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Analysis of binding site for the novel small‐molecule TLR4 signal transduction inhibitor TAK‐242 and its therapeutic effect on mouse sepsis model

British journal of pharmacology, 2009-08, Vol.157 (7), p.1250-1262

2009

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Role of Phosphoinositide 3-Kinase in Innate Immunity

Biological and Pharmaceutical Bulletin, 2007/09/01, Vol.30(9), pp.1617-1623

2007

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Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling

The Journal of biological chemistry, 1994-09, Vol.269 (36), p.22732-22737

1994

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Negative Regulation of Class IA Phosphoinositide 3-kinase by Protein Kinase C Limits Fc Receptor-Mediated Phagocytosis in Macrophages

Journal of biochemistry (Tokyo), 2008-10, Vol.145 (1), p.87-94

2008

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A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

Molecular pharmacology, 2006-04, Vol.69 (4), p.1288-1295

2006

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PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel

Journal of biochemistry (Tokyo), 2019-01, Vol.165 (1), p.75

2019

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Functional Modulation of Human Macrophages Through CD46 (Measles Virus Receptor): Production of IL-12 p40 and Nitric Oxide in Association with Recruitment of Protein-Tyrosine Phosphatase SHP-1 to CD46

The Journal of immunology (1950), 2000-11, Vol.165 (9), p.5143-5152

2000

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IRAK-4-dependent Degradation of IRAK-1 is a Negative Feedback Signal for TLR-mediated NF- B Activation

Journal of biochemistry (Tokyo), 2007-12, Vol.143 (3), p.295-302

2007

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C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase

Journal of biochemistry (Tokyo), 2011-03, Vol.149 (3), p.265-274

2011

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Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

Trends in Biochemical Sciences, 1995-08, Vol.20 (8), p.303-307

1995

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Opposite Effects of Wortmannin and 2-(4-Morpholinyl)-8-phenyl-1(4 H )-benzopyran-4-one Hydrochloride on Toll-Like Receptor-Mediated Nitric Oxide Production: Negative Regulation of Nuclear Factor-κB by Phosphoinositide 3-Kinase

Molecular pharmacology, 2006-05, Vol.69 (5), p.1717-1724

2006

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Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis

International immunopharmacology, 2002-03, Vol.2 (4), p.423-434

2002

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Toll‐like receptor‐mediated tyrosine phosphorylation of paxillin via MyD88‐dependent and ‐independent pathways

European journal of immunology, 2003-03, Vol.33 (3), p.740-747

2003

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Involvement of Phosphoinositide 3-Kinase in Regulation of Adhesive Activity of Highly Metastatic Hepatoma Cells

Journal of biochemistry (Tokyo), 1998-11, Vol.124 (5), p.1020-1025

1998

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Permissive effect of ceramide on growth factor-induced cell proliferation

Biochemical journal, 1995-11, Vol.311 ( Pt 3) (3), p.829-834

1995

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Participation of a MEK-independent pathway in MAP kinase activation and modulation of cell growth in mouse hepatoma cell lines

International journal of molecular medicine, 2000-08, Vol.6 (2), p.155

2000

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Inhibition of lipid A-mediated type I interferon induction by Bactericidal/permeability-increasing protein (BPI)

Biochemical and biophysical research communications, 2007-03, Vol.354 (2), p.574-578

2007

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Enhancement of chemotactic peptide-induced activation of phosphoinositide 3-kinase by granulocyte-macrophage colony-stimulating factor and its relation to the cytokine-mediated priming of neutrophil superoxide-anion production

Biochemical journal, 1999-01, Vol.337 ( Pt 2) (2), p.201-209

1999

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The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase

The Journal of biological chemistry, 2000-01, Vol.275 (1), p.414-422

2000

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Protein tyrosine phosphorylation induced by monoclonal antibodies against MCP (CD46)

Molecular immunology, 1993-09, Vol.30, p.14-14

1993

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Cyclic AMP-increasing Agents Interfere with Chemoattractant-induced Respiratory Burst in Neutrophils as a Result of the Inhibition of Phosphatidylinositol 3-Kinase Rather than Receptor-operated Ca2+ Influx (∗)

The Journal of biological chemistry, 1995-10, Vol.270 (40), p.23816-23822

1995

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Specific association of phosphatidylinositol 3-kinase with the protooncogene product Cbl in Fcγ receptor signaling

FEBS letters, 1996-03, Vol.382 (1), p.11-14

1996

Volltextzugriff (PDF)

Molecular assembly of CD46 with CD9, alpha3–beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF

Molecular immunology, 2002-02, Vol.38 (9), p.689-700

2002

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Cotylenin A, a Plant-Growth Regulator, Induces the Differentiation in Murine and Human Myeloid Leukemia Cells

Biochemical and biophysical research communications, 1997-09, Vol.238 (3), p.758-763

1997

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Activation of phosphatidylinositol 3-kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related, and an essential role of the G-protein-coupled signals for the lectin-induced respiratory burst in human monocytic THP-1 cells

Biochemical journal, 1996-04, Vol.315 ( Pt 2) (2), p.505-512

1996

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Analysis of binding site for the novel small‐molecule TLR4 signal transduction inhibitor TAK‐242 and its therapeutic effect on mouse sepsis model

Role of Phosphoinositide 3-Kinase in Innate Immunity

Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling

Negative Regulation of Class IA Phosphoinositide 3-kinase by Protein Kinase C Limits Fc Receptor-Mediated Phagocytosis in Macrophages

A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel

Functional Modulation of Human Macrophages Through CD46 (Measles Virus Receptor): Production of IL-12 p40 and Nitric Oxide in Association with Recruitment of Protein-Tyrosine Phosphatase SHP-1 to CD46

IRAK-4-dependent Degradation of IRAK-1 is a Negative Feedback Signal for TLR-mediated NF- B Activation

C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

Opposite Effects of Wortmannin and 2-(4-Morpholinyl)-8-phenyl-1(4 H )-benzopyran-4-one Hydrochloride on Toll-Like Receptor-Mediated Nitric Oxide Production: Negative Regulation of Nuclear Factor-κB by Phosphoinositide 3-Kinase

Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis

Toll‐like receptor‐mediated tyrosine phosphorylation of paxillin via MyD88‐dependent and ‐independent pathways

Involvement of Phosphoinositide 3-Kinase in Regulation of Adhesive Activity of Highly Metastatic Hepatoma Cells

Permissive effect of ceramide on growth factor-induced cell proliferation

Participation of a MEK-independent pathway in MAP kinase activation and modulation of cell growth in mouse hepatoma cell lines

Inhibition of lipid A-mediated type I interferon induction by Bactericidal/permeability-increasing protein (BPI)

Enhancement of chemotactic peptide-induced activation of phosphoinositide 3-kinase by granulocyte-macrophage colony-stimulating factor and its relation to the cytokine-mediated priming of neutrophil superoxide-anion production

The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase

Protein tyrosine phosphorylation induced by monoclonal antibodies against MCP (CD46)

Cyclic AMP-increasing Agents Interfere with Chemoattractant-induced Respiratory Burst in Neutrophils as a Result of the Inhibition of Phosphatidylinositol 3-Kinase Rather than Receptor-operated Ca2+ Influx (∗)

Specific association of phosphatidylinositol 3-kinase with the protooncogene product Cbl in Fcγ receptor signaling

Molecular assembly of CD46 with CD9, alpha3–beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF

Cotylenin A, a Plant-Growth Regulator, Induces the Differentiation in Murine and Human Myeloid Leukemia Cells

Activation of phosphatidylinositol 3-kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related, and an essential role of the G-protein-coupled signals for the lectin-induced respiratory burst in human monocytic THP-1 cells

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