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Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions

mAbs, 2024, Vol.16 (1), p.2341443-2341443

2024

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Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium

American journal of respiratory cell and molecular biology, 2011-03, Vol.44 (3), p.276-284

2011

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Nanobodies and their Use in GPCR Drug Discovery

Current topics in medicinal chemistry, 2015-01, Vol.15 (24), p.2543-2557

2015

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Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A‐mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

British journal of pharmacology, 2002-06, Vol.136 (3), p.421-433

2002

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Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats

Neuropharmacology, 2005, Vol.49, p.167-178

2005

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Regulation of Neuregulin 1β1–Induced MUC5AC and MUC5B Expression in Human Airway Epithelium

American journal of respiratory cell and molecular biology, 2010-04, Vol.42 (4), p.472-481

2010

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Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers

American journal of physiology. Lung cellular and molecular physiology, 2004-08, Vol.287 (2), p.L332-L343

2004

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Nanobodies® as inhaled biotherapeutics for lung diseases

Pharmacology & therapeutics (Oxford), 2017-01, Vol.169, p.47-56

2017

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RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells

The Journal of biological chemistry, 2005-09, Vol.280 (39), p.33178-33189

2005

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Treatment with Anti–Gremlin 1 Antibody Ameliorates Chronic Hypoxia/SU5416–Induced Pulmonary Arterial Hypertension in Mice

The American journal of pathology, 2013-11, Vol.183 (5), p.1461-1473

2013

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Nanobodies® † †Nanobody is a registered trademark of Ablynx NV. as inhaled biotherapeutics for lung diseases

Pharmacology & therapeutics (Oxford), 2017-01, Vol.169, p.47-56

2017

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Cyclic AMP-dependent Transcriptional Up-regulation of Phosphodiesterase 4D5 in Human Airway Smooth Muscle Cells

The Journal of biological chemistry, 2002-09, Vol.277 (39), p.35980-35989

2002

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Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropion

Drug Discovery Today, 2003-11, Vol.8 (22), p.1025-1034

2003

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In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

Cellular signalling, 2005-09, Vol.17 (9), p.1158-1173

2005

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Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter

The Journal of biological chemistry, 2002-09, Vol.277 (39), p.35980-35989

2002

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Regulation of Neuregulin 1[beta]1-Induced MUC5AC and MUC5B Expression in Human Airway Epithelium

American journal of respiratory cell and molecular biology, 2010-04, Vol.42 (4), p.472

2010

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High-level expression of human asparagine synthetase and production of monoclonal antibodies for enzyme purification

Protein expression and purification, 1992-08, Vol.3 (4), p.337-346

1992

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Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene

Biochemical journal, 2004-06, Vol.380 (Pt 2), p.371-384

2004

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RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with Î²Arrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the Î²2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells

The Journal of biological chemistry, 2005-09, Vol.280 (39), p.33178

2005

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RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells

The Journal of biological chemistry, 2005-09, Vol.280 (39), p.33178-33189

2005

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RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with beta Arrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the beta sub(2)-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells

The Journal of biological chemistry, 2005-09, Vol.280 (39), p.33178-33189

2005

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Histidine-49 is necessary for the pH-dependent transition between active and inactive states of the bovine F1-ATPase inhibitor protein

Biochimica et biophysica acta, Protein structure and molecular enzymology, 1996-02, Vol.1292 (2), p.241-248

1996

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Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers

American journal of physiology. Lung cellular and molecular physiology, 2004-08, Vol.31 (2), p.L332-L343

2004

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Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium

American journal of respiratory cell and molecular biology, 2010-04, Vol.42 (4), p.472-481

2010

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High yield expression and secretion of the ovine pregnancy recognition hormone interferon-tau by Pichia pastoris

Journal of interferon & cytokine research, 1996-02, Vol.16 (2), p.119-126

1996

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Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions

Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium

Nanobodies and their Use in GPCR Drug Discovery

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A‐mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats

Regulation of Neuregulin 1β1–Induced MUC5AC and MUC5B Expression in Human Airway Epithelium

Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers

Nanobodies® as inhaled biotherapeutics for lung diseases

RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells

Treatment with Anti–Gremlin 1 Antibody Ameliorates Chronic Hypoxia/SU5416–Induced Pulmonary Arterial Hypertension in Mice

Nanobodies® † †Nanobody is a registered trademark of Ablynx NV. as inhaled biotherapeutics for lung diseases

Cyclic AMP-dependent Transcriptional Up-regulation of Phosphodiesterase 4D5 in Human Airway Smooth Muscle Cells

Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropion

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter

Regulation of Neuregulin 1[beta]1-Induced MUC5AC and MUC5B Expression in Human Airway Epithelium

High-level expression of human asparagine synthetase and production of monoclonal antibodies for enzyme purification

Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene

RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with Î²Arrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the Î²2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells

RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with beta Arrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the beta sub(2)-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells

Histidine-49 is necessary for the pH-dependent transition between active and inactive states of the bovine F1-ATPase inhibitor protein

Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers

Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium

High yield expression and secretion of the ovine pregnancy recognition hormone interferon-tau by Pichia pastoris

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