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Translation Regulation as a Therapeutic Target in Cancer

Cancer research (Chicago, Ill.), 2012-08, Vol.72 (16), p.3891-3900

2012

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NDR Functions as a Physiological YAP1 Kinase in the Intestinal Epithelium

Current biology, 2015-02, Vol.25 (3), p.296-305

2015

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Structure, regulation and function of PKB/AKT—a major therapeutic target

BBA - Proteins and Proteomics, 2004-03, Vol.1697 (1-2), p.3-16

2004

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Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

The American journal of pathology, 2008-08, Vol.173 (2), p.451-462

2008

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Human NDR Kinases Control G1/S Cell Cycle Transition by Directly Regulating p21 Stability

Molecular and Cellular Biology, 2011-04, Vol.31 (7), p.1382-1395

2011

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PKB and the mitochondria: AKTing on apoptosis

Cellular signalling, 2008, Vol.20 (1), p.21-30

2008

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Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase

The Journal of biological chemistry, 2004-09, Vol.279 (39), p.41189-41196

2004

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Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET

Journal of cell science, 2012-11, Vol.125 (Pt 22), p.5391-5402

2012

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Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

PLoS biology, 2007-04, Vol.5 (4), p.e95-791

2007

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NDR Kinase Is Activated by RASSF1A/MST1 in Response to Fas Receptor Stimulation and Promotes Apoptosis

Current biology, 2008-12, Vol.18 (23), p.1889-1895

2008

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Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies

Molecular and Cellular Biology, 2006-11, Vol.26 (21), p.8042-8051

2006

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PKB/Akt―Dependent Regulation of Cell Motility

JNCI : Journal of the National Cancer Institute, 2013-03, Vol.105 (6), p.393-404

2013

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S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt

Biochemical journal, 2012-01, Vol.441 (1), p.199-207

2012

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Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling

BioFactors (Oxford), 2009-07, Vol.35 (4), p.338-345

2009

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The MST1 and hMOB1 Tumor Suppressors Control Human Centrosome Duplication by Regulating NDR Kinase Phosphorylation

Current biology, 2009-11, Vol.19 (20), p.1692-1702

2009

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Downstream of human NDR kinases: Impacting on c-myc and p21 protein stability to control cell cycle progression

Cell cycle (Georgetown, Tex.), 2011-06, Vol.10 (12), p.1897-1904

2011

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SYK inhibition blocks proliferation and migration of glioma cells and modifies the tumor microenvironment

Neuro-oncology (Charlottesville, Va.), 2018-04, Vol.20 (5), p.621-631

2018

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Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival

PloS one, 2013-02, Vol.8 (2), p.e57793-e57793

2013

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PI3K-PKB/Akt pathway

Cold Spring Harbor perspectives in biology, 2012-09, Vol.4 (9), p.a011189-a011189

2012

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Phosphorylation of basic helix-loop-helix transcription factor Twist in development and disease

Biochemical Society transactions, 2012-02, Vol.40 (1), p.90

2012

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Regulation of protein kinase cascades by protein phosphatase 2A

Trends in Biochemical Sciences, 1999-05, Vol.24 (5), p.186-191

1999

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Stabilization of Mdm2 via Decreased Ubiquitination Is Mediated by Protein Kinase B/Akt-dependent Phosphorylation

The Journal of biological chemistry, 2004-08, Vol.279 (34), p.35510-35517

2004

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Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation

Molecular cell, 2002-06, Vol.9 (6), p.1227-1240

2002

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In Vivo Analysis of Protein Kinase B (PKB)/Akt Regulation in DNA-PKcs-null Mice Reveals a Role for PKB/Akt in DNA Damage Response and Tumorigenesis

The Journal of biological chemistry, 2008-10, Vol.283 (44), p.30025-30033

2008

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Dosage-Dependent Effects of Akt1/Protein Kinase Bα (PKBα) and Akt3/PKBγ on Thymus, Skin, and Cardiovascular and Nervous System Development in Mice

Molecular and Cellular Biology, 2005-12, Vol.25 (23), p.10407-10418

2005

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Translation Regulation as a Therapeutic Target in Cancer

NDR Functions as a Physiological YAP1 Kinase in the Intestinal Epithelium

Structure, regulation and function of PKB/AKT—a major therapeutic target

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

Human NDR Kinases Control G1/S Cell Cycle Transition by Directly Regulating p21 Stability

PKB and the mitochondria: AKTing on apoptosis

Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase

Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

NDR Kinase Is Activated by RASSF1A/MST1 in Response to Fas Receptor Stimulation and Promotes Apoptosis

Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies

PKB/Akt―Dependent Regulation of Cell Motility

S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt

Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling

The MST1 and hMOB1 Tumor Suppressors Control Human Centrosome Duplication by Regulating NDR Kinase Phosphorylation

Downstream of human NDR kinases: Impacting on c-myc and p21 protein stability to control cell cycle progression

SYK inhibition blocks proliferation and migration of glioma cells and modifies the tumor microenvironment

Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival

PI3K-PKB/Akt pathway

Phosphorylation of basic helix-loop-helix transcription factor Twist in development and disease

Regulation of protein kinase cascades by protein phosphatase 2A

Stabilization of Mdm2 via Decreased Ubiquitination Is Mediated by Protein Kinase B/Akt-dependent Phosphorylation

Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation

In Vivo Analysis of Protein Kinase B (PKB)/Akt Regulation in DNA-PKcs-null Mice Reveals a Role for PKB/Akt in DNA Damage Response and Tumorigenesis

Dosage-Dependent Effects of Akt1/Protein Kinase Bα (PKBα) and Akt3/PKBγ on Thymus, Skin, and Cardiovascular and Nervous System Development in Mice

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