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Dynamic ion channel defies dogma

Nature (London), 2023-09, Vol.621 (7977), p.46-47

Hellmich, Ute A.

2023

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Diverse relations between ABC transporters and lipids: An overview

Biochimica et biophysica acta. Biomembranes, 2017-04, Vol.1859 (4), p.605-618

2017

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Comparison of mechanistic transport cycle models of ABC exporters

Biochimica et biophysica acta. Biomembranes, 2018-04, Vol.1860 (4), p.818-832

2018

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TRP channels: branching out into the fungal kingdom

Structure (London), 2022-01, Vol.30 (1), p.2-4

2022

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Unstructural Biology of TRP Ion Channels: The Role of Intrinsically Disordered Regions in Channel Function and Regulation

Journal of molecular biology, 2021-08, Vol.433 (17), p.166931-166931, Article 166931

2021

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What monomeric nucleotide binding domains can teach us about dimeric ABC proteins

FEBS letters, 2020-12, Vol.594 (23), p.3857-3875

2020

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Functional modulation of chemical mediators in microbial communities

Trends in biochemical sciences (Amsterdam. Regular ed.), 2023-01, Vol.48 (1), p.71-81

2023

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Methionine in a protein hydrophobic core drives tight interactions required for assembly of spider silk

Nature communications, 2019-09, Vol.10 (1), p.4378-14, Article 4378

2019

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Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes

The Journal of biological chemistry, 2021-01, Vol.296, p.100565, Article 100565

2021

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Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases-Studies on Inhibition Mechanism and Kinetics

Molecules (Basel, Switzerland), 2020-04, Vol.25 (9), p.2064

2020

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The incredible diversity of structures and functions of ABC transporters

FEBS letters, 2021-03, Vol.595 (6), p.671-674

2021

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Trapping of a Polyketide Synthase Module after C−C Bond Formation Reveals Transient Acyl Carrier Domain Interactions

Angewandte Chemie International Edition, 2024-02, Vol.63 (9), p.e202315850-n/a

International ed. in English, 2024

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Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense

European journal of medicinal chemistry, 2022-06, Vol.236, p.114328-114328, Article 114328

2022

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Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (23), p.9553-9558

2013

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Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis

Journal of medicinal chemistry, 2019-12, Vol.62 (23), p.10617-10629

2019

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Proline-Based Allosteric Inhibitors of Zika and Dengue Virus NS2B/NS3 Proteases

Journal of medicinal chemistry, 2019-12, Vol.62 (24), p.11359-11382

2019

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Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity

Nature communications, 2023-07, Vol.14 (1), p.4165-4165, Article 4165

2023

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New peptidomimetic rhodesain inhibitors with improved selectivity towards human cathepsins

European journal of medicinal chemistry, 2022-08, Vol.238, p.114460-114460, Article 114460

2022

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Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function

Nature communications, 2022-12, Vol.13 (1), p.7483-7483, Article 7483

2022

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Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

Nature communications, 2021-03, Vol.12 (1), p.1444-1444, Article 1444

2021

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Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP 2

Structure (London), 2018-12, Vol.26 (12), p.1583

2018

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New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the Trypanosoma Protease Rhodesain

Molecules (Basel, Switzerland), 2020-03, Vol.25 (6), p.1451

2020

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[4.3.1] Bicyclic FKBP ligands inhibit Legionella pneumophila infection by LpMip-dependent and LpMip independent mechanisms

Chembiochem : a European journal of chemical biology, 2023-11, Vol.24 (21), p.e202300442-e202300442

2023

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Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP2

Structure (London), 2018-12, Vol.26 (12), p.1583-1593.e5

2018

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Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure–Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies

Journal of medicinal chemistry, 2021-08, Vol.64 (16), p.12322-12358

2021

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Dynamic ion channel defies dogma

Diverse relations between ABC transporters and lipids: An overview

Comparison of mechanistic transport cycle models of ABC exporters

TRP channels: branching out into the fungal kingdom

Unstructural Biology of TRP Ion Channels: The Role of Intrinsically Disordered Regions in Channel Function and Regulation

What monomeric nucleotide binding domains can teach us about dimeric ABC proteins

Functional modulation of chemical mediators in microbial communities

Methionine in a protein hydrophobic core drives tight interactions required for assembly of spider silk

Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes

Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases-Studies on Inhibition Mechanism and Kinetics

The incredible diversity of structures and functions of ABC transporters

Trapping of a Polyketide Synthase Module after C−C Bond Formation Reveals Transient Acyl Carrier Domain Interactions

Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense

Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli

Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis

Proline-Based Allosteric Inhibitors of Zika and Dengue Virus NS2B/NS3 Proteases

Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity

New peptidomimetic rhodesain inhibitors with improved selectivity towards human cathepsins

Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function

Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP 2

New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the Trypanosoma Protease Rhodesain

[4.3.1] Bicyclic FKBP ligands inhibit Legionella pneumophila infection by LpMip-dependent and LpMip independent mechanisms

Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP2

Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure–Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies

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