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Macrofilaricides: An Unmet Medical Need for Filarial Diseases

ACS infectious diseases, 2020-04, Vol.6 (4), p.662-671

Hawryluk, Natalie A

2020

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A New Chiral Rh(II) Catalyst for Enantioselective [2 + 1]-Cycloaddition. Mechanistic Implications and Applications

Journal of the American Chemical Society, 2004-07, Vol.126 (29), p.8916-8918

2004

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Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB

PLoS pathogens, 2020-06, Vol.16 (6), p.e1008567-e1008567

2020

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Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

International journal for parasitology -- drugs and drug resistance, 2022-08, Vol.19, p.89-97

2022

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Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists

ACS medicinal chemistry letters, 2013-04, Vol.4 (4), p.419-422

2013

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Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors

The Journal of pharmacology and experimental therapeutics, 2001-10, Vol.299 (1), p.187

2001

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Formal Synthesis of (±)-Guanacastepene A

Journal of organic chemistry, 2003-02, Vol.68 (3), p.1030-1042

2003

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Synthesis of (−)-Dysiherbaine

Organic letters, 2000-03, Vol.2 (5), p.635-638

2000

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Synthesis of the Hydroazulene Ring System of Guanacastepene

Organic letters, 2001-02, Vol.3 (4), p.569-572

2001

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Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.7137-7141

2010

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Abstract 15822: Cardiac Effects of EDG-7500, a Novel Cardiac Sarcomere Regulator: In vitro and in vivo Evidence for Slowing Isovolumic Contraction and Improved Ventricular Compliance

Circulation (New York, N.Y.), 2023-11, Vol.148 (Suppl_1)

2023

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Abstract 15612: EDG-7500, a Novel Cardiac Sarcomere Regulator That Preserves Intrinsic Myosin-Motor Function, Improves Cardiac Function and Reserve in a Minipig Model of Hypertrophic Cardiomyopathy

Circulation (New York, N.Y.), 2023-11, Vol.148 (Suppl_1)

2023

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Dual mTORC1/mTORC2 Inhibition as a Host-Directed Therapeutic Target in Pathologically Distinct Mouse Models of Tuberculosis

Antimicrobial agents and chemotherapy, 2021-06, Vol.65 (7), p.e0025321-e0025321

2021

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1,2-Diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.7142-7146

2010

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EDG-002, A NOVEL TARGETED SARCOMERE REGULATOR PRESERVES INTRINSIC MYOSIN-MOTOR FUNCTION, BLUNTS HYPERCONTRACTILITY AND ELIMINATES LVOT OBSTRUCTION IN CATS WITH HYPERTROPHIC CARDIOMYOPATHY: IN VITRO AND IN VIVO EVIDENCE

Journal of the American College of Cardiology, 2023-03, Vol.81 (8), p.349-349

2023

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Alcohol Inversion Using Cesium Carboxylates and DMAP in Toluene

Journal of organic chemistry, 2000-12, Vol.65 (24), p.8379-8380

2000

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Evidence for dispensability of protein kinase R in host control of tuberculosis

European journal of immunology, 2018-04, Vol.48 (4), p.612-620

2018

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Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections

Journal of medicinal chemistry, 2022-08, Vol.65 (16), p.11388-11403

2022

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Onchocerciasis Drug Discovery

Neglected Tropical Diseases, 2019, p.161-186

2019

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Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis

ACS medicinal chemistry letters, 2018-03, Vol.9 (3), p.210-214

2018

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Complexation-Induced Unfolding of Heterocyclic Ureas. Simple Foldamers Equilibrate with Multiply Hydrogen-Bonded Sheetlike Structures1

Journal of the American Chemical Society, 2001-10, Vol.123 (43), p.10475-10488

2001

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Discovery of a novel series of selective HCN1 blockers

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5197-5201

2011

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Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7357-7362

2012

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1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase

Bioorganic & medicinal chemistry letters, 2014-03, Vol.24 (5), p.1280-1284

2014

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Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structureamutagenicity relationships for arylamine metabolites

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7357-7362

2012

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Macrofilaricides: An Unmet Medical Need for Filarial Diseases

A New Chiral Rh(II) Catalyst for Enantioselective [2 + 1]-Cycloaddition. Mechanistic Implications and Applications

Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists

Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors

Formal Synthesis of (±)-Guanacastepene A

Synthesis of (−)-Dysiherbaine

Synthesis of the Hydroazulene Ring System of Guanacastepene

Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists

Abstract 15822: Cardiac Effects of EDG-7500, a Novel Cardiac Sarcomere Regulator: In vitro and in vivo Evidence for Slowing Isovolumic Contraction and Improved Ventricular Compliance

Abstract 15612: EDG-7500, a Novel Cardiac Sarcomere Regulator That Preserves Intrinsic Myosin-Motor Function, Improves Cardiac Function and Reserve in a Minipig Model of Hypertrophic Cardiomyopathy

Dual mTORC1/mTORC2 Inhibition as a Host-Directed Therapeutic Target in Pathologically Distinct Mouse Models of Tuberculosis

1,2-Diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties

EDG-002, A NOVEL TARGETED SARCOMERE REGULATOR PRESERVES INTRINSIC MYOSIN-MOTOR FUNCTION, BLUNTS HYPERCONTRACTILITY AND ELIMINATES LVOT OBSTRUCTION IN CATS WITH HYPERTROPHIC CARDIOMYOPATHY: IN VITRO AND IN VIVO EVIDENCE

Alcohol Inversion Using Cesium Carboxylates and DMAP in Toluene

Evidence for dispensability of protein kinase R in host control of tuberculosis

Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections

Onchocerciasis Drug Discovery

Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis

Complexation-Induced Unfolding of Heterocyclic Ureas. Simple Foldamers Equilibrate with Multiply Hydrogen-Bonded Sheetlike Structures1

Discovery of a novel series of selective HCN1 blockers

Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites

1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase

Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structureamutagenicity relationships for arylamine metabolites

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