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N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids

Food and chemical toxicology, 2016-11, Vol.97, p.23-39

Herraiz, Tomás

2016

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Formation, Identification, and Occurrence of the Furan-Containing β‑Carboline Flazin Derived from l‑Tryptophan and Carbohydrates

Journal of agricultural and food chemistry, 2024-03, Vol.72 (12), p.6575-6584

2024

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Hydroxyl radical reactions and the radical scavenging activity of β-carboline alkaloids

Food chemistry, 2015-04, Vol.172, p.640-649

2015

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Identification, Formation, and Occurrence of Perlolyrine: A β‑Carboline Alkaloid with a Furan Moiety in Foods

Journal of agricultural and food chemistry, 2023-09, Vol.71 (36), p.13451-13461

2023

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Nitrosative deamination of 2′-deoxyguanosine and DNA by nitrite, and antinitrosating activity of β-carboline alkaloids and antioxidants

Food and chemical toxicology, 2018-02, Vol.112, p.282-289

2018

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Analysis of monoamine oxidase (MAO) enzymatic activity by high-performance liquid chromatography-diode array detection combined with an assay of oxidation with a peroxidase and its application to MAO inhibitors from foods and plants

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018-01, Vol.1073, p.136-144

2018

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Naturally-occurring tetrahydro-β-carboline alkaloids derived from tryptophan are oxidized to bioactive β-carboline alkaloids by heme peroxidases

Biochemical and biophysical research communications, 2014-08, Vol.451 (1), p.42-47

2014

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Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents

Journal of enzyme inhibition and medicinal chemistry, 2012-12, Vol.27 (6), p.810-817

Herraiz, Tomás

2012

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β-Carboline Alkaloids in Soy Sauce and Inhibition of Monoamine Oxidase (MAO)

Molecules (Basel, Switzerland), 2023-03, Vol.28 (6), p.2723

Herraiz, Tomás

2023

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Identification and Occurrence of β-Carboline Alkaloids in Raisins and Inhibition of Monoamine Oxidase (MAO)

Journal of agricultural and food chemistry, 2007-10, Vol.55 (21), p.8534-8540

Herraiz, Tomás

2007

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Identification, occurrence and activity of quinazoline alkaloids in Peganum harmala

Food and chemical toxicology, 2017-05, Vol.103, p.261-269

2017

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Occurrence, Formation from d‑Fructose and 3‑Deoxyglucosone, and Activity of the Carbohydrate-Derived β‑Carbolines in Foods

Journal of agricultural and food chemistry, 2021-06, Vol.69 (23), p.6650-6664

2021

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Formation, Characterization, and Occurrence of β‑Carboline Alkaloids Derived from α‑Dicarbonyl Compounds and l‑Tryptophan

Journal of agricultural and food chemistry, 2022-07, Vol.70 (29), p.9143-9153

2022

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Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors

Food and chemical toxicology, 2011-08, Vol.49 (8), p.1773-1781

2011

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5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO)

Drug testing and analysis, 2014-07, Vol.6 (7-8), p.607-613

2014

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Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense

European journal of medicinal chemistry, 2018-04, Vol.150, p.385-402

2018

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Metabolite Profile Resulting from the Activation/Inactivation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-Methyltetrahydro-β-carboline by Oxidative Enzymes

BioMed research international, 2013-01, Vol.2013, p.248608-10

2013

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A new nonpolar N-hydroxy imidazoline lead compound with improved activity in a murine model of late-stage Trypanosoma brucei brucei infection is not cross-resistant with diamidines

Antimicrobial agents and chemotherapy, 2015-02, Vol.59 (2), p.890-904

2015

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Antimalarial Quinoline Drugs Inhibit β-Hematin and Increase Free Hemin Catalyzing Peroxidative Reactions and Inhibition of Cysteine Proteases

Scientific reports, 2019-10, Vol.9 (1), p.15398-16, Article 15398

2019

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Discovery and Pharmacological Studies of 4‑Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis

Journal of medicinal chemistry, 2019-12, Vol.62 (23), p.10664-10675

2019

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Synthesis and Biophysical and Biological Studies of N‑Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites

Journal of medicinal chemistry, 2023-10, Vol.66 (19), p.13452-13480

2023

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N-Methyltetrahydro-β-carboline analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin are oxidized to neurotoxic β-carbolinium cations by heme peroxidases

Biochemical and biophysical research communications, 2007-04, Vol.356 (1), p.118-123

2007

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Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO)

Free radical research, 2009-01, Vol.43 (10), p.975-984

2009

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Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated β-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6

Toxicology and applied pharmacology, 2006-11, Vol.216 (3), p.387-398

2006

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Oxidative Metabolism of the Bioactive and Naturally Occurring β-Carboline Alkaloids, Norharman and Harman, by Human Cytochrome P450 Enzymes

Chemical research in toxicology, 2008-11, Vol.21 (11), p.2172-2180

2008

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N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids

Formation, Identification, and Occurrence of the Furan-Containing β‑Carboline Flazin Derived from l‑Tryptophan and Carbohydrates

Hydroxyl radical reactions and the radical scavenging activity of β-carboline alkaloids

Identification, Formation, and Occurrence of Perlolyrine: A β‑Carboline Alkaloid with a Furan Moiety in Foods

Nitrosative deamination of 2′-deoxyguanosine and DNA by nitrite, and antinitrosating activity of β-carboline alkaloids and antioxidants

Analysis of monoamine oxidase (MAO) enzymatic activity by high-performance liquid chromatography-diode array detection combined with an assay of oxidation with a peroxidase and its application to MAO inhibitors from foods and plants

Naturally-occurring tetrahydro-β-carboline alkaloids derived from tryptophan are oxidized to bioactive β-carboline alkaloids by heme peroxidases

Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents

β-Carboline Alkaloids in Soy Sauce and Inhibition of Monoamine Oxidase (MAO)

Identification and Occurrence of β-Carboline Alkaloids in Raisins and Inhibition of Monoamine Oxidase (MAO)

Identification, occurrence and activity of quinazoline alkaloids in Peganum harmala

Occurrence, Formation from d‑Fructose and 3‑Deoxyglucosone, and Activity of the Carbohydrate-Derived β‑Carbolines in Foods

Formation, Characterization, and Occurrence of β‑Carboline Alkaloids Derived from α‑Dicarbonyl Compounds and l‑Tryptophan

Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors

5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO)

Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense

Metabolite Profile Resulting from the Activation/Inactivation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-Methyltetrahydro-β-carboline by Oxidative Enzymes

A new nonpolar N-hydroxy imidazoline lead compound with improved activity in a murine model of late-stage Trypanosoma brucei brucei infection is not cross-resistant with diamidines

Antimalarial Quinoline Drugs Inhibit β-Hematin and Increase Free Hemin Catalyzing Peroxidative Reactions and Inhibition of Cysteine Proteases

Discovery and Pharmacological Studies of 4‑Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis

Synthesis and Biophysical and Biological Studies of N‑Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites

N-Methyltetrahydro-β-carboline analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin are oxidized to neurotoxic β-carbolinium cations by heme peroxidases

Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO)

Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated β-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6

Oxidative Metabolism of the Bioactive and Naturally Occurring β-Carboline Alkaloids, Norharman and Harman, by Human Cytochrome P450 Enzymes

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