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Micropatterned primary hepatocyte co-culture (HEPATOPAC) for fatty liver disease modeling and drug screening

Scientific reports, 2023-09, Vol.13 (1), p.15837-15837, Article 15837

2023

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Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human

Molecular pharmaceutics, 2020-11, Vol.17 (11), p.4114-4124

2020

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A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation

Drug metabolism and disposition, 2019-04, Vol.47 (4), p.350-357

2019

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3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration

Clinical and translational science, 2021-09, Vol.14 (5), p.1659-1680

2021

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Targeted LC-MS/MS Proteomics-Based Strategy To Characterize in Vitro Models Used in Drug Metabolism and Transport Studies

Analytical chemistry (Washington), 2018-10, Vol.90 (20), p.11873-11882

2018

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Effects of incubation buffer conditions on in vitro primary cryopreserved hepatocyte phase I AND phase II metabolism

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S78-S78

2018

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Transcriptional Regulation of CYP2B6 Expression by Hepatocyte Nuclear Factor 3β in Human Liver Cells

PloS one, 2016-03, Vol.11 (3), p.e0150587-e0150587

2016

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P35 - The use of primary cryopreserved human hepatocytes as a model for non-alcoholic fatty liver disease (NAFLD) related changes in phase I and phase II enzyme activities

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S31-S32

2020

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Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation

International journal of molecular sciences, 2022-10, Vol.23 (20), p.12433

2022

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Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling

Molecular pharmacology, 2014-02, Vol.85 (2), p.249-260

2014

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Aldehyde oxidase activity in donor-matched fresh and cryopreserved human hepatocytes and assessment of variability in 75 donors

Drug metabolism and disposition, 2014-06, Vol.42 (6), p.1090

2014

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Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor

Scientific reports, 2015-05, Vol.5 (1), p.10405-10405, Article 10405

2015

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Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes

Cells (Basel, Switzerland), 2021-12, Vol.10 (12), p.3381

2021

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Dexamethasone mitigates remdesivir-induced liver toxicity in human primary hepatocytes and COVID-19 patients

Hepatology communications, 2023-03, Vol.7 (3), p.e0034-e0034

2023

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A10 - Characterization of differential tissue abundance of major non-cyp enzymes in human

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S21-S21

2020

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Intestinal Metabolism of Diclofenac by Polymorphic UGT2B17 Correlates with its Highly Variable Pharmacokinetics and Safety across Populations

Clinical pharmacology and therapeutics, 2023-07, Vol.114 (1), p.161-172

2023

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Targeting CAR and Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment

JCI insight, 2022-06, Vol.7 (12)

2022

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Does plasma membrane and total transporter abundance differ between suspended, plated, sandwich culture hepatocytes and human liver tissue?

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S17-S17

2019

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Can transporter-expressing cells predict rosuvastatin uptake clearance in suspended or plated human hepatocytes?

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S22-S23

2019

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55484 Dual activation of CAR and Nrf2 improves the efficacy: toxicity ratio of cyclophosphamide and doxorubicin-based treatment of TNBC

Journal of clinical and translational science, 2021-03, Vol.5 (s1), p.98-98

2021

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Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation

Drug metabolism and disposition, 2021-08, Vol.49 (8), p.683-693

2021

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Contribution of Extrahepatic Aldehyde Oxidase Activity to Human Clearance

Drug metabolism and disposition, 2021-09, Vol.49 (9), p.743-749

2021

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Phenobarbital induces SLC13A5 expression through activation of PXR but not CAR in human primary hepatocytes

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library

Toxicological sciences, 2019-01, Vol.167 (1), p.282-292

2019

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Impact of donor diversity on phase I and phase II activities in cryopreserved human hepatocytes and human liver microsomes

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100838, Article 100838

2024

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Micropatterned primary hepatocyte co-culture (HEPATOPAC) for fatty liver disease modeling and drug screening

Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human

A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation

3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration

Targeted LC-MS/MS Proteomics-Based Strategy To Characterize in Vitro Models Used in Drug Metabolism and Transport Studies

Effects of incubation buffer conditions on in vitro primary cryopreserved hepatocyte phase I AND phase II metabolism

Transcriptional Regulation of CYP2B6 Expression by Hepatocyte Nuclear Factor 3β in Human Liver Cells

P35 - The use of primary cryopreserved human hepatocytes as a model for non-alcoholic fatty liver disease (NAFLD) related changes in phase I and phase II enzyme activities

Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation

Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling

Aldehyde oxidase activity in donor-matched fresh and cryopreserved human hepatocytes and assessment of variability in 75 donors

Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor

Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes

Dexamethasone mitigates remdesivir-induced liver toxicity in human primary hepatocytes and COVID-19 patients

A10 - Characterization of differential tissue abundance of major non-cyp enzymes in human

Intestinal Metabolism of Diclofenac by Polymorphic UGT2B17 Correlates with its Highly Variable Pharmacokinetics and Safety across Populations

Targeting CAR and Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment

Does plasma membrane and total transporter abundance differ between suspended, plated, sandwich culture hepatocytes and human liver tissue?

Can transporter-expressing cells predict rosuvastatin uptake clearance in suspended or plated human hepatocytes?

55484 Dual activation of CAR and Nrf2 improves the efficacy: toxicity ratio of cyclophosphamide and doxorubicin-based treatment of TNBC

Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation

Contribution of Extrahepatic Aldehyde Oxidase Activity to Human Clearance

Phenobarbital induces SLC13A5 expression through activation of PXR but not CAR in human primary hepatocytes

Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library

Impact of donor diversity on phase I and phase II activities in cryopreserved human hepatocytes and human liver microsomes

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