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Supersaturation and Precipitation of Posaconazole Upon Entry in the Upper Small Intestine in Humans

Journal of pharmaceutical sciences, 2016-09, Vol.105 (9), p.2677-2684

2016

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Gastrointestinal behavior of nano- and microsized fenofibrate: In vivo evaluation in man and in vitro simulation by assessment of the permeation potential

European journal of pharmaceutical sciences, 2015-09, Vol.77, p.40-47

2015

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Favipiravir at high doses has potent antiviral activity in SARS-CoV-2–infected hamsters, whereas hydroxychloroquine lacks activity

Proceedings of the National Academy of Sciences - PNAS, 2020-10, Vol.117 (43), p.26955-26965

2020

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Persistent Threats by Persistent Pollutants: Chemical Nature, Concerns and Future Policy Regarding PCBs-What Are We Heading For?

Toxics (Basel), 2017-12, Vol.6 (1), p.1

2017

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Gastrointestinal and Systemic Monitoring of Posaconazole in Humans After Fasted and Fed State Administration of a Solid Dispersion

Journal of pharmaceutical sciences, 2016-09, Vol.105 (9), p.2904-2912

2016

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The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group

European journal of pharmaceutical sciences, 2019-06, Vol.134, p.31-59

2019

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Voices in Molecular Pharmaceutics : Meet Dr. Bart Hens, A Sociable Scientist Focusing on Multidisciplinary Connections to Unravel the Gaps of Oral Drug Behavior in the Human Gastrointestinal Tract

Molecular pharmaceutics, 2023-12, Vol.20 (12), p.5952-5953

Hens, Bart

2023

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Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs

Molecular pharmaceutics, 2017-12, Vol.14 (12), p.4281-4294

2017

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A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

Pharmaceutics, 2020-01, Vol.12 (1), p.74

2020

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Haematoma evacuation in cerebellar intracerebral haemorrhage: systematic review

Journal of neurology, neurosurgery and psychiatry, 2020-01, Vol.91 (1), p.82-87

2020

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Bile Salt Micelles and Phospholipid Vesicles Present in Simulated and Human Intestinal Fluids: Structural Analysis by Flow Field–Flow Fractionation/Multiangle Laser Light Scattering

Journal of pharmaceutical sciences, 2016-09, Vol.105 (9), p.2832-2839

2016

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Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate–CO2 Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance

Molecular pharmaceutics, 2018-11, Vol.15 (11), p.5291-5301

2018

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Measuring the Impact of Gastrointestinal Variables on the Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model

The AAPS journal, 2018-03, Vol.20 (3), p.57-57, Article 57

2018

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Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach

European journal of pharmaceutics and biopharmaceutics, 2018-08, Vol.129, p.162-174

2018

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Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola® on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b)

Pharmaceutics, 2020-06, Vol.12 (6), p.566

2020

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Biopredictive in vitro testing methods to assess intestinal drug absorption from supersaturating dosage forms

Journal of drug delivery science and technology, 2020-04, Vol.56, p.101275, Article 101275

2020

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An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products

Pharmaceutics, 2021-04, Vol.13 (4), p.507

2021

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Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare

Frontiers in medicine, 2021-03, Vol.8, p.480706-480706

2021

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Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

Pharmaceutics, 2019-03, Vol.11 (3), p.122

2019

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Exploring the Predictive Power of the In Situ Perfusion Technique towards Drug Absorption: Theory, Practice, and Applications

Molecular pharmaceutics, 2022-03, Vol.19 (3), p.749-762

2022

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Application of a Dynamic Fluid and pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus

Journal of pharmaceutical sciences, 2019-01, Vol.108 (1), p.305-315

2019

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Digitalizing the TIM‑1 Model Using Computational ApproachesPart Two: Digital TIM‑1 Model in GastroPlus

Molecular pharmaceutics, 2023-11, Vol.20 (11), p.5429-5439

2023

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Digitalizing the TIM‑1 Model using Computational Approaches–Part One: TIM‑1 Data Explorer

Molecular pharmaceutics, 2023-11, Vol.20 (11), p.5416-5428

2023

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A review of drug solubility in human intestinal fluids: Implications for the prediction of oral absorption

European journal of pharmaceutical sciences, 2014-06, Vol.57, p.322-332

2014

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Supersaturation and Precipitation of Posaconazole Upon Entry in the Upper Small Intestine in Humans

Gastrointestinal behavior of nano- and microsized fenofibrate: In vivo evaluation in man and in vitro simulation by assessment of the permeation potential

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2–infected hamsters, whereas hydroxychloroquine lacks activity

Persistent Threats by Persistent Pollutants: Chemical Nature, Concerns and Future Policy Regarding PCBs-What Are We Heading For?

Gastrointestinal and Systemic Monitoring of Posaconazole in Humans After Fasted and Fed State Administration of a Solid Dispersion

The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group

Voices in Molecular Pharmaceutics : Meet Dr. Bart Hens, A Sociable Scientist Focusing on Multidisciplinary Connections to Unravel the Gaps of Oral Drug Behavior in the Human Gastrointestinal Tract

Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs

A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

Haematoma evacuation in cerebellar intracerebral haemorrhage: systematic review

Bile Salt Micelles and Phospholipid Vesicles Present in Simulated and Human Intestinal Fluids: Structural Analysis by Flow Field–Flow Fractionation/Multiangle Laser Light Scattering

Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate–CO2 Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance

Measuring the Impact of Gastrointestinal Variables on the Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model

Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach

Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola® on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b)

Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants

Biopredictive in vitro testing methods to assess intestinal drug absorption from supersaturating dosage forms

An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products

Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

Exploring the Predictive Power of the In Situ Perfusion Technique towards Drug Absorption: Theory, Practice, and Applications

Application of a Dynamic Fluid and pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus

Digitalizing the TIM‑1 Model Using Computational ApproachesPart Two: Digital TIM‑1 Model in GastroPlus

Digitalizing the TIM‑1 Model using Computational Approaches–Part One: TIM‑1 Data Explorer

A review of drug solubility in human intestinal fluids: Implications for the prediction of oral absorption

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