinants

Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome

A comprehensive in vivo screen of yeast farnesyltransferase activity reveals broad reactivity across a majority of CXXX sequences

Mice lacking ASIC2 and βENaC are protected from high-fat-diet-induced metabolic syndrome

Ste24p Mediates Proteolysis of Both Isoprenylated and Non-prenylated Oligopeptides

A shunt pathway limits the CaaX processing of Hsp40 Ydj1p and regulates Ydj1p-dependent phenotypes

Targeted genetic and small molecule disruption of N-Ras CaaX cleavage alters its localization and oncogenic potential

Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function

Protein Isoprenylation in Yeast Targets COOH-Terminal Sequences Not Adhering to the CaaX Consensus

Bone marrow monocytes and macrophages from mice lacking βENaC and ASIC2 have a reduced chemotactic migration response and polarization

Topology of the Yeast Ras Converting Enzyme As Inferred from Cysteine Accessibility Studies

Homotetrameric Form of Cin8p, a Saccharomyces cerevisiae Kinesin-5 Motor, Is Essential for Its in Vivo Function

Small-Molecule Inhibitors of the Rce1p CaaX Protease

Mutational Analysis of the Ras Converting Enzyme Reveals a Requirement for Glutamate and Histidine Residues

Mitotic motors in Saccharomyces cerevisiae

Freshly isolated bone marrow monocytes from mice lacking βENaC or ASIC2 have sex-linked reduced chemotactic migration responses

Chemical inhibition of CaaX protease activity disrupts yeast Ras localization

Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones

Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases

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