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Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)

ChemMedChem, 2016-07, Vol.11 (14), p.1517-1530

2016

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Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region

Journal of medicinal chemistry, 2014-06, Vol.57 (11), p.4584-4597

2014

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On the Total Synthesis and Determination of the Absolute Configuration of Rishirilide B: Exploitation of Subtle Effects to Control the Sense of Cycloaddition of o-Quinodimethides

Chemistry : a European journal, 2003-07, Vol.9 (14), p.3242-3252

2003

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A Powerful o-Quinone Dimethide Strategy for Intermolecular Diels−Alder Cycloadditions

Journal of the American Chemical Society, 2000-02, Vol.122 (4), p.571-575

2000

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Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK)

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.10010-10021

2012

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In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound

ACS chemical biology, 2012-11, Vol.7 (11), p.1866-1872

2012

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The Origin of endo Stereoselectivity in the Hetero-Diels-Alder Reactions of Aldehydes with ortho-Xylylenes: CH-π, π-π, and Steric Effects on Stereoselectivity

Chemistry : a European journal, 2002-08, Vol.8 (15), p.3423-3430

2002

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Concise Stereoselective Routes to Advanced Intermediates Related to Natural and Unnatural Pinnaic Acid This work was supported by the National Institutes of Health (Grant Numbers: CA28824). Postdoctoral Fellowship support is gratefully acknowledged by M.W.C. (U.S. Army BCRP, DAMD17-98-1-8154), M.F.H. (5T32 CA62948-05), and D.T. (Schering Research Foundation, Berlin). We thank Dr. George Sukenick of the MSKCC NMR Core Facility for NMR and mass spectral analyses

Angewandte Chemie International Edition, 2001-12, Vol.40 (23), p.4450-4452

2001

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Concise Stereoselective Routes to Advanced Intermediates Related to Natural and Unnatural Pinnaic Acid

Angewandte Chemie International Edition, 2001-12, Vol.40 (23), p.4450-4452

2001

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Thermal Intermolecular Hetero Diels-Alder Cycloadditions of Aldehydes and Imines via o-Quinone Dimethides

Angewandte Chemie International Edition, 2000-06, Vol.39 (11), p.1937-1940

2000

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Concise Stereoselective Routes to Advanced Intermediates Related to Natural and Unnatural Pinnaic Acid

Angewandte Chemie, 2001-12, Vol.113 (23), p.4582-4584

2001

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Thermal Intermolecular Hetero Diels–Alder Cycloadditions of Aldehydes and Imines viao-Quinone Dimethides

Angewandte Chemie International Edition, 2000-06, Vol.39 (11), p.1937-1940

2000

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Synthesis and oxidation reactions of cycloheptatrienyl sulfones

Tetrahedron letters, 2000-10, Vol.41 (41), p.7795-7799

2000

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Thermal Intermolecular Hetero Diels–Alder Cycloadditions of Aldehydes and Imines viao-Quinone Dimethides

Angewandte Chemie, 2000-06, Vol.112 (11), p.2013-2016

2000

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Concise Stereoselective Routes to Advanced Intermediates Related to Natural and Unnatural Pinnaic Acid

Angewandte Chemie, 2001-12, Vol.113 (23), p.4582-4584

2001

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Thermal Intermolecular Hetero Diels-Alder Cycloadditions of Aldehydes and Imines via o-Quinone Dimethides

Angewandte Chemie, 2000-06, Vol.112 (11), p.2013-2016

2000

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ChemInform Abstract: Synthesis and Oxidation Reactions of Cycloheptatrienyl Sulfones

ChemInform, 2000-12, Vol.31 (52), p.no-no

2000

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ChemInform Abstract: Thermal Intermolecular Hetero Diels-Alder Cycloadditions of Aldehydes and Imines via o-Quinone Dimethides

ChemInform, 2000-08, Vol.31 (35), p.no-no

2000

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Total Synthesis and Determination of the Absolute Configuration of Rishirilide B: Exploitation of Subtle Effects to Control the Sense of Cycloaddition of o-Quinodimethides

ChemInform, 2003-11, Vol.34 (45), p.no-no

2003

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ChemInform Abstract: A Powerful o-Quinone Dimethide Strategy for Intermolecular Diels-Alder Cycloadditions

ChemInform, 2000-04, Vol.31 (17), p.no-no

2000

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ChemInform Abstract: Concise Stereoselective Routes to Advanced Intermediates Related to Natural and Unnatural Pinnaic Acid

ChemInform, 2002-05, Vol.33 (18), p.no-no

2002

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Abstract 1224: Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1224-1224

2021

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Abstract A064: Establishing the cellular and molecular impacts of the dual BRM/BRG1 inhibitor FHD-286 on pre-clinical models of non-small cell lung cancer (NSCLC)

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.A064-A064

2023

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Abstract LB190: Modulation of SPI1 transcriptional program contributes to the preclinical anti-tumor activity of SMARCA4/SMARCA2 ATPase inhibitors in AML

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.LB190-LB190

2022

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Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)

Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region

On the Total Synthesis and Determination of the Absolute Configuration of Rishirilide B: Exploitation of Subtle Effects to Control the Sense of Cycloaddition of o-Quinodimethides

A Powerful o-Quinone Dimethide Strategy for Intermolecular Diels−Alder Cycloadditions

Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK)

In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound

The Origin of endo Stereoselectivity in the Hetero-Diels-Alder Reactions of Aldehydes with ortho-Xylylenes: CH-π, π-π, and Steric Effects on Stereoselectivity

Concise Stereoselective Routes to Advanced Intermediates Related to Natural and Unnatural Pinnaic Acid

Thermal Intermolecular Hetero Diels-Alder Cycloadditions of Aldehydes and Imines via o-Quinone Dimethides

Concise Stereoselective Routes to Advanced Intermediates Related to Natural and Unnatural Pinnaic Acid

Thermal Intermolecular Hetero Diels–Alder Cycloadditions of Aldehydes and Imines viao-Quinone Dimethides

Synthesis and oxidation reactions of cycloheptatrienyl sulfones

Thermal Intermolecular Hetero Diels–Alder Cycloadditions of Aldehydes and Imines viao-Quinone Dimethides

Concise Stereoselective Routes to Advanced Intermediates Related to Natural and Unnatural Pinnaic Acid

Thermal Intermolecular Hetero Diels-Alder Cycloadditions of Aldehydes and Imines via o-Quinone Dimethides

ChemInform Abstract: Synthesis and Oxidation Reactions of Cycloheptatrienyl Sulfones

ChemInform Abstract: Thermal Intermolecular Hetero Diels-Alder Cycloadditions of Aldehydes and Imines via o-Quinone Dimethides

Total Synthesis and Determination of the Absolute Configuration of Rishirilide B: Exploitation of Subtle Effects to Control the Sense of Cycloaddition of o-Quinodimethides

ChemInform Abstract: A Powerful o-Quinone Dimethide Strategy for Intermolecular Diels-Alder Cycloadditions

ChemInform Abstract: Concise Stereoselective Routes to Advanced Intermediates Related to Natural and Unnatural Pinnaic Acid

Abstract 1224: Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers

Abstract A064: Establishing the cellular and molecular impacts of the dual BRM/BRG1 inhibitor FHD-286 on pre-clinical models of non-small cell lung cancer (NSCLC)

Abstract LB190: Modulation of SPI1 transcriptional program contributes to the preclinical anti-tumor activity of SMARCA4/SMARCA2 ATPase inhibitors in AML

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