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Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis

Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (8)

2022

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Unjamming and cell shape in the asthmatic airway epithelium

Nature materials, 2015-10, Vol.14 (10), p.1040-1048

2015

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Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment

Nature communications, 2022-08, Vol.13 (1), p.5018-5018, Article 5018

2022

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Renal disease in tuberous sclerosis complex: pathogenesis and therapy

Nature reviews. Nephrology, 2018-11, Vol.14 (11), p.704

2018

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The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

Cell, 2013-05, Vol.153 (4), p.840-854

2013

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mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion

Nature communications, 2023-03, Vol.14 (1), p.1214-1214, Article 1214

2023

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TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism

Nature communications, 2021-07, Vol.12 (1), p.4245-4245, Article 4245

2021

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Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

The Journal of experimental medicine, 2014-10, Vol.211 (11), p.2249-2263

2014

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Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1

The Journal of clinical investigation, 2023-11, Vol.133 (21), p.1-16

2023

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Loss of FLCN inhibits canonical WNT signaling via TFE3

Human molecular genetics, 2019-10, Vol.28 (19), p.3270-3281

2019

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Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma

Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (27), p.E6274-E6282

2018

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Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development

PLoS genetics, 2016-08, Vol.12 (8), p.e1006242

2016

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Renal Cell Carcinoma in Tuberous Sclerosis Complex

Genes, 2021-10, Vol.12 (10), p.1585

2021

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Mechanisms of pulmonary cyst pathogenesis in Birt–Hogg–Dube syndrome: The stretch hypothesis

Seminars in cell & developmental biology, 2016-04, Vol.52, p.47-52

2016

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Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (6)

2021

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MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61

Oncogene, 2021-01, Vol.40 (1), p.112-126

2021

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TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex

Nature communications, 2024-01, Vol.15 (1), p.406-406, Article 406

2024

Volltextzugriff (PDF)

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

Cell, 2021-04, Vol.184 (8), p.2256-2256

2021

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mTOR Is Activated in the Majority of Malignant Melanomas

Journal of investigative dermatology, 2008-04, Vol.128 (4), p.980-987

2008

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Activation of the mTOR signaling pathway in renal clear cell carcinoma

The Journal of urology, 2007-01, Vol.177 (1), p.346

2007

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Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion

PloS one, 2012-11, Vol.7 (11), p.e47842-e47842

2012

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Lymphangioleiomyomatosis - a wolf in sheep's clothing

The Journal of clinical investigation, 2012-11, Vol.122 (11), p.3807-3816

2012

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Human Pluripotent Stem Cell-Derived TSC2 -Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis

Cancer research (Chicago, Ill.), 2017-10, Vol.77 (20), p.5491-5502

2017

Volltextzugriff (PDF)

Keeping up with the Rag GTPases

Nature cell biology, 2022-09, Vol.24 (9), p.1330

2022

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The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back

Frontiers in cell and developmental biology, 2021-10, Vol.9, p.751892

2021

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Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis

Unjamming and cell shape in the asthmatic airway epithelium

Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment

Renal disease in tuberous sclerosis complex: pathogenesis and therapy

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion

TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1

Loss of FLCN inhibits canonical WNT signaling via TFE3

Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma

Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development

Renal Cell Carcinoma in Tuberous Sclerosis Complex

Mechanisms of pulmonary cyst pathogenesis in Birt–Hogg–Dube syndrome: The stretch hypothesis

Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex

MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61

TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

mTOR Is Activated in the Majority of Malignant Melanomas

Activation of the mTOR signaling pathway in renal clear cell carcinoma

Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion

Lymphangioleiomyomatosis - a wolf in sheep's clothing

Human Pluripotent Stem Cell-Derived TSC2 -Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis

Keeping up with the Rag GTPases

The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back

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