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A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction

Molecular cell, 2011-10, Vol.44 (1), p.72-84

2011

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Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

Genes & development, 2011-08, Vol.25 (15), p.1568-1582

2011

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Ribonucleotide Reductase Activity Is Coupled to DNA Synthesis via Proliferating Cell Nuclear Antigen

Current biology, 2012-04, Vol.22 (8), p.720-726

2012

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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)

British journal of haematology, 2014-03, Vol.164 (6), p.811

2014

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Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

Genes & development, 2011-08, Vol.25 (15), p.1568-1582

2011

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CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase

Molecular cell, 2010-10, Vol.40 (1), p.22

2010

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Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

Molecular cell, 2009-07, Vol.35 (1), p.93-104

2009

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Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2

The Journal of biological chemistry, 2012-03, Vol.287 (14), p.11410-11421

2012

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Thymine DNA Glycosylase Is a CRL4Cdt2 Substrate

The Journal of biological chemistry, 2014-08, Vol.289 (33), p.23043-23055

2014

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Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN

British journal of haematology, 2014-03, Vol.164 (6), p.811-821

2014

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Regulation of Late G1/S Phase Transition and APCCdh1 by Reactive Oxygen Species

Molecular and Cellular Biology, 2006-06, Vol.26 (12), p.4701-4711

2006

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Cellular effects of leishmanial tubulin inhibitors on L. donovani

Molecular and biochemical parasitology, 2000-10, Vol.110 (2), p.223-236

2000

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CC-92480, a Novel Cereblon E3 Ligase Modulator, Is Synergistic with Dexamethasone, Bortezomib, and Daratumumab in Multiple Myeloma

Blood, 2019-11, Vol.134 (Supplement_1), p.1815-1815

2019

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CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells

Blood, 2019-11, Vol.134 (Supplement_1), p.1812-1812

2019

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Mechanism of CRL4 Cdt2 , a PCNA-dependent E3 ubiquitin ligase

Genes & development, 2011-08, Vol.25 (15), p.1568-1582

2011

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Abstract 6047: Discovery and characterization of PVTX-321, an estrogen receptor heterobifunctional degrader

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.6047-6047

2024

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CC-122 Has Potent Anti-Lymphoma Activity through Destruction of the Aiolos and Ikaros Transcription Factors and Induction of Interferon Response Pathways

Blood, 2014-12, Vol.124 (21), p.3035-3035

2014

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IMiDs® Immunomodulatory Agents Regulate Interferon-Stimulated Genes through Cereblon-Mediated Aiolos Destruction in Multiple Myeloma (MM) Cells: Identification of a Novel Mechanism of Action and Pathway for Resistance

Blood, 2014-12, Vol.124 (21), p.3432-3432

2014

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Degradation of Aiolos and Ikaros Followed By Downregulation of c-Myc and then IRF4 Leads to Programmed Cell Death in Myeloma Cells Sensitive to IMiDs® Immunomodulatory Compounds

Blood, 2014-12, Vol.124 (21), p.4700-4700

2014

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Ribonucleotide reductase activity is regulated by proliferating cell nuclear antigen (PCNA)

Current biology, 2012-03, Vol.22 (8), p.720-726

2012

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Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors I karos and A iolos via modulation of the E 3 ubiquitin ligase complex CRL 4 CRBN

British journal of haematology, 2014-03, Vol.164 (6), p.811-821

2014

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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4 CRBN

British journal of haematology, 2014, Vol.164 (6), p.811-821

2014

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Single Molecule Studies of Eukaryotic Replisomes in Xenopus Egg Extracts

Biophysical journal, 2010-01, Vol.98 (3), p.437a-437a

2010

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CRL4[super]Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase

Molecular cell, 2010-10, Vol.40 (1), p.22-33

2010

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A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

Ribonucleotide Reductase Activity Is Coupled to DNA Synthesis via Proliferating Cell Nuclear Antigen

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)

Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2

Thymine DNA Glycosylase Is a CRL4Cdt2 Substrate

Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN

Regulation of Late G1/S Phase Transition and APCCdh1 by Reactive Oxygen Species

Cellular effects of leishmanial tubulin inhibitors on L. donovani

CC-92480, a Novel Cereblon E3 Ligase Modulator, Is Synergistic with Dexamethasone, Bortezomib, and Daratumumab in Multiple Myeloma

CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells

Mechanism of CRL4 Cdt2 , a PCNA-dependent E3 ubiquitin ligase

Abstract 6047: Discovery and characterization of PVTX-321, an estrogen receptor heterobifunctional degrader

CC-122 Has Potent Anti-Lymphoma Activity through Destruction of the Aiolos and Ikaros Transcription Factors and Induction of Interferon Response Pathways

IMiDs® Immunomodulatory Agents Regulate Interferon-Stimulated Genes through Cereblon-Mediated Aiolos Destruction in Multiple Myeloma (MM) Cells: Identification of a Novel Mechanism of Action and Pathway for Resistance

Degradation of Aiolos and Ikaros Followed By Downregulation of c-Myc and then IRF4 Leads to Programmed Cell Death in Myeloma Cells Sensitive to IMiDs® Immunomodulatory Compounds

Ribonucleotide reductase activity is regulated by proliferating cell nuclear antigen (PCNA)

Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors I karos and A iolos via modulation of the E 3 ubiquitin ligase complex CRL 4 CRBN

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4 CRBN

Single Molecule Studies of Eukaryotic Replisomes in Xenopus Egg Extracts

CRL4[super]Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase

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