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Therapeutic Implications for the Induced Levels of Chk1 in Myc-Expressing Cancer Cells

Clinical cancer research, 2011-11, Vol.17 (22), p.7067-7079

2011

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Discovery of N‑Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo‑1H‑pyrrolo[2,3‑c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

Journal of medicinal chemistry, 2020-05, Vol.63 (10), p.5585-5623

2020

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Discovery of N -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1 H -pyrrolo[2,3- c ]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

Journal of medicinal chemistry, 2020-05, Vol.63 (10), p.5585-5623

2020

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Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors

Journal of medicinal chemistry, 2007-08, Vol.50 (17), p.4162-4176

2007

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Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (8), p.2293-2298

2006

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Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1804-1810

2018

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Methylpyrrole inhibitors of BET bromodomains

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (10), p.2225-2233

2017

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Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

Journal of medicinal chemistry, 2009-11, Vol.52 (21), p.6621-6636

2009

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Palladium(II)-Catalyzed Cyclization of Olefinic Tosylamides

Journal of organic chemistry, 1996-05, Vol.61 (11), p.3584-3585

1996

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Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

Nature (London), 2020-02, Vol.578 (7794), p.306-310

2020

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Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[ b, e][1,4]diazepin-11-ones as potent Chk1 inhibitors

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (7), p.2311-2315

2008

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Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (1), p.153-158

2005

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Abstract 931: Discovery of ABBV-744, a first-in-class highly BDII-selective BET bromodomain inhibitor

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.931-931

2018

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Methylpyrrole inhibitors of BET bromodomains

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (10)

2017

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Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.4001-4005

2003

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Discovery of 3 H -Benzo[4,5]thieno[3,2- d ]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

Journal of medicinal chemistry, 2009-11, Vol.52 (21), p.6621-6636

2009

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Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo-[b,e][1,4]diazepin-11-ones as potent Chkl inhibitors

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (7), p.2311-2315

2008

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Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chkl kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (8), p.2293-2298

2006

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Pyridone-Containing Farnesyltransferase Inhibitors: Synthesis and Biological Evaluation

ChemInform, 2004-03, Vol.35 (9), p.no-no

2004

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Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies

Cancer research (Chicago, Ill.), 2017-06, Vol.77 (11), p.2976-2989

2017

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Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2180-2194

2015

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Abstract 4695: Functional group elaboration of a low molecular weight fragment to yield the novel BET family bromodomain inhibitor ABBV-075

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4695-4695

2016

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Therapeutic Implications for the Induced Levels of Chk1 in Myc-Expressing Cancer Cells

Discovery of N‑Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo‑1H‑pyrrolo[2,3‑c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

Discovery of N -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1 H -pyrrolo[2,3- c ]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

Discovery of N‑(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro‑1H‑pyrrolo[2,3‑c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor

Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors

Methylpyrrole inhibitors of BET bromodomains

Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

Palladium(II)-Catalyzed Cyclization of Olefinic Tosylamides

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[ b, e][1,4]diazepin-11-ones as potent Chk1 inhibitors

Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase

Abstract 931: Discovery of ABBV-744, a first-in-class highly BDII-selective BET bromodomain inhibitor

Methylpyrrole inhibitors of BET bromodomains

Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation

Discovery of 3 H -Benzo[4,5]thieno[3,2- d ]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo-[b,e][1,4]diazepin-11-ones as potent Chkl inhibitors

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chkl kinase inhibitors

Pyridone-Containing Farnesyltransferase Inhibitors: Synthesis and Biological Evaluation

Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies

Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity

Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity

Abstract 4695: Functional group elaboration of a low molecular weight fragment to yield the novel BET family bromodomain inhibitor ABBV-075

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