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Neuronal nicotinic acetylcholine receptors - targets for the development of drugs to treat cognitive impairment associated with schizophrenia and Alzheimer's disease

Current topics in medicinal chemistry, 2010-02, Vol.10 (2), p.144-152

2010

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Discovery of a Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonist Series and Characterization of the Potent, Selective, and Orally Efficacious Agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic Acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] Amide (SEN15924, WAY-361789)

Journal of medicinal chemistry, 2012-05, Vol.55 (10), p.4806-4823

2012

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SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist

Bioorganic & medicinal chemistry, 2009-07, Vol.17 (14), p.5247-5258

2009

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N‑[5-(5-Fluoropyridin-3-yl)‑1H‑pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.10277-10281

2012

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5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT6 Receptor Antagonists

Journal of medicinal chemistry, 2010-03, Vol.53 (6), p.2521-2527

2010

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1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT6 receptor ligands

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (24), p.6935-6938

2009

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Novel Oxidation of Cyclosporin A: Preparation of Cyclosporin Methyl Vinyl Ketone (Cs-MVK)

Synlett, 2009-11, Vol.2009 (18), p.2935-2938

2009

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PS-073-Preclinical profile of HBV core protein inhibitor, ABI-H, a potent inhibitor of cccDNA generation in HBV infected cells

Journal of hepatology, 2019-04, Vol.70 (1), p.e48-e48

2019

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Procognitive and Neuroprotective Activity of a Novel α7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders

The Journal of pharmacology and experimental therapeutics, 2009-05, Vol.329 (2), p.459-468

2009

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Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor

European journal of medicinal chemistry, 2014-05, Vol.78, p.401-418

2014

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Synthesis of Novel 4-Fluoro-2H-pyrazol-3-ylamines

Synthetic communications, 2010-08, Vol.40 (17), p.2547-2555

2010

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Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625

Psychopharmacologia, 2011-12, Vol.218 (4), p.635-647

2011

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Synthesis and antitumor activities of 5-methyl-1- and 2-[[2-dimethylaminoethyl]amino]-aza-thiopyranoindazoles

Bioorganic & medicinal chemistry letters, 2000-02, Vol.10 (3), p.305-308

2000

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Heterobiaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part II

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6613-6617

2009

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5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT 6 Receptor Antagonists

Journal of medicinal chemistry, 2010-03, Vol.53 (6), p.2521-2527

2010

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1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT sub(6) receptor ligands

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (24), p.6935-6938

2009

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Corrigendum to “SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist” [Bioorg. Med. Chem. 17 (2009) 5247]

Bioorganic & medicinal chemistry, 2010, Vol.18 (2), p.985-985

2010

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PRE-CLINICAL CHARACTERIZATION OF THE ALPHA-7 NICOTINIC RECEPTOR AGONIST SEN12333/WAY-317538

Schizophrenia research, 2008, Vol.102 (1), p.262-262

2008

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P3‐329: SAM‐531, N,N‐dimethyl‐3‐{[3‐(1‐naphthylsulfonyl)‐1H‐indazol‐5‐yl]oxy} propan‐1‐amine, a novel serotonin‐6 receptor antagonist with preclinical pro‐cognitive efficacy

Alzheimer's & dementia, 2010-07, Vol.6 (4S_Part_18), p.S548-S549

2010

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SAM-531, N,N-dimethyl-3-{[3-(1-naphthylsulfonyl)-1H-indazol-5-yl]oxy} propan-1-amine, a novel serotonin-6 receptor antagonist with preclinical pro-cognitive efficacy

Alzheimer's & dementia, 2010-07, Vol.6 (4), p.S548-S549

2010

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1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (24), p.6935-6938

2009

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Synthesis of regioisomeric 2,5-bis-substituted-aza-benzothiopyranoindazoles

Journal of heterocyclic chemistry, 2001-09, Vol.38 (5), p.1153-1166

2001

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Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders

The Journal of pharmacology and experimental therapeutics, 2009-05, Vol.329 (2), p.459

2009

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Neuroprotective Agents for the Treatment of Ischemic and Hemorrhagic Stroke

Annual Reports in Medicinal Chemistry, 2006, Vol.41, p.39-57

2006

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Neuronal nicotinic acetylcholine receptors - targets for the development of drugs to treat cognitive impairment associated with schizophrenia and Alzheimer's disease

Discovery of a Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonist Series and Characterization of the Potent, Selective, and Orally Efficacious Agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic Acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] Amide (SEN15924, WAY-361789)

SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist

N‑[5-(5-Fluoropyridin-3-yl)‑1H‑pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate

Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914)

5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT6 Receptor Antagonists

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT6 receptor ligands

Novel Oxidation of Cyclosporin A: Preparation of Cyclosporin Methyl Vinyl Ketone (Cs-MVK)

PS-073-Preclinical profile of HBV core protein inhibitor, ABI-H, a potent inhibitor of cccDNA generation in HBV infected cells

Procognitive and Neuroprotective Activity of a Novel α7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders

Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor

Synthesis of Novel 4-Fluoro-2H-pyrazol-3-ylamines

Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625

Synthesis and antitumor activities of 5-methyl-1- and 2-[[2-dimethylaminoethyl]amino]-aza-thiopyranoindazoles

Heterobiaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part II

5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT 6 Receptor Antagonists

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT sub(6) receptor ligands

Corrigendum to “SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist” [Bioorg. Med. Chem. 17 (2009) 5247]

PRE-CLINICAL CHARACTERIZATION OF THE ALPHA-7 NICOTINIC RECEPTOR AGONIST SEN12333/WAY-317538

P3‐329: SAM‐531, N,N‐dimethyl‐3‐{[3‐(1‐naphthylsulfonyl)‐1H‐indazol‐5‐yl]oxy} propan‐1‐amine, a novel serotonin‐6 receptor antagonist with preclinical pro‐cognitive efficacy

SAM-531, N,N-dimethyl-3-{[3-(1-naphthylsulfonyl)-1H-indazol-5-yl]oxy} propan-1-amine, a novel serotonin-6 receptor antagonist with preclinical pro-cognitive efficacy

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands

Synthesis of regioisomeric 2,5-bis-substituted-aza-benzothiopyranoindazoles

Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders

Neuroprotective Agents for the Treatment of Ischemic and Hemorrhagic Stroke

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