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Type IIA topoisomerase inhibition by a new class of antibacterial agents

Nature (London), 2010-08, Vol.466 (7309), p.935-940

2010

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Discovery and Biochemical Characterization of Plasmodium Thioredoxin Reductase Inhibitors from an Antimalarial Set

Biochemistry (Easton), 2012-06, Vol.51 (23), p.4764-4771

2012

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The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase

Bioorganic & medicinal chemistry letters, 2002-11, Vol.12 (21), p.3171-3174

2002

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High-yield production and characterization of biologically active GST-tagged human topoisomerase IIα protein in insect cells for the development of a high-throughput assay

Protein expression and purification, 2011-04, Vol.76 (2), p.165-172

2011

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Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens

Journal of medicinal chemistry, 2002-05, Vol.45 (10), p.1959-1962

2002

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Development of an insect-cell-based assay for detection of kinase inhibition using NF-κB-inducing kinase as a paradigm

Biochemical journal, 2009-04, Vol.419 (1), p.65-73

2009

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Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin

Nature communications, 2015-12, Vol.6 (1), p.10048-10048, Article 10048

2015

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Effects of complement inhibition with soluble complement receptor-1 on vascular injury and inflammation during renal allograft rejection in the rat

The American journal of pathology, 1996-12, Vol.149 (6), p.2055-2066

1996

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Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (9), p.2305-2309

2005

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Effects of inhibition of complement activation using recombinant soluble complement receptor 1 on neutrophil CD11b/CD18 and l-selectin expression and release of interleukin-8 and elastase in simulated cardiopulmonary bypass

The Journal of thoracic and cardiovascular surgery, 1996-02, Vol.111 (2), p.451-459

1996

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Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide

Acta crystallographica. Section F, Structural biology communications, 2015-10, Vol.71 (10), p.1242-1246

2015

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Crystal structure of Staphylococcus aureus tyrosyl‐tRNA synthetase in complex with a class of potent and specific inhibitors

Protein science, 2001-10, Vol.10 (10), p.2008-2016

2001

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Lead discovery for microsomal prostaglandin E synthase using a combination of high-throughput fluorescent-based assays and RapidFire mass spectrometry

Journal of biomolecular screening, 2012-06, Vol.17 (5), p.641-650

2012

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Nanomolar Inhibitors of Staphylococcus a ureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens

Journal of medicinal chemistry, 2002-05, Vol.45 (10), p.1959-1962

2002

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Cooperative Structural Dynamics and a Novel Fidelity Mechanism in Histidyl-tRNA Synthetases

Biochemistry (Easton), 1999-09, Vol.38 (38), p.12296-12304

1999

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Structural studies on bacterial type IIA topoisomerases - targets for quinolone and coumarin antibiotics

Acta crystallographica. Section A, Foundations of crystallography, 2009-08, Vol.65 (a1), p.s25-s25

2009

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Design and synthesis of conformationally restricted eight-Membered ring diketones as potential serine protease inhibitors

Bioorganic & medicinal chemistry letters, 2002-09, Vol.12 (17), p.2359-2362

2002

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Development of an insect-cell-based assay for detection of kinase inhibition using NF-kappaB-inducing kinase as a paradigm

Biochemical journal, 2009-04, Vol.419 (1), p.65-73

2009

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Reduction of myocardial reperfusion injury with human soluble complement receptor type 1 (BRL 55730)

European journal of pharmacology, 1993-06, Vol.236 (3), p.477-481

1993

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Identification, Cloning, and Expression of a Functional Phenylalanyl-tRNA Synthetase (pheRS) from Staphylococcus aureus

Protein expression and purification, 2001-04, Vol.21 (3), p.470-484

2001

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Analysis of Activated Components of the Complement System using Optical Biosensor Techniques

Journal of molecular recognition, 1996, Vol.9 (56), p.746-746

1996

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Activation of complement by DMSO and ethanol and its inhibition by soluble complement receptor type 1

Biochemical Society transactions, 1995-05, Vol.23 (2), p.167S-167S

1995

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Analysis of activated components of the complement system using optical biosensor techniques

Journal of molecular recognition, 1996-10, Vol.9 (5-6), p.746-746

1996

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Design and Synthesis of Conformationally Restricted Eight-Membered Ring Diketones as Potential Serine Protease Inhibitors

ChemInform, 2002-12, Vol.33 (51), p.208-208

2002

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Is postnatal acetaminophen therapy problematic for preterm infants?

Pediatric research, 2024-07, Vol.96 (2), p.289-290

2024

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Type IIA topoisomerase inhibition by a new class of antibacterial agents

Discovery and Biochemical Characterization of Plasmodium Thioredoxin Reductase Inhibitors from an Antimalarial Set

The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase

High-yield production and characterization of biologically active GST-tagged human topoisomerase IIα protein in insect cells for the development of a high-throughput assay

Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens

Development of an insect-cell-based assay for detection of kinase inhibition using NF-κB-inducing kinase as a paradigm

Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin

Effects of complement inhibition with soluble complement receptor-1 on vascular injury and inflammation during renal allograft rejection in the rat

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase

Effects of inhibition of complement activation using recombinant soluble complement receptor 1 on neutrophil CD11b/CD18 and l-selectin expression and release of interleukin-8 and elastase in simulated cardiopulmonary bypass

Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide

Crystal structure of Staphylococcus aureus tyrosyl‐tRNA synthetase in complex with a class of potent and specific inhibitors

Lead discovery for microsomal prostaglandin E synthase using a combination of high-throughput fluorescent-based assays and RapidFire mass spectrometry

Nanomolar Inhibitors of Staphylococcus a ureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens

Cooperative Structural Dynamics and a Novel Fidelity Mechanism in Histidyl-tRNA Synthetases

Structural studies on bacterial type IIA topoisomerases - targets for quinolone and coumarin antibiotics

Design and synthesis of conformationally restricted eight-Membered ring diketones as potential serine protease inhibitors

Development of an insect-cell-based assay for detection of kinase inhibition using NF-kappaB-inducing kinase as a paradigm

Reduction of myocardial reperfusion injury with human soluble complement receptor type 1 (BRL 55730)

Identification, Cloning, and Expression of a Functional Phenylalanyl-tRNA Synthetase (pheRS) from Staphylococcus aureus

Analysis of Activated Components of the Complement System using Optical Biosensor Techniques

Activation of complement by DMSO and ethanol and its inhibition by soluble complement receptor type 1

Analysis of activated components of the complement system using optical biosensor techniques

Design and Synthesis of Conformationally Restricted Eight-Membered Ring Diketones as Potential Serine Protease Inhibitors

Is postnatal acetaminophen therapy problematic for preterm infants?

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