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A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?

Diabetes (New York, N.Y.), 2016-06, Vol.65 (6), p.1472-1480

2016

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The role of de novo protein synthesis and SIRT1 in ER stress-induced Atf4 and Chop mRNA expression in mammalian cells

Biochimie, 2017-07, Vol.138, p.156-167

2017

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Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21

PloS one, 2017-04, Vol.12 (4), p.e0173676

2017

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cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity

Cellular signalling, 2011-12, Vol.23 (12), p.1927-1935

2011

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A decrease in cellular energy status stimulates PERK-dependent eIF2α phosphorylation and regulates protein synthesis in pancreatic β-cells

Biochemical journal, 2008-03, Vol.410 (3), p.485-493

2008

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Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1

PloS one, 2012-03, Vol.7 (3), p.e33004-e33004

2012

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Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1

Journal of molecular endocrinology, 2014-08, Vol.53 (1), p.105-115

2014

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The Extracellular Signal-regulated Kinase Pathway Regulates the Phosphorylation of 4E-BP1 at Multiple Sites

The Journal of biological chemistry, 2002-03, Vol.277 (13), p.11591-11596

2002

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The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes

Cellular and molecular life sciences : CMLS, 2012-04, Vol.69 (8), p.1289-1304

2012

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Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes

Molecular and cellular endocrinology, 2022-10, Vol.556, p.111740-111740, Article 111740

2022

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Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response

Endocrinology (Philadelphia), 2017-10, Vol.158 (10), p.3162-3173

2017

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Distinct glucose-dependent stress responses revealed by translational profiling in pancreatic β-cells

Journal of endocrinology, 2007-01, Vol.192 (1), p.179-187

2007

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Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells

Antioxidants & redox signaling, 2014-05, Vol.20 (14), p.2091

2014

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System-L amino acid transporters play a key role in pancreatic β-cell signalling and function

Journal of molecular endocrinology, 2016-04, Vol.56 (3), p.175-187

2016

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3',4'-dihydroxyflavonol ameliorates endoplasmic reticulum stress-induced apoptosis and endothelial dysfunction in mice

Scientific reports, 2018-01, Vol.8 (1), p.1818-10, Article 1818

2018

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The inositol-requiring enzyme 1 (IRE1α) RNAse inhibitor, 4µ8C, is also a potent cellular antioxidant

Biochemical journal, 2018-03, Vol.475 (5), p.923-929

2018

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Endoplasmic reticulum stress up‐regulates Nedd4‐2 to induce autophagy

The FASEB journal, 2016-07, Vol.30 (7), p.2549-2556

2016

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PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells

Molecular endocrinology (Baltimore, Md.), 2011-02, Vol.25 (2), p.315-326

2011

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cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells

The Journal of biological chemistry, 2002-12, Vol.277 (50), p.48146-48151

2002

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Identification of cAMP-Dependent Kinase as a Third in Vivo Ribosomal Protein S6 Kinase in Pancreatic β-Cells

Journal of molecular biology, 2009-06, Vol.389 (3), p.480-494

2009

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The selective recruitment of mRNA to the ER and an increase in initiation are important for glucose-stimulated proinsulin synthesis in pancreatic beta-cells

Biochemical journal, 2005-10, Vol.391 (Pt 2), p.291-300

2005

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Dexamethasone acutely suppresses the anabolic SNAT2/SLC38A2 amino acid transporter protein in L6‐G8C5 rat skeletal muscle cells

FASEB bioAdvances, 2021-01, Vol.3 (1), p.36-48

2021

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Inhibition of SNAT2 by Metabolic Acidosis Enhances Proteolysis in Skeletal Muscle

Journal of the American Society of Nephrology, 2008-11, Vol.19 (11), p.2119-2129

2008

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Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells

Journal of the American Society of Nephrology, 2007-05, Vol.18 (5), p.1426-1436

2007

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PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells

The journal of clinical endocrinology and metabolism, 2011-02, Vol.96 (2), p.557-557

2011

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A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?

The role of de novo protein synthesis and SIRT1 in ER stress-induced Atf4 and Chop mRNA expression in mammalian cells

Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity

A decrease in cellular energy status stimulates PERK-dependent eIF2α phosphorylation and regulates protein synthesis in pancreatic β-cells

Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1

Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1

The Extracellular Signal-regulated Kinase Pathway Regulates the Phosphorylation of 4E-BP1 at Multiple Sites

The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes

Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes

Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response

Distinct glucose-dependent stress responses revealed by translational profiling in pancreatic β-cells

Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells

System-L amino acid transporters play a key role in pancreatic β-cell signalling and function

3',4'-dihydroxyflavonol ameliorates endoplasmic reticulum stress-induced apoptosis and endothelial dysfunction in mice

The inositol-requiring enzyme 1 (IRE1α) RNAse inhibitor, 4µ8C, is also a potent cellular antioxidant

Endoplasmic reticulum stress up‐regulates Nedd4‐2 to induce autophagy

PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells

cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells

Identification of cAMP-Dependent Kinase as a Third in Vivo Ribosomal Protein S6 Kinase in Pancreatic β-Cells

The selective recruitment of mRNA to the ER and an increase in initiation are important for glucose-stimulated proinsulin synthesis in pancreatic beta-cells

Dexamethasone acutely suppresses the anabolic SNAT2/SLC38A2 amino acid transporter protein in L6‐G8C5 rat skeletal muscle cells

Inhibition of SNAT2 by Metabolic Acidosis Enhances Proteolysis in Skeletal Muscle

Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells

PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells

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