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Phospholipids and Alzheimer's disease: alterations, mechanisms and potential biomarkers

International Journal of Molecular Sciences, 2013-01, Vol.14 (1), p.1310-1322

2013

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Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

Nature communications, 2021-02, Vol.12 (1), p.1158-1158, Article 1158

2021

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Bidirectional links between Alzheimer's disease and Niemann–Pick type C disease

Neurobiology of disease, 2014-12, Vol.72, p.37-47

2014

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Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

PloS one, 2016-11, Vol.11 (11), p.e0167428-e0167428

2016

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N-glycome of the Lysosomal Glycocalyx is Altered in Niemann-Pick Type C Disease (NPC) Model Cells

Molecular & cellular proteomics, 2018-04, Vol.17 (4), p.631-642

2018

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Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts

Biochemical and biophysical research communications, 2010-03, Vol.393 (3), p.404-409

2010

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Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation

International journal of molecular sciences, 2021-12, Vol.22 (24), p.13256

2021

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Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C

Frontiers in cellular neuroscience, 2021-10, Vol.15, p.757482-757482

2021

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Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders

Biomedicines, 2023-10, Vol.11 (10), p.2793

2023

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BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains

PloS one, 2018-07, Vol.13 (7), p.e0200344-e0200344

2018

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A Presenilin Dimer at the Core of the γ-Secretase Enzyme: Insights from Parallel Analysis of Notch 1 and APP Proteolysis

Proceedings of the National Academy of Sciences - PNAS, 2003-10, Vol.100 (22), p.13075-13080

2003

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Emerging Trends in the Field of Inflammation and Proteinopathy in ALS/FTD Spectrum Disorder

Biomedicines, 2023-05, Vol.11 (6), p.1599

2023

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Synthesis of new 2-aminoimidazolones with antiproliferative activity via base promoted amino-β-lactam rearrangement

Tetrahedron, 2015-12, Vol.71 (49), p.9202-9215

2015

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Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors

European journal of medicinal chemistry, 2014-11, Vol.87, p.722-734

2014

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Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors

Bioorganic & medicinal chemistry, 2015-05, Vol.23 (10), p.2353-2359

2015

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Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation

Neuroscience letters, 2011-01, Vol.487 (3), p.287-292

2011

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Mutations in APP have independent effects on Aβ and CTFγ generation

Neurobiology of disease, 2004-11, Vol.17 (2), p.205-218

2004

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Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes

Neurobiology of disease, 2004-04, Vol.15 (3), p.654-666

2004

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Pharmacological activation of LXRs decreases amyloid-β levels in Niemann-Pick type C model cells

Current pharmaceutical biotechnology, 2013-07, Vol.14 (6), p.582-593

2013

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Enhanced activity of superoxide dismutase is a common response to dietary and genetically induced increased cholesterol levels

Nutritional neuroscience, 2020-05, Vol.23 (5), p.398-410

2020

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GSK-3-TSC axis governs lysosomal acidification through autophagy and endocytic pathways

Cellular signalling, 2020-07, Vol.71, p.109597-109597, Article 109597

2020

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Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6L

Mechanisms of ageing and development, 2022-10, Vol.207, p.111726-111726, Article 111726

2022

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Phospholipids and Alzheimer #8217;s Disease: Alterations, Mechanisms and Potential Biomarkers

International journal of molecular sciences, 2013-01, Vol.14 (1), p.1310-1322

2013

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Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : A cross-sectional study

Journal of neurology, 2007-12, Vol.254 (12), p.1676-1683

2007

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GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells

Biochemical and biophysical research communications, 2014-07, Vol.450 (1), p.160-165

2014

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Phospholipids and Alzheimer's disease: alterations, mechanisms and potential biomarkers

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

Bidirectional links between Alzheimer's disease and Niemann–Pick type C disease

Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

N-glycome of the Lysosomal Glycocalyx is Altered in Niemann-Pick Type C Disease (NPC) Model Cells

Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts

Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation

Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C

Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders

BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains

A Presenilin Dimer at the Core of the γ-Secretase Enzyme: Insights from Parallel Analysis of Notch 1 and APP Proteolysis

Emerging Trends in the Field of Inflammation and Proteinopathy in ALS/FTD Spectrum Disorder

Synthesis of new 2-aminoimidazolones with antiproliferative activity via base promoted amino-β-lactam rearrangement

Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors

Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors

Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation

Mutations in APP have independent effects on Aβ and CTFγ generation

Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes

Pharmacological activation of LXRs decreases amyloid-β levels in Niemann-Pick type C model cells

Enhanced activity of superoxide dismutase is a common response to dietary and genetically induced increased cholesterol levels

GSK-3-TSC axis governs lysosomal acidification through autophagy and endocytic pathways

Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6L

Phospholipids and Alzheimer #8217;s Disease: Alterations, Mechanisms and Potential Biomarkers

Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : A cross-sectional study

GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells

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