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Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers

PLoS biology, 2021-02, Vol.19 (2), p.e3001138-e3001138

2021

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In silico RNA isoform screening to identify potential cancer driver exons with therapeutic applications

Nature communications, 2024-08, Vol.15 (1), p.7039-19

2024

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robustica: customizable robust independent component analysis

BMC bioinformatics, 2022-12, Vol.23 (1), p.519-9, Article 519

2022

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Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells

Proceedings of the National Academy of Sciences - PNAS, 2015-12, Vol.112 (52), p.E7276-E7285

2015

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Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth

Cancer letters, 2017-11, Vol.409, p.91-103

2017

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Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis

ACS chemical biology, 2017-01, Vol.12 (1), p.174-182

2017

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Modulation of the Endomembrane System by the Anticancer Natural Product Superstolide/ZJ-101

International journal of molecular sciences, 2023-05, Vol.24 (11), p.9575

2023

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Comparison of dose selection based on target engagement versus inhibition of receptor–ligand interaction for checkpoint inhibitors

CPT: pharmacometrics and systems pharmacology, 2024-06, Vol.13 (6), p.919-925

2024

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Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole

Clinical cancer research, 2016-06, Vol.22 (11), p.2709-2720

2016

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Insights into the structure–activity relationship of the anticancer compound ZJ-101: A role played by the amide moiety

Bioorganic & medicinal chemistry letters, 2024-06, Vol.105, p.129741-129741, Article 129741

2024

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Synthesis and biological evaluation of biotinylated ZJ-101

Bioorganic & medicinal chemistry letters, 2023-07, Vol.91, p.129372-129372, Article 129372

2023

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Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation

Angewandte Chemie (International ed.), 2016-09, Vol.55 (39), p.12035-12039

International ed. in English, 2016

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ProteinFishing: a protein complex generator within the ModelX toolsuite

Bioinformatics, 2020-08, Vol.36 (14), p.4208-4210

2020

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Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition

Journal of medicinal chemistry, 2018-12, Vol.61 (24), p.11158-11168

2018

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Specialization of the photoreceptor transcriptome by Srrm3 -dependent microexons is required for outer segment maintenance and vision

Proceedings of the National Academy of Sciences - PNAS, 2022-07, Vol.119 (29), p.e2117090119

2022

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Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein

Cell reports (Cambridge), 2015-02, Vol.10 (4), p.600-615

2015

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Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism

Cancer letters, 2015-06, Vol.362 (1), p.106-115

2015

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Insights into the structure–activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A role played by the lactone moiety

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (19), p.4702-4704

2016

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Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP)

Antiviral research, 2018-08, Vol.156, p.55-63

2018

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Insights into the structure–activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A critical role played by the conjugated trienyl lactone moiety

Bioorganic & medicinal chemistry letters, 2016-08, Vol.26 (15), p.3411-3413

2016

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Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking

International journal of biological sciences, 2018-01, Vol.14 (10), p.1175-1185

2018

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Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors

ACS medicinal chemistry letters, 2020-06, Vol.11 (6), p.1111-1117

2020

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Insights into the structure–activity relationship of the anticancer compound ZJ-101: A critical role played by the cyclohexene ring

Bioorganic & medicinal chemistry letters, 2016-06, Vol.26 (12), p.2890-2892

2016

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Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

Journal of visualized experiments, 2016-09 (115)

2016

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Clofoctol and sorafenib inhibit prostate cancer growth via synergistic induction of endoplasmic reticulum stress and UPR pathways

Cancer management and research, 2018-01, Vol.10, p.4817-4829

2018

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Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers

In silico RNA isoform screening to identify potential cancer driver exons with therapeutic applications

robustica: customizable robust independent component analysis

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells

Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis

Modulation of the Endomembrane System by the Anticancer Natural Product Superstolide/ZJ-101

Comparison of dose selection based on target engagement versus inhibition of receptor–ligand interaction for checkpoint inhibitors

Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole

Insights into the structure–activity relationship of the anticancer compound ZJ-101: A role played by the amide moiety

Synthesis and biological evaluation of biotinylated ZJ-101

Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation

ProteinFishing: a protein complex generator within the ModelX toolsuite

Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition

Specialization of the photoreceptor transcriptome by Srrm3 -dependent microexons is required for outer segment maintenance and vision

Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein

Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism

Insights into the structure–activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A role played by the lactone moiety

Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP)

Insights into the structure–activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A critical role played by the conjugated trienyl lactone moiety

Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking

Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors

Insights into the structure–activity relationship of the anticancer compound ZJ-101: A critical role played by the cyclohexene ring

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

Clofoctol and sorafenib inhibit prostate cancer growth via synergistic induction of endoplasmic reticulum stress and UPR pathways

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