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TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis

Cell and tissue research, 2012, Vol.347 (1), p.117-128

2012

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Downstream Targets of VHL/HIF-α Signaling in Renal Clear Cell Carcinoma Progression: Mechanisms and Therapeutic Relevance

Cancers, 2023-02, Vol.15 (4), p.1316

2023

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Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

Nature cell biology, 2006-08, Vol.8 (8), p.877-884

2006

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PAI‐1 induction during kidney injury promotes fibrotic epithelial dysfunction via deregulation of klotho, p53, and TGF‐β1‐receptor signaling

The FASEB journal, 2021-07, Vol.35 (7), p.e21725-n/a

2021

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The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1

Biomolecules (Basel, Switzerland), 2019-08, Vol.9 (8), p.341

2019

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Cancer-Associated Fibroblasts: Mechanisms of Tumor Progression and Novel Therapeutic Targets

Cancers, 2022-02, Vol.14 (5), p.1231

2022

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Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype

The FASEB journal, 2018-05, Vol.32 (5), p.2644-2657

2018

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Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression

Cancers, 2018-05, Vol.10 (6), p.159

2018

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Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression

PloS one, 2011, Vol.6 (7), p.e22896-e22896

2011

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Editorial: Premature Aging and Senescence in Renal Fibrosis

Frontiers in pharmacology, 2021-07, Vol.12, p.734892-734892

2021

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Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species

Cellular signalling, 2013-11, Vol.25 (11), p.2198-2209

2013

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Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity

Cellular signalling, 2014-07, Vol.26 (7), p.1427-1436

2014

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SERPINE1: Role in Cholangiocarcinoma Progression and a Therapeutic Target in the Desmoplastic Microenvironment

Cells (Basel, Switzerland), 2024-05, Vol.13 (10), p.796

2024

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AQP2: Mutations Associated with Congenital Nephrogenic Diabetes Insipidus and Regulation by Post-Translational Modifications and Protein-Protein Interactions

Cells (Basel, Switzerland), 2020-10, Vol.9 (10), p.2172

2020

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PAI-1: An Integrator of Cell Signaling and Migration

International Journal of Cell Biology, 2011, Vol.2011, p.562481-9

2011

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TGF-β1/p53 signaling in renal fibrogenesis

Cellular signalling, 2018-03, Vol.43, p.1-10

2018

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TGF-β signaling in tissue fibrosis: Redox controls, target genes and therapeutic opportunities

Cellular signalling, 2013-01, Vol.25 (1), p.264-268

2013

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Linking cell structure to gene regulation: Signaling events and expression controls on the model genes PAI-1 and CTGF

Cellular signalling, 2010-10, Vol.22 (10), p.1413-1419

2010

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Heat Shock Protein 27, a Novel Downstream Target of Collagen Type XI alpha 1, Synergizes with Fatty Acid Oxidation to Confer Cisplatin Resistance in Ovarian Cancer Cells

Cancers, 2021-09, Vol.13 (19), p.4855

2021

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PAI-1 Mediates the TGF-β1+EGF-Induced “Scatter” Response in Transformed Human Keratinocytes

Journal of investigative dermatology, 2010-09, Vol.130 (9), p.2179-2190

2010

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SERPINE1 expression discriminates site-specific metastasis in human melanoma

Experimental dermatology, 2012-07, Vol.21 (7), p.551-554

2012

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Differential requirement for MEK/ERK and SMAD signaling in PAI-1 and CTGF expression in response to microtubule disruption

Cellular signalling, 2009-06, Vol.21 (6), p.986-995

2009

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Drugging the undruggable: Transcription therapy for cancer

Biochimica et biophysica acta, 2013-01, Vol.1835 (1), p.76-85

2013

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The Genomic Response to TGF-β1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney

Frontiers in cell and developmental biology, 2021-07, Vol.9, p.678524-678524

2021

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Editorial: The Role of Steroid Hormones and Growth Factors in Cancer

Frontiers in cell and developmental biology, 2022-04, Vol.10, p.887529-887529

2022

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TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis

Downstream Targets of VHL/HIF-α Signaling in Renal Clear Cell Carcinoma Progression: Mechanisms and Therapeutic Relevance

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

PAI‐1 induction during kidney injury promotes fibrotic epithelial dysfunction via deregulation of klotho, p53, and TGF‐β1‐receptor signaling

The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1

Cancer-Associated Fibroblasts: Mechanisms of Tumor Progression and Novel Therapeutic Targets

Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype

Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression

Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression

Editorial: Premature Aging and Senescence in Renal Fibrosis

Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species

Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity

SERPINE1: Role in Cholangiocarcinoma Progression and a Therapeutic Target in the Desmoplastic Microenvironment

AQP2: Mutations Associated with Congenital Nephrogenic Diabetes Insipidus and Regulation by Post-Translational Modifications and Protein-Protein Interactions

PAI-1: An Integrator of Cell Signaling and Migration

TGF-β1/p53 signaling in renal fibrogenesis

TGF-β signaling in tissue fibrosis: Redox controls, target genes and therapeutic opportunities

Linking cell structure to gene regulation: Signaling events and expression controls on the model genes PAI-1 and CTGF

Heat Shock Protein 27, a Novel Downstream Target of Collagen Type XI alpha 1, Synergizes with Fatty Acid Oxidation to Confer Cisplatin Resistance in Ovarian Cancer Cells

PAI-1 Mediates the TGF-β1+EGF-Induced “Scatter” Response in Transformed Human Keratinocytes

SERPINE1 expression discriminates site-specific metastasis in human melanoma

Differential requirement for MEK/ERK and SMAD signaling in PAI-1 and CTGF expression in response to microtubule disruption

Drugging the undruggable: Transcription therapy for cancer

The Genomic Response to TGF-β1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney

Editorial: The Role of Steroid Hormones and Growth Factors in Cancer

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