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Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b

Immunity (Cambridge, Mass.), 2011-08, Vol.35 (2), p.182-193

2011

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Robust performance of a live bacterial therapeutic chassis lacking the colibactin gene cluster

PloS one, 2023-02, Vol.18 (2), p.e0280499-e0280499

2023

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Engineered bacteria producing aryl‐hydrocarbon receptor agonists protect against ethanol‐induced liver disease in mice

Alcohol, clinical & experimental research, 2023-05, Vol.47 (5), p.856-867

2023

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Phase I study of SYNB1891, an engineered E coli Nissle strain expressing STING agonist, with and without atezolizumab in advanced malignancies

Clinical cancer research, 2023-07, Vol.29 (13), p.2435-2444

2023

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M. tuberculosis and M. leprae Translocate from the Phagolysosome to the Cytosol in Myeloid Cells

Cell, 2007-06, Vol.129 (7), p.1287-1298

2007

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Rational Engineering of Escherichia coli Nissle 1917 as Live Biotherapeutic to Degrade Uremic Toxin Precursors

ACS synthetic biology, 2024-04, Vol.13 (4), p.1077-1084

2024

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An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria

Molecular systems biology, 2022-03, Vol.18 (3), p.e10539-n/a

2022

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The pharmacokinetics, pharmacodynamics and tolerability of PUR0200, a novel tiotropium formulation, in chronic obstructive pulmonary disease

British journal of clinical pharmacology, 2018-09, Vol.84 (9), p.2097-2105

2018

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The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers

Cell host & microbe, 2024-03, Vol.32 (3), p.382-395.e10

2024

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Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation

Cell, 2022-08, Vol.185 (16), p.2879-2898.e24

2022

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A phase 1/1b study of PUR1900, an inhaled formulation of itraconazole, in healthy volunteers and asthmatics to study safety, tolerability and pharmacokinetics

British journal of clinical pharmacology, 2020-04, Vol.86 (4), p.723-733

2020

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Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies

Clinical cancer research, 2023-07, Vol.29 (13), p.2435-2444

2023

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Allergic Diseases Caused by Aspergillus Species in Patients with Cystic Fibrosis

Antibiotics (Basel), 2021-03, Vol.10 (4), p.357

2021

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RrgA and RrgB Are Components of a Multisubunit Pilus Encoded by the Streptococcus pneumoniae rlrA Pathogenicity Islet

Infection and Immunity, 2006-04, Vol.74 (4), p.2453-2456

2006

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Particle size and gastrointestinal absorption influence tiotropium pharmacokinetics: a pilot bioequivalence study of PUR0200 and Spiriva HandiHaler

British journal of clinical pharmacology, 2019-03, Vol.85 (3), p.580-589

2019

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Synthetic biology: at the crossroads of genetic engineering and human therapeutics—a Keystone Symposia report

Annals of the New York Academy of Sciences, 2021-12, Vol.1506 (1), p.98-117

2021

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Pulmonary and Regional Deposition of Nebulized and Dry Powder Aerosols in Ferrets

AAPS PharmSciTech, 2019-08, Vol.20 (6), p.242-242, Article 242

2019

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Calcium restores the macrophage response to nontypeable haemophilus influenzae in chronic obstructive pulmonary disease

American journal of respiratory cell and molecular biology, 2015-06, Vol.52 (6), p.728-737

2015

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Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae

Molecular microbiology, 2002-03, Vol.43 (6), p.1471-1491

2002

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Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules

European journal of immunology, 2008-08, Vol.38 (8), p.2351-2359

2008

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Regulation and temporal expression patterns of Vibrio cholerae virulence genes during infection

Cell, 1999-12, Vol.99 (6), p.625-634

1999

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Inhaled calcium salts inhibit tobacco smoke-induced inflammation by modulating expression of chemokines and cytokines

Pulmonary pharmacology & therapeutics, 2018-12, Vol.53, p.86-99

2018

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Transcriptional Regulation in the Streptococcus pneumoniae rlrA Pathogenicity Islet by RlrA

Journal of Bacteriology, 2003-01, Vol.185 (2), p.413-421

2003

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role for the B-cell CD74/macrophage migration inhibitory factor pathway in the immunomodulation of systemic lupus erythematosus by a therapeutic tolerogenic peptide

Immunology, 2011, Vol.132 (1), p.87-95

2011

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From nose to lung: the regulation behind Streptococcus pneumoniae virulence factors

Molecular microbiology, 2003-11, Vol.50 (4), p.1103-1110

2003

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Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b

Robust performance of a live bacterial therapeutic chassis lacking the colibactin gene cluster

Engineered bacteria producing aryl‐hydrocarbon receptor agonists protect against ethanol‐induced liver disease in mice

Phase I study of SYNB1891, an engineered E coli Nissle strain expressing STING agonist, with and without atezolizumab in advanced malignancies

M. tuberculosis and M. leprae Translocate from the Phagolysosome to the Cytosol in Myeloid Cells

Rational Engineering of Escherichia coli Nissle 1917 as Live Biotherapeutic to Degrade Uremic Toxin Precursors

An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria

The pharmacokinetics, pharmacodynamics and tolerability of PUR0200, a novel tiotropium formulation, in chronic obstructive pulmonary disease

The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers

Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation

A phase 1/1b study of PUR1900, an inhaled formulation of itraconazole, in healthy volunteers and asthmatics to study safety, tolerability and pharmacokinetics

Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies

Allergic Diseases Caused by Aspergillus Species in Patients with Cystic Fibrosis

RrgA and RrgB Are Components of a Multisubunit Pilus Encoded by the Streptococcus pneumoniae rlrA Pathogenicity Islet

Particle size and gastrointestinal absorption influence tiotropium pharmacokinetics: a pilot bioequivalence study of PUR0200 and Spiriva HandiHaler

Synthetic biology: at the crossroads of genetic engineering and human therapeutics—a Keystone Symposia report

Pulmonary and Regional Deposition of Nebulized and Dry Powder Aerosols in Ferrets

Calcium restores the macrophage response to nontypeable haemophilus influenzae in chronic obstructive pulmonary disease

Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae

Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules

Regulation and temporal expression patterns of Vibrio cholerae virulence genes during infection

Inhaled calcium salts inhibit tobacco smoke-induced inflammation by modulating expression of chemokines and cytokines

Transcriptional Regulation in the Streptococcus pneumoniae rlrA Pathogenicity Islet by RlrA

role for the B-cell CD74/macrophage migration inhibitory factor pathway in the immunomodulation of systemic lupus erythematosus by a therapeutic tolerogenic peptide

From nose to lung: the regulation behind Streptococcus pneumoniae virulence factors

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