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A Simple, High-Resolution Method for Establishing DNA Binding Affinity and Sequence Selectivity

Journal of the American Chemical Society, 2001-06, Vol.123 (25), p.5878-5891

2001

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Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein

SLAS discovery, 2022-12, Vol.27 (8), p.448-459

2022

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β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

Cell, 2020-06, Vol.181 (6), p.1364-1379.e14

2020

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Exceptionally Potent Inhibitors of Fatty Acid Amide Hydrolase: The Enzyme Responsible for Degradation of Endogenous Oleamide and Anandamide

Proceedings of the National Academy of Sciences - PNAS, 2000-05, Vol.97 (10), p.5044-5049

2000

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Combination Treatment of the Oral CHK1 Inhibitor, SRA737, and Low-Dose Gemcitabine Enhances the Effect of Programmed Death Ligand 1 Blockade by Modulating the Immune Microenvironment in SCLC

Journal of thoracic oncology, 2019-12, Vol.14 (12), p.2152-2163

2019

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Total Synthesis of Ningalin B Utilizing a Heterocyclic Azadiene Diels−Alder Reaction and Discovery of a New Class of Potent Multidrug Resistant (MDR) Reversal Agents

Journal of organic chemistry, 2000-04, Vol.65 (8), p.2479-2483

2000

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Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase

Journal of medicinal chemistry, 2021-05, Vol.64 (9), p.5645-5653

2021

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An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase

Antimicrobial agents and chemotherapy, 2022-04, Vol.66 (4), p.e0210921-e0210921

2022

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Evidence That the DNA Endonuclease ARTEMIS also Has Intrinsic 5′-Exonuclease Activity

The Journal of biological chemistry, 2014-03, Vol.289 (11), p.7825-7834

2014

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Discovery of β‑Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.8357-8363

2019

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Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase

Nature chemical biology, 2017-06, Vol.13 (6), p.624

2017

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Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

ChemMedChem, 2015-10, Vol.10 (10), p.1655-1671

2015

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N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

ChemMedChem, 2016-02, Vol.11 (3), p.283-288

2016

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Discovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1849-1856

2005

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ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse

ACS chemical biology, 2016-07, Vol.11 (7), p.1880-1890

2016

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Connecting proteins with drug-like compounds: Open source drug discovery workflows with BindingDB and KNIME

Database : the journal of biological databases and curation, 2015, Vol.2015, p.bav087

2015

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Total Synthesis of Distamycin A and 2640 Analogues: A Solution-Phase Combinatorial Approach to the Discovery of New, Bioactive DNA Binding Agents and Development of a Rapid, High-Throughput Screen for Determining Relative DNA Binding Affinity or DNA Binding Sequence Selectivity

Journal of the American Chemical Society, 2000-07, Vol.122 (27), p.6382-6394

2000

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Discovery of a Plasmodium falciparum Glucose-6-phosphate Dehydrogenase 6‑phosphogluconolactonase Inhibitor (R,Z)‑N‑((1-Ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro‑2H‑benzo[b][1,4]thiazine-6-carboxamide (ML276) That Reduces Parasite Growth in Vitro

Journal of medicinal chemistry, 2012-08, Vol.55 (16), p.7262-7272

2012

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Imidazole-derived agonists for the neurotensin 1 receptor

Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (1), p.262-267

2014

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Discovery of ML314, a Brain Penetrant Nonpeptidic β‑Arrestin Biased Agonist of the Neurotensin NTR1 Receptor

ACS medicinal chemistry letters, 2013-09, Vol.4 (9), p.846-851

2013

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Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy

ACS chemical neuroscience, 2012-03, Vol.3 (3), p.221-236

2012

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Total Syntheses of Thiocoraline and BE-22179 and Assessment of Their DNA Binding and Biological Properties

Journal of the American Chemical Society, 2001-01, Vol.123 (4), p.561-568

2001

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α-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and α-substitution

Bioorganic & medicinal chemistry letters, 2001-06, Vol.11 (12), p.1517-1520

2001

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Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems

The Journal of pharmacology and experimental therapeutics, 2001-10, Vol.299 (1), p.332

2001

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Multidrug resistance reversal activity of key ningalin analogues

Bioorganic & medicinal chemistry letters, 2003-05, Vol.13 (10), p.1777-1781

2003

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A Simple, High-Resolution Method for Establishing DNA Binding Affinity and Sequence Selectivity

Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein

β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

Exceptionally Potent Inhibitors of Fatty Acid Amide Hydrolase: The Enzyme Responsible for Degradation of Endogenous Oleamide and Anandamide

Combination Treatment of the Oral CHK1 Inhibitor, SRA737, and Low-Dose Gemcitabine Enhances the Effect of Programmed Death Ligand 1 Blockade by Modulating the Immune Microenvironment in SCLC

Total Synthesis of Ningalin B Utilizing a Heterocyclic Azadiene Diels−Alder Reaction and Discovery of a New Class of Potent Multidrug Resistant (MDR) Reversal Agents

Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase

An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase

Evidence That the DNA Endonuclease ARTEMIS also Has Intrinsic 5′-Exonuclease Activity

Discovery of β‑Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase

Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

Discovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics

ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse

Connecting proteins with drug-like compounds: Open source drug discovery workflows with BindingDB and KNIME

Total Synthesis of Distamycin A and 2640 Analogues: A Solution-Phase Combinatorial Approach to the Discovery of New, Bioactive DNA Binding Agents and Development of a Rapid, High-Throughput Screen for Determining Relative DNA Binding Affinity or DNA Binding Sequence Selectivity

Discovery of a Plasmodium falciparum Glucose-6-phosphate Dehydrogenase 6‑phosphogluconolactonase Inhibitor (R,Z)‑N‑((1-Ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro‑2H‑benzo[b][1,4]thiazine-6-carboxamide (ML276) That Reduces Parasite Growth in Vitro

Imidazole-derived agonists for the neurotensin 1 receptor

Discovery of ML314, a Brain Penetrant Nonpeptidic β‑Arrestin Biased Agonist of the Neurotensin NTR1 Receptor

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy

Total Syntheses of Thiocoraline and BE-22179 and Assessment of Their DNA Binding and Biological Properties

α-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and α-substitution

Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems

Multidrug resistance reversal activity of key ningalin analogues

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