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Interleukin-6 Facilitates Lipopolysaccharide-Induced Disruption in Working Memory and Expression of Other Proinflammatory Cytokines in Hippocampal Neuronal Cell Layers

The Journal of neuroscience, 2006-10, Vol.26 (42), p.10709-10716

2006

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Mechanistic investigation of imatinib-induced cardiac toxicity and the involvement of c-Abl kinase

Toxicological sciences, 2012-09, Vol.129 (1), p.188-199

2012

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Characterization, Biomarkers, and Reversibility of a Monoclonal Antibody-induced Immune Complex Disease in Cynomolgus Monkeys (Macaca fascicularis)

Toxicologic pathology, 2014-06, Vol.42 (4), p.765-773

2014

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Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma

Cancer research (Chicago, Ill.), 2022-07, Vol.82 (14), p.2610-2624

2022

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Structural, functional, and molecular characterization of the SHHF model of heart failure

American journal of physiology. Heart and circulatory physiology, 2002-11, Vol.283 (5), p.H1775-H1784

2002

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Pan-FGFR inhibition leads to blockade of FGF23 signaling, soft tissue mineralization, and cardiovascular dysfunction

Toxicological sciences, 2013-10, Vol.135 (2), p.451-464

2013

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Cardiovascular differentiation of imatinib and bosutinib in the rat

International journal of hematology, 2013-11, Vol.98 (5), p.597-607

2013

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Cardiovascular Effects in Rats following Exposure to a Receptor Tyrosine Kinase Inhibitor

Toxicologic pathology, 2010-04, Vol.38 (3), p.416-428

2010

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Time course of AQP-2 and ENaC regulation in the kidney in response to PPAR agonists associated with marked edema in rats

Pharmacological research, 2008-05, Vol.57 (5), p.383-392

2008

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Assessment of a novel in vitro assay for early detection of effects on heart rate

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e16-e17

2011

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Surgical method development and refinement of the blood pressure add-on component in dogs selected for jacketed external telemetry

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e40-e41

2011

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Ex-vivo investigation of aldosterone-induced endothelial dysfunction in the Rat

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e31-e32

2011

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Validation of combined toxicology and cardiovascular safety pharmacology studies using JET technology

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e41-e42

2011

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Structural, functional, and molecular characterization of the SHHF model of heart failure

American journal of physiology. Heart and circulatory physiology, 2002-11, Vol.52 (5), p.H1775-H1784

2002

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Health and environmental sciences institute integrated strategies working group: Update on the evaluation of drug-induced changes in the cardiac inotropy in dogs

Journal of pharmacological and toxicological methods, 2014-11, Vol.70 (3), p.336-336

2014

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Evaluation of a prototype software for automated analysis of ECG data from guinea pig & rat in vitro and in vivo models

Journal of pharmacological and toxicological methods, 2010-09, Vol.62 (2), p.e12-e12

2010

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Phosphodiesterase 3 inhibition—Cardiovascular effects and the translation from in vitro to in vivo and across species

Journal of pharmacological and toxicological methods, 2009-09, Vol.60 (2), p.251-251

2009

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Myocardial and renal vascular protection with eplerenone, enalapril and coadministration in the SHHF rat

Journal of cardiac failure, 2003-10, Vol.9 (5), p.S19-S19

2003

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Chapter 29 - The Use of Nonhuman Primates in Cardiovascular Safety Assessment

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment, 2015, p.551-578

2015

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Effects of Chronic PPAR-Agonist Treatment on Cardiac Structure and Function, Blood Pressure, and Kidney in Healthy Sprague-Dawley Rats

PPAR Research, 2009-01, Vol.2009 (1), p.237865-237865

2009

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Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-κB

Brain research. Molecular brain research., 2000-04, Vol.77 (1), p.138-147

2000

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Behavior of Adult and Aged Mice Before and After Central Injection of Interleukin-1β

Physiology & behavior, 1999-06, Vol.66 (4), p.673-679

1999

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THE USE OF ECHOCARDIOGRAPHY IN SAFETY PHARMACOLOGY

Journal of pharmacological and toxicological methods, 2007-09, Vol.56 (2), p.e30-e30

2007

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EFFECTS OF CHRONIC PPAR-AGONIST TREATMENT ON CARDIO-RENAL STRUCTURE, FUNCTION, AND BLOOD PRESSURE IN SPRAGUE–DAWLEY RATS

Journal of pharmacological and toxicological methods, 2007-09, Vol.56 (2), p.e8-e8

2007

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Interleukin-6 Facilitates Lipopolysaccharide-Induced Disruption in Working Memory and Expression of Other Proinflammatory Cytokines in Hippocampal Neuronal Cell Layers

Mechanistic investigation of imatinib-induced cardiac toxicity and the involvement of c-Abl kinase

Characterization, Biomarkers, and Reversibility of a Monoclonal Antibody-induced Immune Complex Disease in Cynomolgus Monkeys (Macaca fascicularis)

Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma

Structural, functional, and molecular characterization of the SHHF model of heart failure

Pan-FGFR inhibition leads to blockade of FGF23 signaling, soft tissue mineralization, and cardiovascular dysfunction

Cardiovascular differentiation of imatinib and bosutinib in the rat

Cardiovascular Effects in Rats following Exposure to a Receptor Tyrosine Kinase Inhibitor

Time course of AQP-2 and ENaC regulation in the kidney in response to PPAR agonists associated with marked edema in rats

Assessment of a novel in vitro assay for early detection of effects on heart rate

Surgical method development and refinement of the blood pressure add-on component in dogs selected for jacketed external telemetry

Ex-vivo investigation of aldosterone-induced endothelial dysfunction in the Rat

Validation of combined toxicology and cardiovascular safety pharmacology studies using JET technology

Structural, functional, and molecular characterization of the SHHF model of heart failure

Health and environmental sciences institute integrated strategies working group: Update on the evaluation of drug-induced changes in the cardiac inotropy in dogs

Evaluation of a prototype software for automated analysis of ECG data from guinea pig & rat in vitro and in vivo models

Phosphodiesterase 3 inhibition—Cardiovascular effects and the translation from in vitro to in vivo and across species

Myocardial and renal vascular protection with eplerenone, enalapril and coadministration in the SHHF rat

Chapter 29 - The Use of Nonhuman Primates in Cardiovascular Safety Assessment

Effects of Chronic PPAR-Agonist Treatment on Cardiac Structure and Function, Blood Pressure, and Kidney in Healthy Sprague-Dawley Rats

Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-κB

Behavior of Adult and Aged Mice Before and After Central Injection of Interleukin-1β

THE USE OF ECHOCARDIOGRAPHY IN SAFETY PHARMACOLOGY

EFFECTS OF CHRONIC PPAR-AGONIST TREATMENT ON CARDIO-RENAL STRUCTURE, FUNCTION, AND BLOOD PRESSURE IN SPRAGUE–DAWLEY RATS

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