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Select animal models of colitis and their value in predicting clinical efficacy of biological therapies in ulcerative colitis

Expert opinion on drug discovery, 2021-05, Vol.16 (5), p.567-577

2021

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Discovery of Highly Selective and Potent p38 Inhibitors Based on a Phthalazine Scaffold

Journal of medicinal chemistry, 2008-10, Vol.51 (20), p.6271-6279

2008

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Discovery of Pyridazinopyridinones as Potent and Selective p38 Mitogen-Activated Protein Kinase Inhibitors

Journal of medicinal chemistry, 2010-09, Vol.53 (17), p.6398-6411

2010

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Adenoviral Gene Transfer Is Inhibited by Soluble Factors in Malignant Pleural Effusions

American journal of respiratory cell and molecular biology, 2000-05, Vol.22 (5), p.613-619

2000

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Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (9), p.2409-2413

2005

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Part 2: Structure–activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1680-1684

2010

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3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38α Mitogen-Activated Protein Kinase

Journal of medicinal chemistry, 2008-10, Vol.51 (20), p.6280-6292

2008

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Part 1: Structure–Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4724-4728

2009

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Identification of triazolopyridazinones as potent p38α inhibitors

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.1226-1229

2012

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Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38a mitogen-activated protein kinase

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1680-1684

2010

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Discovery and Evaluation of 7-Alkyl-1,5-bis-aryl-pyrazolopyridinones as Highly Potent, Selective, and Orally Efficacious Inhibitors of p38α Mitogen-Activated Protein Kinase ⊥ Atomic coordinates and structure factors for crystal structure of compound 3d with p38α can be accessed using PDB code 3LHJ

Journal of medicinal chemistry, 2010-04, Vol.53 (7), p.2973-2985

2010

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3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38a Mitogen-Activated Protein Kinase

Journal of medicinal chemistry, 2008, Vol.51 (20), p.6280-6292

2008

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Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1680-1684

2010

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Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4724-4728

2009

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Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase

Journal of medicinal chemistry, 2010-04, Vol.53 (7), p.2973-2985

2010

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3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase

Journal of medicinal chemistry, 2008-10, Vol.51 (20), p.6280

2008

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Autoimmunity to bactericidal/permeability-increasing protein in bronchiectasis exhibits a requirement for Pseudomonas aeruginosa IgG response

The European respiratory journal, 2019-02, Vol.53 (2), p.1801891

2019

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Select animal models of colitis and their value in predicting clinical efficacy of biological therapies in ulcerative colitis

Discovery of Highly Selective and Potent p38 Inhibitors Based on a Phthalazine Scaffold

Discovery of Pyridazinopyridinones as Potent and Selective p38 Mitogen-Activated Protein Kinase Inhibitors

Adenoviral Gene Transfer Is Inhibited by Soluble Factors in Malignant Pleural Effusions

Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase

Part 2: Structure–activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38α Mitogen-Activated Protein Kinase

Part 1: Structure–Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

Identification of triazolopyridazinones as potent p38α inhibitors

Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38a mitogen-activated protein kinase

3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38a Mitogen-Activated Protein Kinase

Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase

Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase

Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase

3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase

Autoimmunity to bactericidal/permeability-increasing protein in bronchiectasis exhibits a requirement for Pseudomonas aeruginosa IgG response

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