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Hsp90, an unlikely ally in the war on cancer

The FEBS journal, 2013-03, Vol.280 (6), p.1381-1396

2013

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Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2+ Breast Cancer

Cell chemical biology, 2016-06, Vol.23 (6), p.678-688

2016

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Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice

Arthritis research & therapy, 2019-12, Vol.21 (1), p.292-292, Article 292

2019

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Molecular Biologist's Guide to Proteomics

Microbiology and Molecular Biology Reviews, 2002-03, Vol.66 (1), p.39-63

2002

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Death‐associated protein kinase 3 regulates the myogenic reactivity of cerebral arteries

Experimental physiology, 2023-07, Vol.108 (7), p.986-997

2023

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An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target

Antiviral research, 2016-06, Vol.130, p.81-92

2016

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Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease

Cell chemical biology, 2017-08, Vol.24 (8), p.1029-1039.e7

2017

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Expression of membrane Hsp90 is a molecular signature of T cell activation

Scientific reports, 2022-10, Vol.12 (1), p.18091-18091, Article 18091

2022

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TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases

Open biology, 2020-09, Vol.10 (9), p.200099-200099

2020

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A bioorthogonal chemical reporter for fatty acid synthase–dependent protein acylation

The Journal of biological chemistry, 2021-11, Vol.297 (5), p.101272-101272, Article 101272

2021

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A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle

Molecular pharmacology, 2016-01, Vol.89 (1), p.105-117

2016

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A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo

ACS chemical biology, 2017-04, Vol.12 (4), p.1047-1055

2017

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Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion

Scientific reports, 2018-11, Vol.8 (1), p.17058-11, Article 17058

2018

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Near-simultaneous intravital microscopy of glucose uptake and mitochondrial membrane potential, key endpoints that reflect major metabolic axes in cancer

Scientific reports, 2017-10, Vol.7 (1), p.13772-15, Article 13772

2017

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A highly selective inhibitor of interleukin-1 receptor–associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase

The Journal of biological chemistry, 2020-02, Vol.295 (6), p.1565-1574

2020

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Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome

Cell chemical biology, 2024-04, Vol.31 (4), p.729-742.e13

2024

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Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

Cell stress & chaperones, 2018-07, Vol.23 (4), p.467-482

2018

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Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development

Cell chemical biology, 2024-03, Vol.31 (3), p.465-476.e12

2024

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The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules

The Journal of cell biology, 2013-12, Vol.203 (5), p.737-746

2013

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Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Do Not Influence Aortic Remodeling in Hypertension

Hypertension (Dallas, Tex. 1979), 2011-03, Vol.57 (3, Part 2 Suppl), p.577-585

2011

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Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity

Oncotarget, 2017-02, Vol.8 (6), p.10425-10436

2017

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Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling

Scientific reports, 2019-01, Vol.9 (1), p.481-481, Article 481

2019

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Application of immobilized ATP to the study of NLRP inflammasomes

Archives of biochemistry and biophysics, 2019-07, Vol.670, p.104-115

2019

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Mechanisms by which smoothelin-like protein 1 reverses insulin resistance in myotubules and mice

Molecular and cellular endocrinology, 2022-07, Vol.551, p.111663-111663, Article 111663

2022

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ROCK1 Phosphorylates and Activates Zipper-interacting Protein Kinase

The Journal of biological chemistry, 2007-02, Vol.282 (7), p.4884-4893

2007

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Hsp90, an unlikely ally in the war on cancer

Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2+ Breast Cancer

Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice

Molecular Biologist's Guide to Proteomics

Death‐associated protein kinase 3 regulates the myogenic reactivity of cerebral arteries

An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target

Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease

Expression of membrane Hsp90 is a molecular signature of T cell activation

TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases

A bioorthogonal chemical reporter for fatty acid synthase–dependent protein acylation

A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle

A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo

Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion

Near-simultaneous intravital microscopy of glucose uptake and mitochondrial membrane potential, key endpoints that reflect major metabolic axes in cancer

A highly selective inhibitor of interleukin-1 receptor–associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase

Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome

Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development

The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules

Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Do Not Influence Aortic Remodeling in Hypertension

Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity

Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling

Application of immobilized ATP to the study of NLRP inflammasomes

Mechanisms by which smoothelin-like protein 1 reverses insulin resistance in myotubules and mice

ROCK1 Phosphorylates and Activates Zipper-interacting Protein Kinase

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