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Applications of machine learning to diagnosis and treatment of neurodegenerative diseases

Nature reviews. Neurology, 2020-08, Vol.16 (8), p.440-456

2020

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Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions

Brain (London, England : 1878), 2014-07, Vol.137 (Pt 7), p.2040-2051

2014

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C9orf72 expansion disrupts ATM-mediated chromosomal break repair

Nature neuroscience, 2017-09, Vol.20 (9), p.1225-1235

2017

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The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

The EMBO journal, 2016-08, Vol.35 (15), p.1656-1676

2016

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Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

EBioMedicine, 2019-02, Vol.40, p.626-635

2019

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RNA Nuclear Export: From Neurological Disorders to Cancer

Advances in experimental medicine and biology, 2017, Vol.1007, p.89-109

2017

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TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export

Nature communications, 2012, Vol.3 (1), p.1006-1006, Article 1006

2012

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Proteinopathies as Hallmarks of Impaired Gene Expression, Proteostasis and Mitochondrial Function in Amyotrophic Lateral Sclerosis

Frontiers in neuroscience, 2021-12, Vol.15, p.783624-783624

2021

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The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

Nature communications, 2023-09, Vol.14 (1), p.5496-5496, Article 5496

2023

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The Use of Plant-Derived Ribosome Inactivating Proteins in Immunotoxin Development: Past, Present and Future Generations

Toxins, 2017-10, Vol.9 (11), p.344

2017

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RAN Translation of C9orf72-Related Dipeptide Repeat Proteins in Zebrafish Recapitulates Hallmarks of Amyotrophic Lateral Sclerosis and Identifies Hypothermia as a Therapeutic Strategy

Annals of neurology, 2024-08

2024

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Therapeutic strategies for C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia

Current opinion in neurology, 2021-10, Vol.34 (5), p.748-755

2021

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Chtop is a component of the dynamic TREX mRNA export complex

The EMBO journal, 2013-02, Vol.32 (3), p.473-486

2013

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Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy

Acta neuropathologica, 2015-07, Vol.130 (1), p.63-75

2015

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Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells

Toxins, 2018-06, Vol.10 (7), p.261

2018

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A Simple Method for Improving Protein Solubility and Long-Term Stability

Journal of the American Chemical Society, 2004-07, Vol.126 (29), p.8933-8939

2004

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Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis

Brain (London, England : 1878), 2019-03, Vol.142 (3), p.586-605

2019

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Ribosome-inactivating proteins: Potent poisons and molecular tools

Virulence, 2013-11, Vol.4 (8), p.774-784

2013

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Competitive and cooperative interactions mediate RNA transfer from herpesvirus saimiri ORF57 to the mammalian export adaptor ALYREF

PLoS pathogens, 2014-02, Vol.10 (2), p.e1003907

2014

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Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease

Aging cell, 2021-01, Vol.20 (1), p.e13281-n/a

2021

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Mechanisms of repeat-associated non-AUG translation in neurological microsatellite expansion disorders

Biochemical Society transactions, 2021-04, Vol.49 (2), p.775-792

2021

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Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

Acta neuropathologica communications, 2018-11, Vol.6 (1), p.125-125, Article 125

2018

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A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations

Frontiers in aging neuroscience, 2023-05, Vol.15, p.1151848

2023

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Structural basis for the recognition of cellular mRNA export factor REF by herpes viral proteins HSV-1 ICP27 and HVS ORF57

PLoS pathogens, 2011-01, Vol.7 (1), p.e1001244

2011

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RNP granules in ALS and neurodegeneration: From multifunctional membraneless organelles to therapeutic opportunities

International review of neurobiology, 2024, Vol.176, p.455

2024

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Applications of machine learning to diagnosis and treatment of neurodegenerative diseases

Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions

C9orf72 expansion disrupts ATM-mediated chromosomal break repair

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

RNA Nuclear Export: From Neurological Disorders to Cancer

TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export

Proteinopathies as Hallmarks of Impaired Gene Expression, Proteostasis and Mitochondrial Function in Amyotrophic Lateral Sclerosis

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

The Use of Plant-Derived Ribosome Inactivating Proteins in Immunotoxin Development: Past, Present and Future Generations

RAN Translation of C9orf72-Related Dipeptide Repeat Proteins in Zebrafish Recapitulates Hallmarks of Amyotrophic Lateral Sclerosis and Identifies Hypothermia as a Therapeutic Strategy

Therapeutic strategies for C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia

Chtop is a component of the dynamic TREX mRNA export complex

Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy

Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells

A Simple Method for Improving Protein Solubility and Long-Term Stability

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis

Ribosome-inactivating proteins: Potent poisons and molecular tools

Competitive and cooperative interactions mediate RNA transfer from herpesvirus saimiri ORF57 to the mammalian export adaptor ALYREF

Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease

Mechanisms of repeat-associated non-AUG translation in neurological microsatellite expansion disorders

Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations

Structural basis for the recognition of cellular mRNA export factor REF by herpes viral proteins HSV-1 ICP27 and HVS ORF57

RNP granules in ALS and neurodegeneration: From multifunctional membraneless organelles to therapeutic opportunities

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