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The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

Pulmonary pharmacology & therapeutics, 2010-08, Vol.23 (4), p.235-256

2010

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Potent Inhibition of Ca2+ Release-activated Ca2+ Channels and T-lymphocyte Activation by the Pyrazole Derivative BTP2

The Journal of biological chemistry, 2004-03, Vol.279 (13), p.12427-12437

2004

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Cytokine-dependent balance of mitogenic effects in primary human lung fibroblasts related to cyclic AMP signaling and phosphodiesterase 4 inhibition

Journal of cellular physiology, 2010-05, Vol.223 (2), p.317-326

2010

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Phosphodiesterase 2 Mediates Redox-Sensitive Endothelial Cell Proliferation and Angiogenesis by Thrombin via Rac1 and NADPH Oxidase 2

Circulation research, 2009-05, Vol.104 (10), p.1169-1177

2009

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In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide

The Journal of pharmacology and experimental therapeutics, 2004-04, Vol.309 (1), p.249

2004

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Effects of roflumilast, a phosphodiesterase-4 inhibitor, on hypoxia- and monocrotaline-induced pulmonary hypertension in rats

The Journal of pharmacology and experimental therapeutics, 2009-07, Vol.330 (1), p.54

2009

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Effects of the soluble guanylyl cyclase activator, YC‐1, on vascular tone, cyclic GMP levels and phosphodiesterase activity

British journal of pharmacology, 1999-05, Vol.127 (1), p.195-203

1999

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Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia

Critical care medicine, , Vol.37 (2), p.584-590

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Pharmacology, clinical efficacy, and tolerability of phosphodiesterase-4 inhibitors: impact of human pharmacokinetics

Handbook of experimental pharmacology, 2011 (204), p.85

2011

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The differential impact of PDE4 subtypes in human lung fibroblasts on cytokine-induced proliferation and myofibroblast conversion

Journal of cellular physiology, 2011-08, Vol.226 (8), p.1970-1980

2011

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Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro

The Journal of pharmacology and experimental therapeutics, 2001-04, Vol.297 (1), p.267

2001

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Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects

British journal of pharmacology, 1996-08, Vol.118 (7), p.1727-1735

1996

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Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: A comparative study

Journal of allergy and clinical immunology, 1997-10, Vol.100 (4), p.527-535

1997

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Inhibition of TGF-β induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase

European journal of pharmacology, 2007-10, Vol.572 (1), p.12-22

2007

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Differential Expression and Function of Phosphodiesterase 4 (PDE4) Subtypes in Human Primary CD4+ T Cells: Predominant Role of PDE4D

The Journal of immunology (1950), 2007-04, Vol.178 (8), p.4820-4831

2007

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Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells

Biochemical pharmacology, 2010-02, Vol.79 (3), p.321-329

2010

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Characterization of the Phosphodiesterase (PDE) Pattern of in Vitro-Generated Human Dendritic Cells (DC) and the Influence of PDE Inhibitors on DC Function

Pulmonary pharmacology & therapeutics, 1999-12, Vol.12 (6), p.377-386

1999

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In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor

The Journal of pharmacology and experimental therapeutics, 2001-04, Vol.297 (1), p.280

2001

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Protection from T cell-mediated murine liver failure by phosphodiesterase inhibitors

The Journal of pharmacology and experimental therapeutics, 1997-01, Vol.280 (1), p.53

1997

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Characterization of inhibitors of phosphodiesterase 1C on a human cellular system

The FEBS journal, 2007-09, Vol.274 (18), p.4812-4824

2007

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Tumor necrosis factor-α–dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability

Blood, 2005-05, Vol.105 (9), p.3569-3576

2005

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The effect of Sildenafil on human platelet secretory function is controlled by a complex interplay between phosphodiesterases 2, 3 and 5

Cellular signalling, 2005-03, Vol.17 (3), p.331-339

2005

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Phosphodiesterase inhibitors: history of pharmacology

Handbook of experimental pharmacology, 2011 (204), p.1

2011

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Celecoxib dilates guinea-pig coronaries and rat aortic rings and amplifies NO/cGMP signaling by PDE5 inhibition

Cardiovascular research, 2007-07, Vol.75 (2), p.390-397

2007

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The New Phosphodiesterase 4 Inhibitor Roflumilast Is Efficacious in Exercise-Induced Asthma and Leads to Suppression of LPS-Stimulated TNF-α Ex Vivo

Journal of clinical pharmacology, 2002-03, Vol.42 (3), p.297-303

2002

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The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

Potent Inhibition of Ca2+ Release-activated Ca2+ Channels and T-lymphocyte Activation by the Pyrazole Derivative BTP2

Cytokine-dependent balance of mitogenic effects in primary human lung fibroblasts related to cyclic AMP signaling and phosphodiesterase 4 inhibition

Phosphodiesterase 2 Mediates Redox-Sensitive Endothelial Cell Proliferation and Angiogenesis by Thrombin via Rac1 and NADPH Oxidase 2

In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide

Effects of roflumilast, a phosphodiesterase-4 inhibitor, on hypoxia- and monocrotaline-induced pulmonary hypertension in rats

Effects of the soluble guanylyl cyclase activator, YC‐1, on vascular tone, cyclic GMP levels and phosphodiesterase activity

Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia

Pharmacology, clinical efficacy, and tolerability of phosphodiesterase-4 inhibitors: impact of human pharmacokinetics

The differential impact of PDE4 subtypes in human lung fibroblasts on cytokine-induced proliferation and myofibroblast conversion

Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro

Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects

Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: A comparative study

Inhibition of TGF-β induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase

Differential Expression and Function of Phosphodiesterase 4 (PDE4) Subtypes in Human Primary CD4+ T Cells: Predominant Role of PDE4D

Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells

Characterization of the Phosphodiesterase (PDE) Pattern of in Vitro-Generated Human Dendritic Cells (DC) and the Influence of PDE Inhibitors on DC Function

In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor

Protection from T cell-mediated murine liver failure by phosphodiesterase inhibitors

Characterization of inhibitors of phosphodiesterase 1C on a human cellular system

Tumor necrosis factor-α–dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability

The effect of Sildenafil on human platelet secretory function is controlled by a complex interplay between phosphodiesterases 2, 3 and 5

Phosphodiesterase inhibitors: history of pharmacology

Celecoxib dilates guinea-pig coronaries and rat aortic rings and amplifies NO/cGMP signaling by PDE5 inhibition

The New Phosphodiesterase 4 Inhibitor Roflumilast Is Efficacious in Exercise-Induced Asthma and Leads to Suppression of LPS-Stimulated TNF-α Ex Vivo

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