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Recent and Ongoing Research into Metastatic Osteosarcoma Treatments

International journal of molecular sciences, 2022-03, Vol.23 (7), p.3817

2022

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Reconstitution of human pyroptotic cell death in Saccharomyces cerevisiae

Scientific reports, 2023-02, Vol.13 (1), p.3095-3095, Article 3095

2023

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Mutagenic Consequences of Sublethal Cell Death Signaling

International journal of molecular sciences, 2021-06, Vol.22 (11), p.6144

2021

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Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2

Nature structural & molecular biology, 2023-09, Vol.30 (9), p.1265-1274

2023

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Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine

Cell death & disease, 2017-10, Vol.8 (10), p.e3062-e3062

2017

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CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants

Biochemical journal, 2019-05, Vol.476 (9), p.1335-1357

2019

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Osteosarcoma cells depend on MCL-1 for survival, and osteosarcoma metastases respond to MCL-1 antagonism plus regorafenib in vivo

BMC cancer, 2024-11, Vol.24 (1), p.1, Article 1350

2024

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Establishment and Characterisation of Metastatic Extraskeletal Ewing Sarcoma Mouse Models

In vivo (Athens), 2021-11, Vol.35 (6), p.3097-3106

2021

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Mutagenic assessment of chemotherapy and Smac mimetic drugs in cells with defective DNA damage response pathways

Scientific reports, 2018-09, Vol.8 (1), p.14421-14, Article 14421

2018

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Vaccinia Virus Encodes a Novel Inhibitor of Apoptosis That Associates with the Apoptosome

Journal of virology, 2017-12, Vol.91 (23)

2017

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The smac mimetic LCL161 targets established pulmonary osteosarcoma metastases in mice

Clinical & experimental metastasis, 2021-10, Vol.38 (5), p.441-449

2021

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Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly

Cell reports (Cambridge), 2019-11, Vol.29 (7), p.1821-1831.e3

2019

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In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations

Cell death & disease, 2020-08, Vol.11 (8), p.680, Article 680

2020

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Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice

BMC cancer, 2019-09, Vol.19 (1), p.924-18, Article 924

2019

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Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

Proceedings of the National Academy of Sciences - PNAS, 2008-11, Vol.105 (47), p.18081-18087

2008

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Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase/CAD-independent

Apoptosis (London), 2019-06, Vol.24 (5-6), p.404-413

2019

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Mammalian initiator apoptotic caspases

The FEBS journal, 2005-11, Vol.272 (21), p.5436-5453

2005

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TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFα

The Journal of cell biology, 2008-07, Vol.182 (1), p.171-184

2008

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Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic

Apoptosis (London), 2020-08, Vol.25 (7-8), p.500-518

2020

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SfDronc, an initiator caspase involved in apoptosis in the fall armyworm Spodoptera frugiperda

Insect biochemistry and molecular biology, 2013-05, Vol.43 (5), p.444-454

2013

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Tetrazolium reduction assays under-report cell death provoked by clinically relevant concentrations of proteasome inhibitors

Molecular biology reports, 2020-06, Vol.47 (6), p.4849-4856

2020

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The N Terminus of the Vaccinia Virus Protein F1L Is an Intrinsically Unstructured Region That Is Not Involved in Apoptosis Regulation

The Journal of biological chemistry, 2016-07, Vol.291 (28), p.14600-14608

2016

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The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID

Cell, 1999-08, Vol.98 (4), p.453-463

1999

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Modeling Metazoan Apoptotic Pathways in Yeast

Methods in molecular biology (Clifton, N.J.), 2016, Vol.1419, p.161

2016

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Hsp72 Inhibits Apoptosis Upstream of the Mitochondria and Not through Interactions with Apaf-1

The Journal of biological chemistry, 2004-12, Vol.279 (49), p.51490-51499

2004

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Recent and Ongoing Research into Metastatic Osteosarcoma Treatments

Reconstitution of human pyroptotic cell death in Saccharomyces cerevisiae

Mutagenic Consequences of Sublethal Cell Death Signaling

Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2

Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine

CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants

Osteosarcoma cells depend on MCL-1 for survival, and osteosarcoma metastases respond to MCL-1 antagonism plus regorafenib in vivo

Establishment and Characterisation of Metastatic Extraskeletal Ewing Sarcoma Mouse Models

Mutagenic assessment of chemotherapy and Smac mimetic drugs in cells with defective DNA damage response pathways

Vaccinia Virus Encodes a Novel Inhibitor of Apoptosis That Associates with the Apoptosome

The smac mimetic LCL161 targets established pulmonary osteosarcoma metastases in mice

Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly

In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations

Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase/CAD-independent

Mammalian initiator apoptotic caspases

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFα

Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic

SfDronc, an initiator caspase involved in apoptosis in the fall armyworm Spodoptera frugiperda

Tetrazolium reduction assays under-report cell death provoked by clinically relevant concentrations of proteasome inhibitors

The N Terminus of the Vaccinia Virus Protein F1L Is an Intrinsically Unstructured Region That Is Not Involved in Apoptosis Regulation

The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID

Modeling Metazoan Apoptotic Pathways in Yeast

Hsp72 Inhibits Apoptosis Upstream of the Mitochondria and Not through Interactions with Apaf-1

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