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Dabigatran: an oral novel potent reversible nonpeptide inhibitor of thrombin

Arteriosclerosis, thrombosis, and vascular biology, 2010-10, Vol.30 (10), p.1885-1889

2010

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In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate

Thrombosis and haemostasis, 2007-07, Vol.98 (1), p.155-162

2007

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Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors

Journal of medicinal chemistry, 2002-04, Vol.45 (9), p.1757-1766

2002

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Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats

Thrombosis and haemostasis, 2007-08, Vol.98 (2), p.333-338

2007

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Mechanism of Human Telomerase Inhibition by BIBR1532, a Synthetic, Non-nucleosidic Drug Candidate

The Journal of biological chemistry, 2002-05, Vol.277 (18), p.15566-15572

2002

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Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (14), p.2297-2302

2003

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Structural Basis for Inhibition Promiscuity of Dual Specific Thrombin and Factor Xa Blood Coagulation Inhibitors

Structure (London), 2001-01, Vol.9 (1), p.29-37

2001

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Dabigatran Inhibits Both Clot-Bound and Fluid Phase Thrombin In Vitro: Effects Compared to Heparin and Hirudin

Blood, 2007-11, Vol.110 (11), p.3998-3998

2007

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6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships

Journal of medicinal chemistry, 1993-12, Vol.36 (25), p.4040-4051

1993

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Dabigatran Etexilate : Pharmacology of the New, Oral Direct Thrombin Inhibitor

Nihon Kessen Shiketsu Gakkai shi, 2011, Vol.22 (4), p.143-150

2011

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Heterocyclic thrombin inhibitors. Part 1: design and synthesis of amidino-phenoxy quinoline derivatives

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (14), p.2291-2295

2003

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A highly selective telomerase inhibitor limiting human cancer cell proliferation

The EMBO journal, 2001-12, Vol.20 (24), p.6958-6968

2001

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The discovery of dabigatran etexilate

Frontiers in pharmacology, 2013-01, Vol.4, p.12

2013

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3,5-Dihydro-imidazo[4,5- d]pyridazin-4-ones: A class of potent DPP-4 inhibitors

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3158-3162

2008

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Synthesis of 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one and 3-alkyl-2-bromo-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one and their selective elaboration

Tetrahedron letters, 2008-03, Vol.49 (12), p.1931-1934

2008

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DABIGATRAN ANTICOAGULANT ACTIVITY IS NEUTRALIZED BY AN ANTIBODY SELECTIVE TO DABIGATRAN IN IN VITRO AND IN VIVO MODELS

Journal of the American College of Cardiology, 2011-04, Vol.57 (14), p.E1130-E1130

2011

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Comparison of the Antithrombotic Effectiveness of the Direct Thrombin Inhibitor, Dabigatran Etexilate, and Two Factor Xa Inhibitors in an A-V Shunt Model of Thrombosis in Rabbits

Blood, 2007-11, Vol.110 (11), p.3154-3154

2007

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Effects of Dabigatran, a Direct Thrombin Inhibitor, as Compared to the Direct Factor Xa Inhibitors, Rivaroxaban and Apixaban, on Tissue Factor-Induced Human Platelet Aggregation in Platelet Rich Plasma

Blood, 2007-11, Vol.110 (11), p.1884-1884

2007

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Dabigatran Inhibits Arterial Thrombosis in a Porcine Model of Cyclic Flow Reduction

Blood, 2006-11, Vol.108 (11), p.906-906

2006

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Analogue-based Drug Discovery III

1. Aufl., 2013

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A Review on Telmisartan: A Novel, Long‐Acting Angiotensin II‐Receptor Antagonist

Cardiovascular drug reviews, 2000-06, Vol.18 (2), p.127-154

2000

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New cardiotonic agents — a promising approach for treatment of heart failure

Trends in Pharmacological Sciences, 1988-05, Vol.9 (5), p.166-170

1988

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Bicyclofulvene, IX. Stereoelektronische Effekte bei der Addition an 8-Methylentricyclo[3.2.02,4]octan-Derivate

Chemische Berichte, 1983-01, Vol.116 (1), p.389-403

1983

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Addition von Diphenylketen an Quadricyclan-Derivate

Justus Liebigs Annalen der Chemie, 1978-05, Vol.1978 (2), p.312-319

1978

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The Discovery of Dabigatran Etexilate

Analogue‐Based Drug Discovery III, 2012, p.241-267

2012

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Dabigatran: an oral novel potent reversible nonpeptide inhibitor of thrombin

In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate

Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors

Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats

Mechanism of Human Telomerase Inhibition by BIBR1532, a Synthetic, Non-nucleosidic Drug Candidate

Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents

Structural Basis for Inhibition Promiscuity of Dual Specific Thrombin and Factor Xa Blood Coagulation Inhibitors

Dabigatran Inhibits Both Clot-Bound and Fluid Phase Thrombin In Vitro: Effects Compared to Heparin and Hirudin

6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships

Dabigatran Etexilate : Pharmacology of the New, Oral Direct Thrombin Inhibitor

Heterocyclic thrombin inhibitors. Part 1: design and synthesis of amidino-phenoxy quinoline derivatives

A highly selective telomerase inhibitor limiting human cancer cell proliferation

The discovery of dabigatran etexilate

3,5-Dihydro-imidazo[4,5- d]pyridazin-4-ones: A class of potent DPP-4 inhibitors

Synthesis of 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one and 3-alkyl-2-bromo-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one and their selective elaboration

DABIGATRAN ANTICOAGULANT ACTIVITY IS NEUTRALIZED BY AN ANTIBODY SELECTIVE TO DABIGATRAN IN IN VITRO AND IN VIVO MODELS

Comparison of the Antithrombotic Effectiveness of the Direct Thrombin Inhibitor, Dabigatran Etexilate, and Two Factor Xa Inhibitors in an A-V Shunt Model of Thrombosis in Rabbits

Effects of Dabigatran, a Direct Thrombin Inhibitor, as Compared to the Direct Factor Xa Inhibitors, Rivaroxaban and Apixaban, on Tissue Factor-Induced Human Platelet Aggregation in Platelet Rich Plasma

Dabigatran Inhibits Arterial Thrombosis in a Porcine Model of Cyclic Flow Reduction

Analogue-based Drug Discovery III

A Review on Telmisartan: A Novel, Long‐Acting Angiotensin II‐Receptor Antagonist

New cardiotonic agents — a promising approach for treatment of heart failure

Bicyclofulvene, IX. Stereoelektronische Effekte bei der Addition an 8-Methylentricyclo[3.2.02,4]octan-Derivate

Addition von Diphenylketen an Quadricyclan-Derivate

The Discovery of Dabigatran Etexilate

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